Flexible Substrate-Based Devices for Point-of-Care Diagnostics

Wang, Shuqi; Chinnasamy, Thiruppathiraja; Lifson, Mark A.; İnci, Fatih; Demirci, Utkan

doi:10.1016/j.tibtech.2016.05.009

Cited by 192 publications

(106 citation statements)

References 76 publications

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“…Due to the invasiveness, these techniques are not suitable for continuous monitoring. Moreover, many diseases may not have a morphological analog of the "gold standard," which necessitates the permanent expansion of functional and point-of-care diagnostics in clinical practice [214,215]. The search for safe, reliable, and inexpensive methods has resulted, for example, in the development of a large number of biomarkers for noninvasive assessment of liver fibrosis representing both simple, directly measurable parameters and their derivatives (indices or ratios), which increase the sensitivity and/or specificity of assessment (diagnosis): the ratio of the level of AST to the level of ALT-the so-called De Ritis ratio; the ratio of AST to the number of platelets; PGA index-the ratio of prothrombin time and the level of GGT and apolipoprotein A1 (the PGA index was later modified due to α-2-macroglobulin and became known as the PGAA index); and the…”

Section: New Methodological Techniques For Identifying Newmentioning

confidence: 99%

Markers and Biomarkers of Endothelium: When Something Is Rotten in the State

Гончаров

Nadeev

Jenkins

et al. 2017

Oxidative Medicine and Cellular Longevity

159

115

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Endothelium is a community of endothelial cells (ECs), which line the blood and lymphatic vessels, thus forming an interface between the tissues and the blood or lympha. This strategic position of endothelium infers its indispensable functional role in controlling vasoregulation, haemostasis, and inflammation. The state of endothelium is simultaneously the cause and effect of many diseases, and this is coupled with modifications of endothelial phenotype represented by markers and with biochemical profile of blood represented by biomarkers. In this paper, we briefly review data on the functional role of endothelium, give definitions of endothelial markers and biomarkers, touch on the methodological approaches for revealing biomarkers, present an implicit role of endothelium in some toxicological mechanistic studies, and survey the role of reactive oxygen species (ROS) in modulation of endothelial status.

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Section: New Methodological Techniques For Identifying Newmentioning

confidence: 99%

Markers and Biomarkers of Endothelium: When Something Is Rotten in the State

Гончаров

Nadeev

Jenkins

et al. 2017

Oxidative Medicine and Cellular Longevity

159

115

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“…It is possible to obtain faster transfers of solutions and better color yield with thinner substrates. The use of flexible transparent materials along with colorimetric detection process can significantly enhance the sensitivity for POC assays [82]. …”

Section: Sensing Technologies Used In μPadsmentioning

confidence: 99%

Paper-based analytical devices for clinical diagnosis: recent advances in the fabrication techniques and sensing mechanisms

Sher

Zhuang²,

Demirci³

et al. 2017

Expert Review of Molecular Diagnostics

Self Cite

217

157

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Introduction There is a significant interest in developing inexpensive portable biosensing platforms for various applications including disease diagnostics, environmental monitoring, food safety, and water testing at the point-of-care (POC) settings. Current diagnostic assays available in the developed world require sophisticated laboratory infrastructure and expensive reagents. Hence, they are not suitable for resource-constrained settings with limited financial resources, basic health infrastructure, and few trained technicians. Cellulose and flexible transparency paper-based analytical devices have demonstrated enormous potential for developing robust, inexpensive and portable devices for disease diagnostics. These devices offer promising solutions to disease management in resource-constrained settings where the vast majority of the population cannot afford expensive and highly sophisticated treatment options. Areas covered In this review, the authors describe currently developed cellulose and flexible transparency paper-based microfluidic devices, device fabrication techniques, and sensing technologies that are integrated with these devices. The authors also discuss the limitations and challenges associated with these devices and their potential in clinical settings. Expert commentary In recent years, cellulose and flexible transparency paper-based microfluidic devices have demonstrated the potential to become future healthcare options despite a few limitations such as low sensitivity and reproducibility.

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“…South Africa accounts for 18% of global HIV infections, with approximately 6.7 million people infected [9]. Significant progress has been made in developing and the deployment of affordable HIV POC diagnostic tests for resource-limited settings [7,10]. However, there are still many unmet diagnostic needs for some of the well-established communicable diseases, such as tuberculosis [7].…”

Section: Introductionmentioning

confidence: 99%

Implementation of Point-of-Care Diagnostics in Rural Primary Healthcare Clinics in South Africa: Perspectives of Key Stakeholders

et al. 2017

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Introduction: Key stakeholders’ involvement is crucial to the sustainability of quality point-of-care (POC) diagnostics services in low-and-middle income countries. The aim of this study was to explore key stakeholder perceptions on the implementation of POC diagnostics in rural primary healthcare (PHC) clinics in South Africa. Method: We conducted a qualitative study encompassing in-depth interviews with multiple key stakeholders of POC diagnostic services for rural and resource-limited PHC clinics. Interviews were digitally recorded and transcribed verbatim prior to thematic content analysis. Thematic content analysis was conducted using themes guided by the World Health Organisation (WHO) quality-ASSURED (Affordable, Sensitive, Specific, User friendly, Rapid and to enable treatment at first visit and Robust, Equipment free and Delivered to those who need it) criteria for POC diagnostic services in resource-limited settings. Results: 11 key stakeholders participated in the study. All stakeholders perceived the main advantage of POC diagnostics as enabling access to healthcare for rural patients. Stakeholders perceived the current POC diagnostic services to have an ability to meet patients’ needs, but recommended further improvement of the following areas: research on cost-effectiveness; improved quality management systems; development of affordable POC diagnostic and clinic-based monitoring and evaluation. Conclusions: Key stakeholders of POC diagnostics in rural PHC clinics in South Africa highlighted the need to assess affordability and ensure quality assurance of current services before adopting new POC diagnostics and scaling up current POC diagnostics.

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Flexible Substrate-Based Devices for Point-of-Care Diagnostics

Cited by 192 publications

References 76 publications

Markers and Biomarkers of Endothelium: When Something Is Rotten in the State

Markers and Biomarkers of Endothelium: When Something Is Rotten in the State

Paper-based analytical devices for clinical diagnosis: recent advances in the fabrication techniques and sensing mechanisms

Implementation of Point-of-Care Diagnostics in Rural Primary Healthcare Clinics in South Africa: Perspectives of Key Stakeholders

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