Flexible, stretchable, and single-molecule-sensitive SERS-active sensor for wearable biosensing applications

Chowdhury, Manjur A.; Tasnim, Nishat; Hossain, Mainul; Habib, Ahsan

doi:10.1039/d3ra03050d

Cited by 5 publications

(6 citation statements)

References 54 publications

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“…Flexible wearable sensors are widely used in many fields, such as medicine, 44 sports, 45 and entertainment. 46 These sensors must be able to effectively adhere to skin or clothing to avoid the loss of sensing signals.…”

Section: Resultsmentioning

confidence: 99%

A “Mesh Scaffold” that regulates the mechanical properties and restricts the phase transition-induced volume change of the PNIPAM-based hydrogel for wearable sensors

Zhang,

Ding,

et al. 2024

Mater. Horiz.

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Section: Resultsmentioning

confidence: 99%

A “Mesh Scaffold” that regulates the mechanical properties and restricts the phase transition-induced volume change of the PNIPAM-based hydrogel for wearable sensors

Zhang,

Ding,

et al. 2024

Mater. Horiz.

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“…This phenomenon begets a corresponding modulation in the SERS intensity, engendered through the localized plasmon resonance condition [44][45][46][47]. Indeed, some wearable SERS devices, implementing a flexible film, manifest alterations in SERS intensity contingent upon the imposition of bending, stretching, and applied pressure [18,23,24], diverging from other wearable SERS devices utilizing flexible films [20,24,25]. Briefly, these wearable SERS devices incorporated into a film through the techniques of decoration, synthesis, and deposition are convenient to manufacture and possess scalability, but they exhibit limitations in terms of flexibility and stretchability.…”

Section: Film Substratesmentioning

confidence: 99%

“…In a separate instance, gold was thermally deposited onto a periodically arranged monolayer of polystyrene, following which the plasmonic nanostructures were skillfully transferred onto a contact lens [22]. In a different way to the conventional technique of metal deposition onto nanostructures, heart-shaped gold nanodimers were intricately forged upon polydimethylsiloxane film, achieved by milling and selectively peeling the deposited gold film [23]. Finally, we shall deliberate upon the advantages and drawbacks associated with wearable SERS devices utilizing a film.…”

Section: Film Substratesmentioning

confidence: 99%

“…Conversely, wearable SERS devices employing a flexible film hold the potential to furnish physiological insights such as step count, heart rate, and blood pressure. Notably, the SERS intensity, derived from some wearable SERS devices incorporating a flexible film, responded to flexion, extension, and pressure-induced alterations attributable to the fluctuations in electromagnetic fields within the devices [18,23,24]. Such wearable SERS devices, engineered for physiological data collection, may concurrently provide sweat pH data, given that the pH is derived not from the SERS intensities but from the peak intensity ratios [25,28,33,35].…”

Section: Detection Of Other Parametersmentioning

confidence: 99%

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An emerging tool in healthcare: wearable surface-enhanced Raman Spectroscopy

Kitahama,

Egawa,

Dwivedi

et al. 2024

J. Phys. Photonics

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This perspective explores the progressive domain of wearable surface-enhanced Raman spectroscopy (SERS), underscoring its potential to revolutionize healthcare. As an advanced variation of traditional Raman spectroscopy, SERS offers heightened sensitivity in detecting molecular vibrations. Applied in wearable technology, it provides a mechanism for continuous, non-invasive, real-time monitoring of chemical and biomolecular processes in the human body through biofluids such as sweat and tears. This underscores its immense potential in enabling early disease detection and facilitating personalized medicine. However, the adoption of wearable SERS is not without challenges, which include device miniaturization, reliable biofluid sampling, user comfort, biocompatibility, and data interpretation. Nevertheless, this perspective emphasizes that the fast-paced advancements in nanotechnology and data sciences render these challenges surmountable. In summary, the perspective presents wearable SERS as a promising innovation in healthcare's future landscape. It has the potential to enhance individual health outcomes significantly and lower healthcare costs by promoting a preventive health management approach.

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“…It shows the advantages of the prepared flexible SERS substrate for high sensitivity detection. In addition, the flexible SERS substrates prepared in these reports [50][51][52][53], for example, rely on photolithography and have excellent application properties. However, it is difficult and costly to realize large-area preparation by photolithography.…”

Section: Sers Sers Raman Ramanmentioning

confidence: 99%

High-performance, large-area flexible SERS substrates prepared by reactive ion etching for molecular detection

Yang,

Zeng,

Zhou

et al. 2024

Nanotechnology

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In the realm of molecular detection, the Surface-Enhanced Raman Scattering (SERS) technique has garnered increasing attention due to its rapid detection, high sensitivity, and non-destructive characteristics. However, conventional rigid SERS substrates are either costly to fabricate and challenging to prepare over a large area, or they exhibit poor uniformity and repeatability, making them unsuitable for inspecting curved object surfaces. In this work, we present a flexible SERS substrate with high sensitivity as well as good uniformity and repeatability. First, the flexible polydimethylsiloxane (PDMS) substrate is manually formulated and cured. SiO2/Ag layer on the substrate can be obtained in a single process by using ion beam sputtering. Then, reactive ion etching (RIE) is used to etch the upper SiO2 layer of the film, which directly leads to the desired densely packed nanostructure. Finally, a layer of precious metal is deposited on the densely packed nanostructure by thermal evaporation. In our proposed system, the densely packed nanostructure obtained by etching the SiO2 layer directly determines the SERS ability of the substrate. The bottom layer of silver mirror can reflect the penetrative incident light, the spacer layer of SiO2 and the top layer of silver thin film can further localize the light in the system, which can realize the excellent absorption of Raman laser light, thus enhancing SERS ability. In the tests, the prepared substrates show excellent SERS performance in detecting crystalline violet with a detection limit of 10-11 M. The development of this SERS substrate is anticipated to offer a highly effective and convenient method for molecular substance detection.

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Flexible, stretchable, and single-molecule-sensitive SERS-active sensor for wearable biosensing applications

Abstract: Our novel wearable sensor offers unprecedented sensitivity (enhancement factor ∼1011) for remote patient monitoring. It holds great potential for advancing personalized medicine and improving patient care.

Cited by 5 publications

References 54 publications

A “Mesh Scaffold” that regulates the mechanical properties and restricts the phase transition-induced volume change of the PNIPAM-based hydrogel for wearable sensors

A “Mesh Scaffold” that regulates the mechanical properties and restricts the phase transition-induced volume change of the PNIPAM-based hydrogel for wearable sensors

An emerging tool in healthcare: wearable surface-enhanced Raman Spectroscopy

High-performance, large-area flexible SERS substrates prepared by reactive ion etching for molecular detection

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