FNC-RED
exhibits innate immune receptor Toll-like receptor 4 (TLR4)/myeloid
differentiation factor-2 (MD2) stimulatory activity. We have developed
a divergent synthetic route to FNC-RED derivatives containing various
alkyl side chains. Key features of the synthetic study include stepwise
palladium catalyzed cross-coupling reactions and the construction
of an all syn-cyclopentanetetrol moiety.