Flexible ligated ruthenium(II) self-assemblies sensitizes glioma tumor initiating cells <i>in vitro</i>

Elumalai, Palani; Kaushik, Neha; Kim, Dong Hwan; Kim, Hyunuk; Lee, Su Jae; Choi, Eun Ha; Chi, Ki‐Whan; Kaushik, Nagendra Kumar

doi:10.18632/oncotarget.19028

Cited by 5 publications

(4 citation statements)

References 57 publications

(51 reference statements)

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“…Different proteins interacting with such metalla-assemblies have been identified. Interestingly, these studies have shown that metalla-assemblies of different shapes, sizes, structures and numbers of charges are able to interact with proteins, confirming that interaction with biomolecules is a common feature of arene ruthenium metalla-assemblies (Dubey et al, 2015; Elumalai et al, 2016, 2017).…”

Section: Protein Interactionsmentioning

confidence: 80%

The Role of the Second Coordination Sphere in the Biological Activity of Arene Ruthenium Metalla-Assemblies

Therrien

2018

Front. Chem.

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For nearly 15 years, the biological and biomedical applications of arene ruthenium metalla-assemblies have flourished. Today, the synthetic strategies to generate arene ruthenium assemblies are well-established, and these compounds offer tremendous possibilities in terms of structural diversities and chemical properties. However, the second coordination sphere is often poorly considered, if not ignored, when designing such arene ruthenium metalla-assemblies. These weak interactions (hydrogen bonding, hydrophobic, ionic, electrostatic, van der Waals, π-π stacking) that take place in the solid state or in solution are generally key interactions for the foreseen applications. Therefore, in this review, we want to emphasize this important property of arene ruthenium metalla-assemblies by showing examples dealing with second coordination sphere interactions and how this can be better integrated in the design of these versatile supramolecular metal-based entities.

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Section: Protein Interactionsmentioning

confidence: 80%

The Role of the Second Coordination Sphere in the Biological Activity of Arene Ruthenium Metalla-Assemblies

Therrien

2018

Front. Chem.

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“…Previously, Elumalai et al [ 30 ] reported a Ru(II) metallacycle that can eliminate glioma CSCs. The Ru(II) triazine complex has been reported to have the capacity to eradicate colorectal and breast CSCs [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…In this work, we report for the first time that two Ru(II) complexes, 1 and 2, suppress liver CSCs by targeting NF-κB and Akt/mTOR signaling. Previously, Elumalai et al [30] reported a Ru(II) metallacycle that can eliminate glioma CSCs. The Ru(II) triazine complex has been reported to have the capacity to eradicate colorectal and breast CSCs [31].…”

Section: Discussionmentioning

confidence: 99%

Ru(II)-based complexes containing 2-thiouracil derivatives suppress liver cancer stem cells by targeting NF-κB and Akt/mTOR signaling

Bomfim,

Neves,

Coelho

et al. 2024

Cell Death Discov.

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Cancer stem cells (CSCs) are defined as a rare population of cancer cells related to tumor initiation and maintenance. These cells are primarily responsible for tumor growth, invasion, metastasis, recurrence, and resistance to chemotherapy. In this paper, we demonstrated the ability of Ru(II)-based complexes containing 2-thiouracil derivatives with the chemical formulas trans-[Ru(2TU)(PPh3)2(bipy)]PF6 (1) and trans-[Ru(6m2TU)(PPh3)2(bipy)]PF6 (2) (where 2TU = 2-thiouracil and 6m2TU = 6-methyl-2-thiouracil) to suppress liver CSCs by targeting NF-κB and Akt/mTOR signaling. Complexes 1 and 2 displayed potent cytotoxic effects on cancer cell lines and suppressed liver CSCs from HepG2 cells. Increased phosphatidylserine exposure, loss of mitochondrial transmembrane potential, increased PARP (Asp214) cleavage, DNA fragmentation, chromatin condensation and cytoplasmic shrinkage were detected in HepG2 cells treated with these complexes. Mechanistically, complexes 1 and 2 target NF-κB and Akt/mTOR signaling in HepG2 cells. Cell motility inhibition was also detected in HepG2 cells treated with these complexes. Complexes 1 and 2 also inhibited tumor progression in mice with HepG2 cell xenografts and exhibited tolerable systemic toxicity. Taken together, these results indicate that these complexes are new anti-HCC drug candidates that can suppress liver CSCs.

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“…In addition to the works mentioned above, there are other research studies on Ru 2+ ‐coordinated metallabowls, [ 141 ] metallacycles, [ 142 ] and metallogel. [ 80 ] Overall, because of the intrinsic anticancer capability of Ru 2+ , Ru 2+ ‐coordinated intelligent nanomedicine will attract more attention for the development of new cancer theranostic agents in the near future.…”

Section: Metal‐coordinated Supramolecular Self‐assemblies For Cancer ...mentioning

confidence: 99%

Metal‐Coordinated Supramolecular Self‐Assemblies for Cancer Theranostics

Wang

Jin

et al. 2021

Advanced Science

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Metal‐coordinated supramolecular nanoassemblies have recently attracted extensive attention as materials for cancer theranostics. Owing to their unique physicochemical properties, metal‐coordinated supramolecular self‐assemblies can bridge the boundary between traditional inorganic and organic materials. By tailoring the structural components of the metal ions and binding ligands, numerous multifunctional theranostic nanomedicines can be constructed. Metal‐coordinated supramolecular nanoassemblies can modulate the tumor microenvironment (TME), thus facilitating the development of TME‐responsive nanomedicines. More importantly, TME‐responsive organic–inorganic hybrid nanomaterials can be constructed in vivo by exploiting the metal‐coordinated self‐assembly of a variety of functional ligands, which is a promising strategy for enhancing the tumor accumulation of theranostic molecules. In this review, recent advancements in the design and fabrication of metal‐coordinated supramolecular nanomedicines for cancer theranostics are highlighted. These supramolecular compounds are classified according to the order in which the coordinated metal ions appear in the periodic table. Furthermore, the prospects and challenges of metal‐coordinated supramolecular self‐assemblies for both technical advances and clinical translation are discussed. In particular, the superiority of TME‐responsive nanomedicines for in vivo coordinated self‐assembly is elaborated, with an emphasis on strategies that enhance the accumulation of functional components in tumors for an ideal theranostic outcome.

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Flexible ligated ruthenium(II) self-assemblies sensitizes glioma tumor initiating cells in vitro

Cited by 5 publications

References 57 publications

The Role of the Second Coordination Sphere in the Biological Activity of Arene Ruthenium Metalla-Assemblies

The Role of the Second Coordination Sphere in the Biological Activity of Arene Ruthenium Metalla-Assemblies

Ru(II)-based complexes containing 2-thiouracil derivatives suppress liver cancer stem cells by targeting NF-κB and Akt/mTOR signaling

Metal‐Coordinated Supramolecular Self‐Assemblies for Cancer Theranostics

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