Flexible integrated sensing platform for monitoring wound temperature and predicting infection

Zhang, Yuheng; Lin, Bin; Huang, Rong; Lin, Zhixiao; Li, Yongqian; Li, Jinqing; Li, Xueyong

doi:10.1111/1751-7915.13821

“…Based on the data from the ultraviolet–visible spectrophotometry (Fig. S5 ), it was found that fibrinogen remained conformationally stable up to 42 °C, which is the maximum temperature of the chronic wound 47 – 49 . Since the first melting temperature (T m ) of the protein begins from about 59 °C, it is expected that the protein maintains its conformational stability when placed in the wound site.…”

Section: Resultsmentioning

confidence: 99%

Designing a new alginate-fibrinogen biomaterial composite hydrogel for wound healing

Soleimanpour

¹

,

Mirhaji

²

,

Jafari

³

et al. 2022

Sci Rep

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Wound healing is a complex process and rapid healing necessitates a proper micro-environment. Therefore, design and fabrication of an efficacious wound dressing is an impressive innovation in the field of wound healing. The fabricated wound dressing in this scenario was designed using a combination of the appropriate coagulating and anti-bacterial materials like fibrinogen (as coagulating agent), nisin (as anti-bacterial agent), ethylenediaminetetraacetic acid (as anti-bacterial agent), and alginate (as wound healing agent). Biophysical characterization showed that the interaction of fibrinogen and alginate was associated with minor changes in the secondary structure of the protein. Conformational studies showed that the protein was structurally stable at 42 °C, is the maximum temperature of the infected wound. The properties of the hydrogel such as swelling, mechanical resistance, nisin release, antibacterial activity, cytotoxicity, gel porosity, and blood coagulation were assessed. The results showed a slow release for the nisin during 48 h. Antibacterial studies showed an inhibitory effect on the growth of Gram-negative and Gram-positive bacteria. The hydrogel was also capable to absorb a considerable amount of water and provide oxygenation as well as incorporation of the drug into its structure due to its sufficient porosity. Scanning electron microscopy showed pore sizes of about 14–198 µm in the hydrogel. Cell viability studies indicated high biocompatibility of the hydrogel. Blood coagulation test also confirmed the effectiveness of the synthesized hydrogel in accelerating the process of blood clot formation. In vivo studies showed higher rates of wound healing, re-epithelialization, and collagen deposition. According to the findings from in vitro as well as in vivo studies, the designed hydrogel can be considered as a novel attractive wound dressing after further prerequisite assessments.

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“…For instance, Zhang et al. [78] showed that wounds with P. aeruginosa and K. pneumoniae were about 37.5–38 °C, while wounds with S. aureus were 38.5 °C.…”

Section: Wound Biofilm Detectionmentioning

confidence: 99%

Advances in the Sensing and Treatment of Wound Biofilms

Darvishi

¹

,

Tavakoli

²

,

Kharaziha

³

et al. 2022

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Wound biofilms represent a particularly challenging problem in modern medicine. They are increasingly antibiotic resistant and can prevent the healing of chronic wounds. However, current treatment and diagnostic options are hampered by the complexity of the biofilm environment. In this review, we present new chemical avenues in biofilm sensors and new materials to treat wound biofilms, offering promise for better detection, chemical specificity, and biocompatibility. We briefly discuss existing methods for biofilm detection and focus on novel, sensor‐based approaches that show promise for early, accurate detection of biofilm formation on wound sites and that can be translated to point‐of‐care settings. We then discuss technologies inspired by new materials for efficient biofilm eradication. We focus on ultrasound‐induced microbubbles and nanomaterials that can both penetrate the biofilm and simultaneously carry active antimicrobials and discuss the benefits of those approaches in comparison to conventional methods.

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“…[77] Furthermore,h igher local wound temperatures were associated with ag reater risk for Gram-positive infection. Fori nstance,Z hang et al [78] showed that wounds with P. aeruginosa and K. pneumoniae were about 37.5-38 8 8C, while wounds with S. aureus were 38.5 8 8C.…”

Section: Pyocyanina Nd Uric Acidmentioning

confidence: 99%

Advances in the Sensing and Treatment of Wound Biofilms

Darvishi

¹

,

Tavakoli

²

,

Kharaziha

³

et al. 2022

View full text Add to dashboard Cite

Wound biofilms represent a particularly challenging problem in modern medicine. They are increasingly antibiotic resistant and can prevent the healing of chronic wounds. However, current treatment and diagnostic options are hampered by the complexity of the biofilm environment. In this review, we present new chemical avenues in biofilm sensors and new materials to treat wound biofilms, offering promise for better detection, chemical specificity, and biocompatibility. We briefly discuss existing methods for biofilm detection and focus on novel, sensor‐based approaches that show promise for early, accurate detection of biofilm formation on wound sites and that can be translated to point‐of‐care settings. We then discuss technologies inspired by new materials for efficient biofilm eradication. We focus on ultrasound‐induced microbubbles and nanomaterials that can both penetrate the biofilm and simultaneously carry active antimicrobials and discuss the benefits of those approaches in comparison to conventional methods.

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Flexible integrated sensing platform for monitoring wound temperature and predicting infection

Cited by 25 publications

References 36 publications

Designing a new alginate-fibrinogen biomaterial composite hydrogel for wound healing

Designing a new alginate-fibrinogen biomaterial composite hydrogel for wound healing

Advances in the Sensing and Treatment of Wound Biofilms

Advances in the Sensing and Treatment of Wound Biofilms

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