Flexible Electronics toward Wearable Sensing

Gao, Wei; Ota, Hiroki; Kiriya, Daisuke; Takei, Kuniharu; Javey, Ali

doi:10.1021/acs.accounts.8b00500

Cited by 849 publications

(544 citation statements)

References 50 publications

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“…Liquid metals such as gallium (Ga) and its alloys have attracted great attention in the construction of soft and stretchable electronic devices due to their fluidity and high conductivity . Confining the liquid metals in soft microchannels is one of the most common approaches for building soft electronics .…”

Section: Applicationsmentioning

confidence: 99%

Inner Surface Design of Functional Microchannels for Microscale Flow Control

Wang

Yang

et al. 2019

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Fluidic flow behaviors in microfluidics are dominated by the interfaces created between the fluids and the inner surface walls of microchannels. Microchannel inner surface designs, including the surface chemical modification, and the construction of micro‐/nanostructures, are good examples of manipulating those interfaces between liquids and surfaces through tuning the chemical and physical properties of the inner walls of the microchannel. Therefore, the microchannel inner surface design plays critical roles in regulating microflows to enhance the capabilities of microfluidic systems for various applications. Most recently, the rapid progresses in micro‐/nanofabrication technologies and fundamental materials have also made it possible to integrate increasingly complex chemical and physical surface modification strategies with the preparation of microchannels in microfluidics. Besides, a wave of researches focusing on the ideas of using liquids as dynamic surface materials is identified, and the unique characteristics endowed with liquid–liquid interfaces have revealed that the interesting phenomena can extend the scope of interfacial interactions determining microflow behaviors. This review extensively discusses the microchannel inner surface designs for microflow control, especially evaluates them from the perspectives of the interfaces resulting from the inner surface designs. In addition, prospective opportunities for the development of surface designs of microchannels, and their applications are provided with the potential to attract scientific interest in areas related to the rapid development and applications of various microchannel systems.

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Section: Applicationsmentioning

confidence: 99%

Inner Surface Design of Functional Microchannels for Microscale Flow Control

Wang

Yang

et al. 2019

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“…With the emergence of flexible electronics, which possess unique properties to enable a natural interaction between electronics and the human body, a wearable healthcare device that integrates multiple sensors and actuators into flexible substrates to achieve conformal contact with skin has provided new ideas for health monitoring, disease diagnosis, and on‐demand treatment, because such a device can collect meaningful physiological data from the human body and diagnose the status in time for dynamic intervention . To date, researchers have developed many forms of wearable devices to monitor body temperature, heart rate, blood pressure, blood oxygen level, and sweat markers to evaluate human health.…”

Section: Introductionmentioning

confidence: 99%

Smart Flexible Electronics‐Integrated Wound Dressing for Real‐Time Monitoring and On‐Demand Treatment of Infected Wounds

et al. 2020

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As the most frequent wound complication, infection has become a major clinical challenge in wound management. To overcome the “Black Box” status of the wound‐healing process, next‐generation wound dressings with the abilities of real‐time monitoring, diagnosis during early stages, and on‐demand therapy has attracted considerable attention. Here, by combining the emerging development of bioelectronics, a smart flexible electronics‐integrated wound dressing with a double‐layer structure, the upper layer of which is polydimethylsiloxane‐encapsulated flexible electronics integrated with a temperature sensor and ultraviolet (UV) light‐emitting diodes, and the lower layer of which is a UV‐responsive antibacterial hydrogel, is designed. This dressing is expected to provide early infection diagnosis via real‐time wound‐temperature monitoring by the integrated sensor and on‐demand infection treatment by the release of antibiotics from the hydrogel by in situ UV irradiation. The integrated system possesses good flexibility, excellent compatibility, and high monitoring sensitivity and durability. Animal experiment results demonstrate that the integrated system is capable of monitoring wound status in real time, detecting bacterial infection and providing effective treatment on the basis of need. This proof‐of‐concept research holds great promise in developing new strategies to significantly improve wound management and other pathological diagnoses and treatments.

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“…However, a review emphasizing on both wearable devices and microfluidics is still lacking. For instance, Gao et al focused on summarizing flexible electronics toward microfluidics‐based wearable physical and chemical sensing. Wang et al discussed advances of the wearable biosensors for healthcare monitoring, and microfluidic sensor is only one example among many.…”

Section: Introductionmentioning

confidence: 99%

Application of Microfluidics in Wearable Devices

et al. 2019

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Wearable devices integrated with various electronic modules, biological sensors, and chemical sensors have drawn large public attention. Due to their inherent advantages of superior stretchability, elaborate microstructure, high integration of multiple functions, and low cost, microfluidics are an excellent candidate and have already been widely used in wearable devices. Well‐designed microfluidic devices can realize excellent multiple functions in wearable devices, including sample collecting, handling and storage, sample analysis, signal converting and amplification, mechanic sensing, and power supplying. Moreover, the microfluidic wearable devices with further integration of wireless modules have exhibited potential applications in healthcare monitoring, clinical assessment, and human and intelligent device interaction. This review focuses on the latest advances on multifunctional wearable devices based on microfluidics, primarily including general functions and designs of microfluidic wearable devices, and their specific applications in physiological signal monitoring, clinical diagnosis and therapeutics, and healthcare.

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Flexible Electronics toward Wearable Sensing

Cited by 849 publications

References 50 publications

Inner Surface Design of Functional Microchannels for Microscale Flow Control

Inner Surface Design of Functional Microchannels for Microscale Flow Control

Smart Flexible Electronics‐Integrated Wound Dressing for Real‐Time Monitoring and On‐Demand Treatment of Infected Wounds

Application of Microfluidics in Wearable Devices

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