Flexible, dense and porous chitosan and alginate membranes containing the standardized extract of Arrabidaea chica Verlot for the treatment of skin lesions

Pires, Ana Luíza Resende; Westin, Cecília Buzatto; Hernández‐Montelongo, Jacobo; Sousa, Ilza Maria de Oliveira; Foglio, Mary Ann; Moraes, Ângela Maria

doi:10.1016/j.msec.2020.110869

Cited by 11 publications

(13 citation statements)

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“…Although the nanocomposite represented lower elongation compared to the pure sample, it could still be qualified as a superior elastic sheet. The present sample with a thickness of 1 mm exhibited improved mechanical properties compared to the previous flexible antibacterial products, that is, products in References[10,11,27,31].…”

Section: Resultsmentioning

confidence: 85%

“…To improve the flexibility and tensile strength, some researchers have employed the incorporation of chitosan and liquid silicone rubber (SR) as an alternative. In this case, the chitosan/SR blend not only shows good antibacterial activity but it also represents improved mechanical properties 10,11 . For instance, Angela et al 10 reported a significant increase in the flexibility and tensile strength of the antibacterial wound dressings based on chitosan‐alginate after incorporating SR.…”

Section: Introductionmentioning

confidence: 99%

“…Given the even distribution of SR throughout the structure of the chitosan, the crosslinking of the rubber chains at different points improves the tensile strength of the blend 10 . Besides, the siloxane chains in SR can adopt various configurations which decrease the rigidity of the structure and improve the overall flexibility of the blend 11 . In addition to chitosan, metallic nanoparticles, especially Ag and Cu nanoparticles, exhibit promising bactericidal activities against both gram‐positive and gram‐negative bacteria 12,13 .…”

Section: Introductionmentioning

confidence: 99%

“…In this case, the chitosan/SR blend not only shows good antibacterial activity but it also represents improved mechanical properties. 10,11 For instance, Angela et al 10 reported a significant increase in the flexibility and tensile strength of the antibacterial wound dressings based on chitosan-alginate after incorporating SR. Given the even distribution of SR throughout the structure of the chitosan, the crosslinking of the rubber chains at different points improves the tensile strength of the blend.…”

Section: Introductionmentioning

confidence: 99%

“…10 Besides, the siloxane chains in SR can adopt various configurations which decrease the rigidity of the structure and improve the overall flexibility of the blend. 11 In addition to chitosan, metallic nanoparticles, especially Ag and Cu nanoparticles, exhibit promising bactericidal activities against both gram-positive and gram-negative bacteria. 12,13 For example, Natanamurugaraj et al 14 represented the antibacterial activity of Ag nanoparticles against P. aeruginosa and S. aureus.…”

Section: Introductionmentioning

confidence: 99%

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Preparation, characterization, and antibacterial activity of chitosan/silicone rubber filled zeolite, silver, and copper nanocomposites againstPseudomonas aeruginosaand methicillin‐resistantStaphylococcus aureus

Rezazadeh

Kianvash

2021

J of Applied Polymer Sci

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The ongoing emergence of antibiotic‐resistant bacteria has become one of the biggest threats to global health and development today. Pseudomonas aeruginosa and methicillin‐resistant Staphylococcus aureus (MRSA) are important antibiotic‐resistant bacteria due to their increasing resistance to a broad array of antimicrobial agents. Herein, we developed a novel antibacterial nanocomposite based on chitosan and liquid silicone rubber filled zeolite‐A, Ag, and Cu nanoparticles with remarkable antibacterial activity against P. aeruginosa and MRSA. The antibacterial activity of the nanocomposite was studied by disc diffusion and broth culture methods. Besides, the mechanical properties, wetting behavior, and chemical structure of the present nanocomposite were also investigated. The results exhibited that the inhibition zone diameter of the nanocomposite for P. aeruginosa and MRSA were 40 and 27 mm, respectively. It also took approximately 1 h to inhibit the growth of the tested bacteria. The nanocomposite sample with a thickness of around 1 mm showed an elastic elongation of nearly 49% and a contact angle of roughly 120°. Thus, the present nanocomposite was found to be useful in killing and inhibiting the growth of P. aeruginosa and MRSA, and it could also be qualified as a superior elastic and hydrophobic material.

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Section: Resultsmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%