Flexible Charge Balanced Stimulator With 5.6 fC Accuracy for 140 nC Injections

Nag, Sayan; Jia, Xiaofeng; Thakor, Nitish V.; Sharma, Dinesh K.

doi:10.1109/tbcas.2012.2205574

Cited by 35 publications

(15 citation statements)

References 33 publications

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“…Charge balanced waveforms are important for electrical stimulation 93 , whereas in optical stimulation, which is usually highly efficient, it is important to limit the stimulus duration. For example, an edge detector can be used to produce a specific pulse width compatible with optical stimulation 92 (Fig.…”

Section: Methods For Encoding Biomimetic Datamentioning

confidence: 99%

Pursuing prosthetic electronic skin

2016

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Skin plays an important role in mediating our interactions with the world. Recreating the properties of skin using electronic devices could have profound implications for prosthetics and medicine. The pursuit of artificial skin has inspired innovations in materials to imitate skin's unique characteristics, including mechanical durability and stretchability, biodegradability, and the ability to measure a diversity of complex sensations over large areas. New materials and fabrication strategies are being developed to make mechanically compliant and multifunctional skin-like electronics, and improve brain/machine interfaces that enable transmission of the skin's signals into the body. This Review will cover materials and devices designed for mimicking the skin's ability to sense and generate biomimetic signals.

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Section: Methods For Encoding Biomimetic Datamentioning

confidence: 99%

Pursuing prosthetic electronic skin

2016

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“…Study of stimulus artifact suppression was performed with custom built stimulators [29] and DC coupled amplifiers using instrumentation (differential) amplifier front-ends (unlike capacitor coupled [30]), with the same characteristics as mentioned earlier. Resistor-capacitor (RC) based equivalent electrode interface model was used as a load.…”

Section: A Electrical Characterizationmentioning

confidence: 99%

Sensing of Stimulus Artifact Suppressed Signals From Electrode Interfaces

et al. 2015

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Stimulus artifacts inhibit reliable acquisition of biological evoked potentials for several milliseconds if an electrode contact is utilized for both electrical stimulation and recording purposes. This hinders the measurement of evoked short-latency biological responses, which is otherwise elicited by stimulation in implantable prosthetic devices. We present an improved stimulus artifact suppression scheme using two electrode simultaneous stimulation and differential readout using high-gain amplifiers. Substantial reduction of artifact duration has been shown possible through the common-mode rejection property of an instrumentation amplifier for electrode interfaces. The performance of this method depends on good matching of electrode-electrolyte interface properties of the chosen electrode pair. A novel calibration algorithm has been developed that helps in artificial matching of impedance and thereby achieves the required performance in artifact suppression. Stimulus artifact duration has been reduced down to 50 µs from the stimulationcum-recording electrodes, which is ∼6× improvement over the present state of the art. The system is characterized with emulated resistor-capacitor loads and a variety of in-vitro metal electrodes dipped in saline environment. The proposed method is going to be useful for closed-loop electrical stimulation and recording studies, such as bidirectional neural prosthesis of retina, cochlea, brain, and spinal cord.Index Terms-Stimulus artifact suppression, biphasic constant current stimulator, electrode-electrolyte interface, instrumentation and differential amplifier.

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“…The implantable muscle stimulation system consists of a charge balanced stimulator front-end [6], [7] and the platinum-iridium (Pt-Ir) electrodes, while the control, the energy harvesting and the data transfer blocks are exactly same as that of the recording system. Stimulation commands are sent to the implanted site by the data transceiver, which are decoded by the control logic.…”

Section: Implantable System Architecturementioning

confidence: 99%

“…A biphasic control voltage is applied at its input. The electrode current is regulated by the floating current source and its direction is determined by the polarity of input voltage and corresponding diodes in forward or reverse biased [6].…”

Section: Implantable System Architecturementioning

confidence: 99%

Neural prosthesis for motor function restoration in upper limb extremity

Nag

Jagadeesan

et al. 2014

2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings

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Restoration of motor function in cases of peripheral nerve injury is a challenging problem. Although peripheral nerves do regenerate, the time required for peripheral nerves to regenerate often causes atrophy to occur in the muscles before they can be re-innervated. This paper presents a solution through proximal recording of nerve signals and distal muscle stimulation. A fully implantable hardware architecture is described that can be operated by means of inductive power and MICS band data transmission schemes. Preliminary experiments and validation studies are reported with non-human primates based on recordings in the median nerve, stimulation of hand muscles, and task decoding and classification. This approach shows promise in creating a neural prosthesis capable of restoring hand movements in patients with upper limb peripheral nerve injuries.

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Flexible Charge Balanced Stimulator With 5.6 fC Accuracy for 140 nC Injections

Cited by 35 publications

References 33 publications

Pursuing prosthetic electronic skin

Pursuing prosthetic electronic skin

Sensing of Stimulus Artifact Suppressed Signals From Electrode Interfaces

Neural prosthesis for motor function restoration in upper limb extremity

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