Flexible carbon nanotubes electrode for neural recording

Lin, Chia‐Jung; Lee, Yu-Tao; Yeh, Shih-Rung; Fang, Weileun

doi:10.1016/j.bios.2009.02.005

Cited by 63 publications

(49 citation statements)

References 34 publications

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“…Lin and colleagues [116] were the first researchers to grow CNTs electrode arrays on a silicon substrate, transfer it onto a flexible and biocompatible polymeric film (Fig. 1), and then successfully record the APs of crayfish nerve cords.…”

Section: Reviewmentioning

confidence: 99%

Carbon-based smart nanomaterials in biomedicine and neuroengineering

Monaco¹,

Giugliano²

2014

Beilstein J. Nanotechnol.

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SummaryThe search for advanced biomimetic materials that are capable of offering a scaffold for biological tissues during regeneration or of electrically connecting artificial devices with cellular structures to restore damaged brain functions is at the forefront of interdisciplinary research in materials science. Bioactive nanoparticles for drug delivery, substrates for nerve regeneration and active guidance, as well as supramolecular architectures mimicking the extracellular environment to reduce inflammatory responses in brain implants, are within reach thanks to the advancements in nanotechnology. In particular, carbon-based nanostructured materials, such as graphene, carbon nanotubes (CNTs) and nanodiamonds (NDs), have demonstrated to be highly promising materials for designing and fabricating nanoelectrodes and substrates for cell growth, by virtue of their peerless optical, electrical, thermal, and mechanical properties. In this review we discuss the state-of-the-art in the applications of nanomaterials in biological and biomedical fields, with a particular emphasis on neuroengineering.

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Section: Reviewmentioning

confidence: 99%

Carbon-based smart nanomaterials in biomedicine and neuroengineering

Monaco¹,

Giugliano²

2014

Beilstein J. Nanotechnol.

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“…The evoked APs were optically identified by measuring variance in intracellular calcium using Fluo-4, a calcium indicator. Later, vertically aligned CNTs were embedded in parylene-C to create a flexible MEA (Lin et al, 2009). The flexible CNT-MEAs were able to successfully record spontaneous spikes from the crayfish nerve cord.…”

Section: Stimulation and Recording In Vitro Via Cnt Substratesmentioning

confidence: 99%

Implantable Electrodes with Carbon Nanotube Coatings

Minnikanti¹,

Peixoto²

2011

Carbon Nanotubes Applications on Electron Devices

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“…The requirements for successful regenerative engineering are neurorestoration, neurogenesis, reconnection of neuronal circuits, and neuroplasticity [92,116]. It has been demonstrated for the first time by Mattson and colleagues that neurons of rat hippocampus could be grown on MWCNT layer functionalized with 4-hydroxynonenal [117].…”

Section: Carbon Nanotubes In Neuroengineering In Ischemic Stroke and mentioning

confidence: 99%

“…Nanotechnological advances for neurotrophin delivery systems are promising regarding their ability to activate neurotrophin signalling for neuroprotection and neuroregeneration [63]. Neurotrophins are indispensable for the development and functions of neurons and can be delivered to their site of action by CNTs [92,93].…”

Section: Carbon Nanotubes As Cns Drug Delivery Vehicles For the Treatmentioning

confidence: 99%

“…The success in this work inspired Lin and colleagues to modify it for easy use. The system was applied in recording the action potentials of nerves from crayfish [92]. There is a limited understanding of the interaction of CNTs and the CNS and their potential application requires further investigation as a result [93].…”

Section: Carbon Nanotubes As Electrochemical Biosensors In Neurosciencementioning

confidence: 99%

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Diagnosis and Treatment of Neurological and Ischemic Disorders Employing Carbon Nanotube Technology

Komane

Choonara

Toit

et al. 2016

Journal of Nanomaterials

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Extensive research on carbon nanotubes has been conducted due to their excellent physicochemical properties. Based on their outstanding physicochemical properties, carbon nanotubes have the potential to be employed as theranostic tools for neurological pathologies such as Alzheimer’s disease and Parkinson’s disease including ischemic stroke diagnosis and treatment. Stroke is currently regarded as the third root cause of death and the leading source of immobility around the globe. The development and improvement of efficient and effective procedures for central nervous system disease diagnosis and treatment is necessitated. The main aim of this review is to discuss the application of nanotechnology, specifically carbon nanotubes, to the diagnosis and treatment of neurological disorders with an emphasis on ischemic stroke. Areas covered include the conventional current diagnosis and treatment of neurological disorders, as well as a critical review of the application of carbon nanotubes in the diagnosis and treatment of ischemic stroke, covering areas such as functionalization of carbon nanotubes and carbon nanotube-based biosensors. A broad perspective on carbon nanotube stimuli-responsiveness, carbon nanotube toxicity, and commercially available carbon nanotubes is provided. Potential future studies employing carbon nanotubes have been discussed, evaluating their extent of advancement in the diagnosis and treatment of neurological and ischemic disorders.

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Flexible carbon nanotubes electrode for neural recording

Cited by 63 publications

References 34 publications

Carbon-based smart nanomaterials in biomedicine and neuroengineering

Carbon-based smart nanomaterials in biomedicine and neuroengineering

Implantable Electrodes with Carbon Nanotube Coatings

Diagnosis and Treatment of Neurological and Ischemic Disorders Employing Carbon Nanotube Technology

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