Flexible and Soft Materials and Devices for Neural Interface

Castagnola, Elisa; Zheng, Xin; Cui, Xiufang

doi:10.1007/978-981-15-2848-4_5-1

Cited by 2 publications

(2 citation statements)

References 254 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 77 , 78 ] MEAs with flexible substrates can help to minimize the mechanical trauma caused by micromotion between the probe and the surrounding tissue. [ 21 , 79 ] The flexibility of a device is not only affected by the materials’ modulus but also by the geometry of the shank. [ 21 ] Although polyimide has Young's modulus of ≈2 GPa, by making the film thin, the flexibility is increased so that MEAs can move with tissue to minimize relative micromotion.…”

Section: Resultsmentioning

confidence: 99%

PEDOT/CNT Flexible MEAs Reveal New Insights into the Clock Gene's Role in Dopamine Dynamics

Wu,

Castagnola,

McClung

et al. 2024

Advanced Science

Self Cite

View full text Add to dashboard Cite

Substantial evidence has shown that the Circadian Locomotor Output Cycles Kaput (Clock) gene is a core transcription factor of circadian rhythms that regulates dopamine (DA) synthesis. To shed light on the mechanism of this interaction, flexible multielectrode arrays (MEAs) are developed that can measure both DA concentrations and electrophysiology chronically. The dual functionality is enabled by conducting polymer PEDOT doped with acid‐functionalized carbon nanotubes (CNT). The PEDOT/CNT microelectrode coating maintained stable electrochemical impedance and DA detection by square wave voltammetry for 4 weeks in vitro. When implanted in wild‐type (WT) and Clock mutation (MU) mice, MEAs measured tonic DA concentration and extracellular neural activity with high spatial and temporal resolution for 4 weeks. A diurnal change of DA concentration in WT is observed, but not in MU, and a higher basal DA concentration and stronger cocaine‐induced DA increase in MU. Meanwhile, striatal neuronal firing rate is found to be positively correlated with DA concentration in both animal groups. These findings offer new insights into DA dynamics in the context of circadian rhythm regulation, and the chronically reliable performance and dual measurement capability of this technology hold great potential for a broad range of neuroscience research.

show abstract

Section: Resultsmentioning

confidence: 99%

PEDOT/CNT Flexible MEAs Reveal New Insights into the Clock Gene's Role in Dopamine Dynamics

Wu,

Castagnola,

McClung

et al. 2024

Advanced Science

Self Cite

View full text Add to dashboard Cite

show abstract

“…Several improvement methods have been reported to mitigate these challenges in neuromodulation. Reducing implant sizes to the sub-cellular scale, using flexible materials in device construction, and developing wireless transmission and packaging techniques have all contributed to improving tissue compatibility, reducing mechanical stress, and enhancing long-term biocompatibility [34][35][36][37][38][39][40][41]. Additionally, the development of wireless optogenetic interfaces and new opsins responsive to near-infrared (NIR) light has enabled the modulation of deep subcortical structures, thereby increasing the spatial precision of light-based neuromodulation [42][43][44].…”

Section: Introductionmentioning

confidence: 99%

Potential of Photoelectric Stimulation with Ultrasmall Carbon Electrode on Neural Tissue: New Directions in Neuromodulation Technology Development

Chen,

Wu,

Krahe

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

ObjectiveNeuromodulation technologies have gained considerable attention for its clinical potential in treating neurological disorders and their capacity to advance cognition research. Nevertheless, traditional neuromodulation methods such as electrical stimulation and optogenetics manipulation currently experience technical and biological challenges that hinge their therapeutic potential and chronic research applications. Recently, a promising alternative neuromodulation approach based on the photoelectric effect has emerged. This approach is capable of generating electrical pulses when exposed to near-infrared (NIR) light and allows modulation of neuronal activity without the need for genetic alterations. In this study, we investigate a variety of design strategies aimed at enhancing photoelectric stimulation using minimally invasive, ultrasmall, untethered carbon electrodes.ApproachA multiphoton laser was employed as the NIR light source. Benchtop investigations were conducted using a three-electrode setup, and chronopotentiometry was used to record photo-stimulated voltage. Forin vivoevaluation, we used Thy1-GCaMP6s mice with acute implantation of ultrasmall carbon electrodes.Main resultsWe revealed the beneficial effects of high duty-cycle laser scanning and photovoltaic polymer interfaces on the photo-stimulated voltages of ultrasmall carbon electrodes. Additionally, we demonstrated the promising potential of carbon-based diamond electrodes for photoelectric stimulation and examined the application of photoelectric stimulation in precise chemical delivery by loading mesoporous silica nanoparticles (SNPs) co-deposited with polyethylenedioxythiophene (PEDOT).SignificanceThese findings on photoelectric stimulation utilizing ultrasmall carbon electrodes underscore its immense potential for advancing the next generation of neuromodulation technology. This approach offers the opportunity to effectively modulate neural tissue while minimizing invasive implantation-related injuries in freely moving subjects, which hold significant promise for a wide range of applications in neuroscience research and clinical settings.

show abstract

Flexible and Soft Materials and Devices for Neural Interface

Cited by 2 publications

References 254 publications

PEDOT/CNT Flexible MEAs Reveal New Insights into the Clock Gene's Role in Dopamine Dynamics

PEDOT/CNT Flexible MEAs Reveal New Insights into the Clock Gene's Role in Dopamine Dynamics

Potential of Photoelectric Stimulation with Ultrasmall Carbon Electrode on Neural Tissue: New Directions in Neuromodulation Technology Development

Contact Info

Product

Resources

About