Flexible and highly sensitive methadone sensor based on gold nanoparticles/polythiophene modified carbon cloth platform

Khorablou, Zeynab; Shahdost-fard, Faezeh; Razmi, Habib

doi:10.1016/j.snb.2021.130284

Cited by 26 publications

(12 citation statements)

References 54 publications

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“…The results also indicate Cs@MoS2-Pd NPs had been successfully prepared. The characterization of Cs@MoS NPs by FTIR, XRD, Raman, and Zeta potential in Figure S1 [37][38][39][40][41][42] and the specific ysis are in Supplementary Materials, which results are also proved that the Cs@Mo NPs had been successfully prepared.…”

Section: Characterization Of Cs@mos 2 -Pd Nps Nanocompositementioning

confidence: 70%

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Palladium Nanoparticle-Modified Carbon Spheres @ Molybdenum Disulfide Core-Shell Composite for Electrochemically Detecting Quercetin

Pei

Feng

et al. 2022

Chemosensors

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Quercetin (QR), abundant in plants, is used to treat colitis and gastric ulcer and is also a promising anticancer agent. To quantificationally detect QR, a sensitive electrochemical sensor was fabricated by palladium nanoparticles loaded on carbon sphere @ molybdenum disulfide nanosheet core-shell composites (Cs@MoS2-Pd NPs). The Cs@MoS2-Pd NPs worked to remedy the shortcomings of MoS2 and exhibited good catalytic activity to QR. The oxidation reaction of QR on Cs@MoS2-Pd NPs/GCE involved two electrons and two protons. Furthermore, the molecular surface for electrostatic potential, Laplacian bond order, and Gibbs free energy were computationally simulated to speculate the order and site of the oxidation of QR. The results showed that the 4′ O–H and 3′ O–H broke successively during the oxidation reaction. When the concentration of QR was within 0.5 to 12 μM, the fabricated sensor could achieve linear detection, and the detection limit was 0.02 μM (S/N = 3). In addition, the sensor possessed good selectivity, repeatability, and stability, which has a broad prospect in practical application.

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Section: Characterization Of Cs@mos 2 -Pd Nps Nanocompositementioning

confidence: 70%

“…By taking the square root of time, Figure 4D is obtained. The effective area (A) can be calculated by the slope of the line via the Anson equation [41]:…”

Section: The Study Of Electrocatalysis Oxidation To Qrmentioning

confidence: 99%

Palladium Nanoparticle-Modified Carbon Spheres @ Molybdenum Disulfide Core-Shell Composite for Electrochemically Detecting Quercetin

Pei

Feng

et al. 2022

Chemosensors

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“…An antibody against methadone was used in a lateral flow test of human sweat (limited to a single timepoint) 13 . Electrochemical methods provide continuous measurements but vary in selectivity against other opioids 14-16 and, in all cases, cannot be used for subcellular measurements. A pioneering de novo protein design campaign for an opioid sensor, binding of fentanyl produced a conformational switch in a transcription factor 17 but required a cellular readout and hours-to-days temporal resolution.…”

mentioning

confidence: 99%

Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-methadone for Use in Cells, Organelles, and Biofluids

Muthusamy

Kim

Virgil

et al. 2022

Preprint

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We report a reagentless, intensity-based S-methadone fluorescent sensor, iS-methadoneSnFR, consisting of a circularly permuted GFP inserted within the sequence of a mutated bacterial periplasmic binding protein (PBP). We used directed evolution to convert a previously reported nicotine-binding PBP to a selective S-methadone-binding sensor, via three mutations in the second shell and hinge regions of the PBP. iS-methadoneSnFR displays sensitivity across the pharmacologically relevant range and selectivity against endogenous analytes and other opioids. Robust iS-methadoneSnFR responses in human sweat and saliva and mouse serum enable diagnostic uses. Genetic encoding and imaging in mammalian demonstrated the acid trapping of S-methadone in the Golgi apparatus where opioid receptors can signal. This work shows a straightforward strategy in adapting existing PBPs to serve real-time applications ranging from subcellular to personal pharmacokinetics.

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“…Methadone (MET), also known as 6-dimethylamino-4, 4-diphenyl-3-heptanone, is a potent synthetic analgesic used as an opioid for maintenance therapy in the treatment of heroin and morphine addicts and for the treatment of chronic pain management 3 , 4 . However, research has also shown that MET can be addictive, and addiction to MET is increasing in various societies 5 , 6 . According to the study results, MOR and MET have almost similar pharmacological properties, and overdose of MOR and MET can lead to premature death in people 7 .…”

Section: Introductionmentioning

confidence: 99%

Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration

Habibi

Ghasemi

Badiei

et al. 2022

Sci Rep

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For the first time, a sensitive electrochemical sensor using a glassy carbon electrode modified with CMK-5 Ordered mesoporous carbon was fabricated for simultaneous analysis of morphine and methadone. Modern electrochemical FFT-SWV techniques and partial least-squares as a multivariable analysis were used in this method. CMK-5 nanostructures were characterized by field emission scanning electron microscopy, transmission electron microscopy, X-ray diffraction analysis, and Raman spectroscopy. Variables such as accumulation time and pH for the proposed sensor were optimized before quantitative analysis. To train the proposed sensor, standard mixtures of morphine (MOR), and methadone (MET) were prepared in the established linear ranges of the analyzes. The results obtained from training samples were used for PLS modeling. The efficiency of the model was determined using test and real matrix samples. The root mean square error of prediction and the squared correlation coefficients (R2p) for MET and MOR were estimated to be 0.00772 and 0.00892 and 0.948 to 0.990, respectively. The recoveries in urine samples were reported to be 97.0 and 105.6% for both MOR and MET, respectively.

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Flexible and highly sensitive methadone sensor based on gold nanoparticles/polythiophene modified carbon cloth platform

Cited by 26 publications

References 54 publications

Palladium Nanoparticle-Modified Carbon Spheres @ Molybdenum Disulfide Core-Shell Composite for Electrochemically Detecting Quercetin

Palladium Nanoparticle-Modified Carbon Spheres @ Molybdenum Disulfide Core-Shell Composite for Electrochemically Detecting Quercetin

Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-methadone for Use in Cells, Organelles, and Biofluids

Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration

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