“…[1] Among them isoxazole one of the five-member heterocyclic compounds in which nitrogen and oxygen both heteroatoms are present at the adjacent position. Isoxazole derivatives have been found to be associated with diverse biological activities [2] such as selective agonists in human cloned dopamine D4 receptors, [3] exhibit GABA receptor antagonist, [4] analgesic, [5] antiinflammatory, [6] antimicrobial, [7] antifungal, [8] COX-2 inhibitory, [9] antitumor, [10] anti-HIV, [11] anti-cancer activity, [12] antitryanosomal activity [13] and anti-leishmanial activities. [14] The marketed drugs of isoxazole such as Leflunomide, Valedecoxib, Acetylsulfisoxazole, Drazoxol, Zonisamide, Gabodaxol, Cycloserine, Ibotenic acid, Sulfamethoxazole and Isocarboxazid have great medicinal values.…”