Flexibility in starting ovarian stimulation at different phases of the menstrual cycle for treatment of infertile women with the use of in vitro fertilization or intracytoplasmic sperm injection

Qin, Ning-Xin; Chen, Qiuju; Hong, Qingqing; Cai, Renfei; Gao, Hongyuan; Wang, Yun; Sun, Lihua; Zhang, Shaozhen; Guo, Haiyan; Fu, Yonglun; Ai, Ai; Tian, Hui; Lyu, Qifeng; Daya, Salim; Kuang, Yanping

doi:10.1016/j.fertnstert.2016.04.006

Cited by 62 publications

(48 citation statements)

References 17 publications

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“…Transvaginal ultrasound‐guided oocyte retrieval was performed 34‐36 hours after the trigger. All follicles with diameters >10 mm were aspirated …”

Section: Methodsmentioning

confidence: 99%

“…According to the criteria described by Cummins et al, high‐quality embryos (including grade 1 and grade 2 8‐cell embryos) were frozen via vitrification on the 3rd day after oocyte retrieval, and low‐quality embryos were placed in extended culture. Subsequently, blastocysts with good morphological grades were frozen on day 5 or 6 of culture …”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Progestin‐primed ovarian stimulation with or without clomiphene citrate supplementation in normal ovulatory women undergoing in vitro fertilization/intracytoplasmic sperm injection: A prospective randomized controlled trial

Liu

Chen

et al. 2018

Clinical Endocrinology

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“…Transvaginal ultrasound‐guided oocyte retrieval was performed 34‐36 hours after the trigger. All follicles with diameters >10 mm were aspirated …”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Progestin‐primed ovarian stimulation with or without clomiphene citrate supplementation in normal ovulatory women undergoing in vitro fertilization/intracytoplasmic sperm injection: A prospective randomized controlled trial

Liu

Chen

et al. 2018

Clinical Endocrinology

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“…As there was only one opportunity to use fresh testicular spermatozoa, the COS protocol was carefully planned: specifically, the most optimal method for collecting sufficient MII eggs, while avoiding the risk of OHSS. Moreover, the COS protocols with a low risk of being cancelled on the day of the micro‐TESE were considered, as well as the GnRH protocol and flexibility in starting the ovarian‐stimulation protocol …”

Section: Discussionmentioning

confidence: 99%

“…the risk of OHSS. Moreover, the COS protocols with a low risk of being cancelled on the day of the micro-TESE were considered, as well as the GnRH protocol and flexibility in starting the ovarianstimulation protocol 29. Regarding flexibility in starting the ovarian-stimulation protocol, a previous report showed the starting times of ovulation induction TA B L E 5 Clinical course of the female partner of the patients with non-mosaic Klinefelter's syndrome , two pronuclei and two polar bodies (normal fertilized oocyte); AID, artificial insemination using donor semen; ART, assisted reproductive technology; ET, embyo transfer, hCG, human chorionic gonadotropin; hMG, human menopausal gonadotropin, MII, metaphase stage II.…”

mentioning

confidence: 99%

Microdissection testicular sperm extraction in five Japanese patients with non‐mosaic Klinefelter's syndrome

Chihara

Ogi

Ishiguro

et al. 2018

Reprod Medicine & Biology

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CasesMicrodissection testicular sperm extraction (micro‐TESE) was performed on five Japanese men with non‐mosaic Klinefelter's syndrome (KS) and non‐obstructive azoospermia in the authors' department. Here is reported the operative results and partner's clinical course for two cases where spermatozoa could be acquired. Also encountered was a man with non‐mosaic KS with the partial deletion of azoospermia factor (AZF)b. Because this is rare, it is reported in detail in the context of the previous literature. This case series describes the first experience of micro‐TESE by gynecologists in the current department.OutcomeThe egg collection date was adjusted to the micro‐TESE day by using the modified ultra‐long method. Intracytoplasmic sperm injection (ICSI) was implemented for two men whose spermatozoa were acquired by micro‐TESE, with these progressing to the blastocyst stage. Subsequently, one case conceived after the transfer of fresh embryos and a healthy baby was delivered. However, spermatozoa could not be retrieved from the man with non‐mosaic KS who was harboring the partial deletion of AZFb.ConclusionThese findings suggest that ovulation induction by using the modified ultra‐long method with micro‐TESE and ICSI on the same day represents an effective treatment option for men with non‐mosaic KS. As there are cases where AZF deletion is recognized among patients with non‐mosaic KS, screening before micro‐TESE is strongly recommended.

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“…All follicles with diameters of more than 10 mm were retrieved. 8 The process of oocytes fertilization was carried out in vitro, by conventional insemination or intracytoplasmic sperm injection, depending on semen quality. 9 On the third day, the degree of embryonic fragmentation, the regularity and number of blastomeres of the embryos were examined according to Cummins et al's criteria.…”

Section: Ovarian Stimulation and Embryo Culture Pposmentioning

confidence: 99%

<p>Comparison Between PPOS and GnRHa-Long Protocol in Clinical Outcome with the First IVF/ICSI Cycle: A Randomized Clinical Trial</p>

Xi¹,

Tao²,

Qiu³

et al. 2020

CLEP

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Purpose: To investigate whether progestin-primed ovarian stimulation (PPOS) can be an alternative as gonadotrophin-releasing hormone agonist (GnRHa) long protocol for infertile women with normal ovarian reserve during IVF/ICSI. Methods: A prospective randomized controlled trial (RCT) including 257 patients was conducted between 1 August 2017 to 1 January 2018. Computerized randomization was performed to assign participants into two treatment groups at a 1:1 ratio: PPOS (130 patients) or GnRHa long protocol (127 patients) followed by their first IVF/ICSI with fresh/frozen embryo transfer. The primary outcome was the number of oocytes retrieved. Patients with normal ovarian reserve undergoing their first IVF/ICSI procedure were included. The embryological and clinical outcomes were measured. Only the first embryo transfer cycle was followed-up. Results: Basic characteristics such as infertility duration, age, and body mass index (BMI) were comparable in both groups. No significant difference was found in the number (mean ± SD) oocytes retrieved [11.8 ± 6.5 for PPOS vs 11.3 ± 5.6 for GnRHa long protocol] or viable embryos [4.5 ± 3.0 for PPOS vs 4.2 ± 2.9 for GnRHa long protocol] between the groups. No patient from either group experienced a premature LH surge during the whole process of ovarian stimulation. Besides, there was no moderate or severe ovarian hyperstimulation syndrome during the ovarian stimulation in PPOS group while three patients suffered it in the GnRHa long protocol group. There was no significant difference in the clinical pregnancy rate of the first embryos transfer cycle between the two groups. Conclusion: PPOS in combination with embryo cryopreservation as an ovarian stimulation regimen was as effective as GnRHa long protocol during controlled ovarian stimulation (COH) under different endocrinal mechanisms. It can also achieve comparable embryological and clinical outcomes while reducing the incidence of moderate and severe ovarian hyperstimulation syndrome (OHSS) and HMG dosage. It can be an alternative of the treatments for infertile patients with normal ovarian reserve undergoing IVF as well as traditional protocols.

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Flexibility in starting ovarian stimulation at different phases of the menstrual cycle for treatment of infertile women with the use of in vitro fertilization or intracytoplasmic sperm injection

Abstract: ChiCTR-OPN-15007332.

Cited by 62 publications

References 17 publications

Progestin‐primed ovarian stimulation with or without clomiphene citrate supplementation in normal ovulatory women undergoing in vitro fertilization/intracytoplasmic sperm injection: A prospective randomized controlled trial

Progestin‐primed ovarian stimulation with or without clomiphene citrate supplementation in normal ovulatory women undergoing in vitro fertilization/intracytoplasmic sperm injection: A prospective randomized controlled trial

Microdissection testicular sperm extraction in five Japanese patients with non‐mosaic Klinefelter's syndrome

<p>Comparison Between PPOS and GnRHa-Long Protocol in Clinical Outcome with the First IVF/ICSI Cycle: A Randomized Clinical Trial</p>

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