Fletcher factor deficiency in a woman requiring emergency caesarean section

Odumosu, Modupe; Yoong, Wai; Fakokunde, A.

doi:10.1080/01443610902952554

Cited by 7 publications

(6 citation statements)

References 5 publications

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“…They belonged to 56 separate kindreds [10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47]. A thrombotic event was reported in 9 of these patients belonging to 6 different families (table 1) [5,16,22,23,24,28].…”

Section: Resultsmentioning

confidence: 99%

Thrombotic Events in Patients with Congenital Prekallikrein Deficiency: A Critical Evaluation of All Reported Cases

et al. 2010

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The occurrence of thrombotic events in patients with congenital bleeding conditions has received considerable attention in recent years. The same is true for asymptomatic defects of factors of the contact phase of blood coagulation, mainly FXII. Anecdotal reports on thrombosis in patients with prekallikrein deficiency have occasionally been reported. These involved both arterial and venous thrombosis. The purpose of the present article is to analyze the stories and the clinical pictures of all 75 cases of prekallikrein deficiency published so far. Among these patients were 9 with thrombosis, 6 arterial (myocardial infarction and ischemic stroke) and 3 venous (deep vein thrombosis with or without pulmonary embolism). In 6 cases acquired thrombosis risk factors were present; in 2 cases no associated risk factors were present and in 1 case no information was supplied in this regard. One patient who presented both a stroke and a pulmonary embolism had a fatal outcome. The article clearly indicates that prekallikrein deficiency does not protect from thrombosis in spite of the severe in vitro coagulation defect.

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Section: Resultsmentioning

confidence: 99%

Thrombotic Events in Patients with Congenital Prekallikrein Deficiency: A Critical Evaluation of All Reported Cases

et al. 2010

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“…In addition, 3 Africans (one African-Carribbean, one African-European, and one African African) were found among the 65 papers that dealt with PK deficiency published outside the United States. [21][22][23] No patient, but two, showed a bleeding tendency. In one case, reported by Waddell et al 19 PK deficiency was associated with chronic lymphocytic leukemia.…”

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confidence: 99%

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confidence: 99%

Increased Prevalence of Reported Cases of Congenital Prekallikrein Deficiency Among African Americans as Compared With the General Population of the United States

Girolami

Ferrari

Cosi

et al. 2020

Clin Appl Thromb Hemost

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“…4 However, rare cases are associated with recurrent mucosal bleeding, 5 hypertension, 6 recurrent cerebrovascular accidents, 7 recurrent pregnancy loss, 8 or failure to progress during labor. 9 Interference with the in vitro measurement of ACT and PTT could cause significant difficulties during the perioperative and postoperative monitoring of anticoagulation that is routinely done with cardiac surgery. The potential for interference with the measurement of ACT and PTT emphasizes the importance of physician understanding of the limitations of laboratory testing.…”

Section: Case Reportmentioning

confidence: 99%

Prolonged Activated Clotting Time Immediately Prior to Open Cardiac Surgery

Baker

Kiefer

Carollo

et al. 2018

TOJ

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Background: Prekallikrein deficiency is an extremely rare disorder in which functional prekallikrein in the plasma is reduced or absent. Case Report: We present the case of a 15-year-old male with prolonged activated clotting time incidentally noted preoperatively prior to repair of an atrial septal defect. The patient was subsequently found to have prekallikrein (Fletcher factor) deficiency. He successfully underwent open cardiac surgical repair after fresh frozen plasma was administered at a dose of 15 mL/kg 1 hour prior to the start of the procedure. Conclusion: History and routine preoperative evaluations of complete blood count, partial thromboplastin time, prothrombin time, and platelet function analysis failed to detect any abnormalities, but a prolongation of activated clotting time identified by the anesthesiologist led to specialized testing and a diagnosis of Fletcher factor deficiency. The patient tolerated the open-heart surgery well without any significant hematologic intervention or complications.

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Fletcher factor deficiency in a woman requiring emergency caesarean section

Cited by 7 publications

References 5 publications

Thrombotic Events in Patients with Congenital Prekallikrein Deficiency: A Critical Evaluation of All Reported Cases

Thrombotic Events in Patients with Congenital Prekallikrein Deficiency: A Critical Evaluation of All Reported Cases

Increased Prevalence of Reported Cases of Congenital Prekallikrein Deficiency Among African Americans as Compared With the General Population of the United States

Prolonged Activated Clotting Time Immediately Prior to Open Cardiac Surgery

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