Flaxseed oil–trastuzumab interaction in breast cancer

Mason, Julie K.; Chen, Jianmin; Thompson, Lilian U.

doi:10.1016/j.fct.2010.05.052

Cited by 33 publications

(22 citation statements)

References 26 publications

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“…The role played by ERK signaling in the apoptotic response of the cancer cells only after BAD-NE treatment could be related to the combined effect of H 2 S-donor and ALA. Most of the in vitro and in vivo studies show a reduction in cell/tumor growth from ALA and ALA-rich flaxseed oil treatment [118–121], although this is not confirmed by other reports that show minimal effects [122, 123]. In our studies, the presence of ALA (at 50 μM) in the NEs seems to reduce the anti-proliferative effect in cancer cells when compared to BD-NEs treatment after 24 h (Figure 7B), but it seems to increase after 48 h (Figures 6D and 7B).…”

Section: Resultsmentioning

confidence: 90%

H2S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair

et al. 2016

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The improvement of solubility and/or dissolution rate of poorly soluble natural compounds is an ideal strategy to make them optimal candidates as new potential drugs. Accordingly, the allyl sulfur compounds and omega-3 fatty acids are natural hydrophobic compounds that exhibit two important combined properties: cardiovascular protection and antitumor activity. Here, we have synthesized and characterized a novel formulation of diallyl disulfide (DADS) and α-linolenic acid (ALA) as protein-nanoemulsions (BAD-NEs), using ultrasounds. BAD-NEs are stable over time at room temperature and show antioxidant and radical scavenging property. These NEs are also optimal H2S slow-release donors and show a significant anti-proliferative effect on different human cancer cell lines: MCF-7 breast cancer and HuT 78 T-cell lymphoma cells. BAD-NEs are able to regulate the ERK1/2 pathway, inducing apoptosis and cell cycle arrest at the G0/G1 phase. We have also investigated their effect on cell proliferation of human adult stem/progenitor cells. Interestingly, BAD-NEs are able to improve the Lin– Sca1+ human cardiac progenitor cells (hCPC) proliferation. This stem cell growth stimulation is combined with the expression and activation of proteins involved in tissue-repair, such as P-AKT, α-sma and connexin 43. Altogether, our results suggest that these antioxidant nanoemulsions might have potential application in selective cancer therapy and for promoting the muscle tissue repair.

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Section: Resultsmentioning

confidence: 90%

H2S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair

et al. 2016

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“…Studies on the effect of ALA taken concurrently with BC drugs, and the exact mechanism of effect are also of interest. Previous in vivo xenograft studies have shown that ALA-rich flaxseed oil doesn't interfere and actually enhances the effectiveness of trastuzumab and tamoxifen on BT474 and MCF-7 tumors, respectively (10,32), but studies on other BC subtypes have not been done.…”

Section: Discussionmentioning

confidence: 98%

“…A prospective cohort study that did separate EPA, DHA, and ALA intake however found that ALA was the only n-3 PUFA to significantly reduce BC risk (30), highlighting the need for more research attention devoted to ALA and BC. Of the in vitro and in vivo studies conducted to date, most show a reduction in cell/tumor growth from ALA and ALA-rich flaxseed oil treatment (7,8,(31)(32)(33) but others show little or no effect (10,11). None of these studies, however, have directly compared the effect of ALA in different BC subtypes and estrogen environments, both of which may significantly alter ALA effectiveness and explain the inconsistency in ALA and BC research.…”

Section: Introductionmentioning

confidence: 87%

“…Many preclinical studies have shown BC growth reduction from n-3 PUFA supplementation (5)(6)(7)(8), however others (9)(10)(11) and the majority of epidemiological studies show little effect (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25). Several factors may contribute to these inconsistent findings including failure to stratify studies by 1) n-3 PUFA type, 2) BC molecular subtype/cell receptor expression, and 3) hormonal environment/estrogen levels.…”

Section: Introductionmentioning

confidence: 93%

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α-Linolenic Acid Reduces Growth of Both Triple Negative and Luminal Breast Cancer Cells in High and Low Estrogen Environments

Wiggins

Kharotia

Mason

et al. 2015

Nutrition and Cancer

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Flaxseed, rich in α-linolenic acid (ALA), is a complementary breast cancer (BC) therapy; however ALA effectiveness and mechanism are unclear. Variation in cellular expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and estrogen (E2) levels may alter ALA effectiveness. This research determined the effect of ALA on growth, apoptosis, and phospholipid fatty acids of 4 BC cell lines with varying receptor expression ± E2. MCF-7 (ER+/PR+/HER2-), BT-474 (ER+/PR+/HER2+), MDA-MB-231 (ER-/PR-/HER2-) and MDA-MB-468 (ER-/PR-/HER2-) cells were incubated with ALA (50-200 μM) ± 1 nM E2 for 48-72 h. ALA dose-dependently reduced growth, measured by trypan blue exclusion, of all cells (55-80% with 75 μM), and this effect was not altered by E2. ALA (75 μM)+E2 induced apoptosis, measured by flow cytometry (up to 111.2%). Decreased growth and increased apoptosis is related to increased cell phospholipid % ALA (up to 25.1%), measured by gas chromatography. ALA is shown for the first time to reduce cell growth and induce apoptosis regardless of receptor expression and E2 environment, by incorporating into BC phospholipids, supporting the use of ALA and ALA-rich foods as a safe, inexpensive complementary therapy for a wide range of BC.

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“…Nesse contexto, este trabalho teve como objetivo a aplicação de métodos de (Hu et al, 2007;Figueiredo et al, 2017;Johnsson, 2009 ), os quais vêm sendo avaliados em pesquisas clínicas e estudos relacionados a prevenção e tratamento de diversos tipos de cânceres, como câncer de mama (Dabrosin et al, 2002;Mason et al, 2010), de ovários (Eilati et al, 2013), próstata (Kaluza et al, 2009) e outros (Dabrosin et al, 2002). O OEL também é amplamente associado a diminuição do mau colesterol HDL (high density lipoprotein), prevenindo doenças cardiovasculares (Leyva et al, 2011), a manutenção do peso corporal (Pilar et al, 2014) e prevenção a obesidade (Johnsson, 2009 ), assim como prevenção e tratamento de diabetes (Jangale et al, 2013).…”

Section: Lista De Tabelas Tabela 1 -Comparação Dos Níveis De Constituunclassified

Controle de qualidade de óleos de linhaça e ginkgo biloba usando Espectrometria no Infravermelho Médio e ferramentas quimiométricas

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Flaxseed oil–trastuzumab interaction in breast cancer

Cited by 33 publications

References 26 publications

H2S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair

H2S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair

α-Linolenic Acid Reduces Growth of Both Triple Negative and Luminal Breast Cancer Cells in High and Low Estrogen Environments

Controle de qualidade de óleos de linhaça e ginkgo biloba usando Espectrometria no Infravermelho Médio e ferramentas quimiométricas

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