Flaxseed Oil Containing<b><i>α</i></b>-Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice

Han, Hao; Yan, Peipei; Chen, Li; Luo, Cheng; Gao, Hui; Deng, Qianchun; Zheng, Mingming; Shi, Yong; Liu, Liegang

doi:10.1155/2015/958217

Cited by 32 publications

(22 citation statements)

References 56 publications

(49 reference statements)

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“…Results of various research studies have shown that the suppression of atherosclerosis is associated with reduced levels of serum lipids and antioxidant activity. A recent study hat was designed to evaluate the effects of flaxseed oil containing α-linolenic acid ester of plant sterols (ALA-PS) demonstrated that ALA-PS flaxseed oil synergistically interacted in atherosclerosis ameliorating as well as in optimizing overall lipid levels, contracting inflammation, and lowering oxidative stress [ 69 ]. Another animal study suggested that ingestion of oxidized flaxseed oil increases hepatic plasma malondialdehyde (MDA) concentration and is potentially pro-atherogenic.…”

Section: Resultsmentioning

confidence: 99%

Polyunsaturated Fatty Acids and Their Potential Therapeutic Role in Cardiovascular System Disorders—A Review

et al. 2018

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Cardiovascular diseases are described as the leading cause of morbidity and mortality in modern societies. Therefore, the importance of cardiovascular diseases prevention is widely reflected in the increasing number of reports on the topic among the key scientific research efforts of the recent period. The importance of essential fatty acids (EFAs) has been recognized in the fields of cardiac science and cardiac medicine, with the significant effects of various fatty acids having been confirmed by experimental studies. Polyunsaturated fatty acids are considered to be important versatile mediators for improving and maintaining human health over the entire lifespan, however, only the cardiac effect has been extensively documented. Recently, it has been shown that omega-3 fatty acids may play a beneficial role in several human pathologies, such as obesity and diabetes mellitus type 2, and are also associated with a reduced incidence of stroke and atherosclerosis, and decreased incidence of cardiovascular diseases. A reasonable diet and wise supplementation of omega-3 EFAs are essential in the prevention and treatment of cardiovascular diseases prevention and treatment.

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Section: Resultsmentioning

confidence: 99%

Polyunsaturated Fatty Acids and Their Potential Therapeutic Role in Cardiovascular System Disorders—A Review

et al. 2018

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“…The latest study setup by Wang et al demonstrated that dietary ALA-rich flaxseed oil prevented alcoholic hepatic steatosis via ameliorating lipid homeostasis at the adipose tissue-liver axis in mice [ 26 ]. Meanwhile, it has been well established that increased consumption of ALA was associated with improvements in the level of TG and gene expression involved in fatty acid metabolism [ 27 , 28 ]. Consistent with previous research, in this work, we found that intervention of flaxseed oil decreased TG and TC in serum and liver, which indicated that supplement of flaxseed oil offered a strategy for optimizing lipid levels.…”

Section: Discussionmentioning

confidence: 99%

Dietary Flaxseed Oil Prevents Western-Type Diet-Induced Nonalcoholic Fatty Liver Disease in Apolipoprotein-E Knockout Mice

Han

Qiu

Zhao

et al. 2017

Oxidative Medicine and Cellular Longevity

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The prevalence of nonalcoholic fatty liver disease (NAFLD) has dramatically increased globally during recent decades. Intake of n-3 polyunsaturated fatty acids (PUFAs), mainly eicosapentaenoic acid (EPA, C20:5n-3) and docosahexaenoic acid (DHA, C22:6n-3), is believed to be beneficial to the development of NAFLD. However, little information is available with regard to the effect of flaxseed oil rich in α-linolenic acid (ALA, C18:3n-3), a plant-derived n-3 PUFA, in improving NAFLD. This study was to gain the effect of flaxseed oil on NAFLD and further investigate the underlying mechanisms. Apolipoprotein-E knockout (apoE-KO) mice were given a normal chow diet, a western-type high-fat and high-cholesterol diet (WTD), or a WTD diet containing 10% flaxseed oil (WTD + FO) for 12 weeks. Our data showed that consumption of flaxseed oil significantly improved WTD-induced NAFLD, as well as ameliorated impaired lipid homeostasis, attenuated oxidative stress, and inhibited inflammation. These data were associated with the modification effects on expression levels of genes involved in de novo fat synthesis (SREBP-1c, ACC), triacylglycerol catabolism (PPARα, CPT1A, and ACOX1), inflammation (NF-κB, IL-6, TNF-α, and MCP-1), and oxidative stress (ROS, MDA, GSH, and SOD).

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“…The treatment resulted in proliferation of endothelial cells and new vascular channel formation in the liver and between the cardiac muscle fibers. A study evaluating the effects of flaxseed oil demonstrated its efficacy in ameliorating atherosclerosis, optimizing overall lipid levels, and decreasing oxidative stress and inflammation [56]. A study in mice showed that fresh flaxseed oil can suppress hypercholesterolemic atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Improvement in serum lipids and liver morphology after supplementation of the diet with fish oil is more evident under regular feeding conditions than under high-fat or mixed diets in rats

Godea¹,

Ciubotariu²,

Danciu³

et al. 2020

Lipids Health Dis

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Background: Dietary n − 3 polyunsaturated fatty acids (PUFAs) have a role in preventing cardiovascular and hepatic diseases. However, their effects might differ significantly depending on individual dietary patterns. The aim of the present study was to evaluate the effects of dietary supplementation with ω-3 fatty acids (FA), administered in different schedules, on hepatic and aortic histological structure, lipid profile, and body weight (BW) in male Wistar rats under standard (SD), high-fat diet (HFD) and mixed feeding conditions. Methods: PUFA treatment consisted of the administration of 50 mg/kg fish oil (FO) daily by oral gavage. HFD was obtained by adding a suspension of 4% cholesterol, thiouracil and cholic acid to the animals' drinking water. The rats were maintained on the diets for 6 weeks, and different schedules of PUFA administration were used. At 14, 28, and 42 days, the morphology of liver and aortic samples and the levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), and triglycerides (TG) were assessed.

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Flaxseed Oil Containingα-Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice

Cited by 32 publications

References 56 publications

Polyunsaturated Fatty Acids and Their Potential Therapeutic Role in Cardiovascular System Disorders—A Review

Polyunsaturated Fatty Acids and Their Potential Therapeutic Role in Cardiovascular System Disorders—A Review

Dietary Flaxseed Oil Prevents Western-Type Diet-Induced Nonalcoholic Fatty Liver Disease in Apolipoprotein-E Knockout Mice

Improvement in serum lipids and liver morphology after supplementation of the diet with fish oil is more evident under regular feeding conditions than under high-fat or mixed diets in rats

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