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The research used the seeds of long flax of the "Vruchy" variety and oil-curly flax of the "Original" variety. To extract mucus, whole flax seeds were hydrated for 3 hours. in tap water, at a ratio of 1:20 and a temperature of 18 – 20 °C with constant stirring with a magnetic stirrer. This study aimed to evaluate the effect of temperature and duration of extraction on the yield of mucilaginous polysaccharides in aqueous solution from flaxseed. Change range: the temperature is selected in the range from 0 °С to 100 °С with a step of 20 °С; with a duration, ranging from 10 min to 140 min in 10 min increments. The yield of polysaccharides from flax seeds was determined for each combination of controlled factors. It was established that in the first 10 – 20 min. there is an increase in the yield of polysaccharides and the rate slows over time. For 90 min. equilibrium occurs at a temperature of 80 °C. This period of the process is optimal for the extraction of mucilage-forming polysaccharides from flaxseed. The mass of the extracted polysaccharides, from the mass of the seeds after a time of 95 min was 5.74%, and 6.00% at a temperature of 80 °С. A package of applied statistical programs was employed during the research to process the experimental data. A mathematical model of the process of extracting mucus-forming polysaccharides in an aqueous solution of flax seeds was built using regression analysis methods. The obtained regression equations determined the optimal regimes of the sought values in terms of temperature (80 – 85 °C), time (85 – 90 min) and conducted in compliance with the prescribed amount of water of 200 cm3. Within 10 – 20 min the formation of a transparent gel capsule around the flax with a phase separation boundary under seed contact with water, which does not change further. This indicates the completion of the hydration process.
The research used the seeds of long flax of the "Vruchy" variety and oil-curly flax of the "Original" variety. To extract mucus, whole flax seeds were hydrated for 3 hours. in tap water, at a ratio of 1:20 and a temperature of 18 – 20 °C with constant stirring with a magnetic stirrer. This study aimed to evaluate the effect of temperature and duration of extraction on the yield of mucilaginous polysaccharides in aqueous solution from flaxseed. Change range: the temperature is selected in the range from 0 °С to 100 °С with a step of 20 °С; with a duration, ranging from 10 min to 140 min in 10 min increments. The yield of polysaccharides from flax seeds was determined for each combination of controlled factors. It was established that in the first 10 – 20 min. there is an increase in the yield of polysaccharides and the rate slows over time. For 90 min. equilibrium occurs at a temperature of 80 °C. This period of the process is optimal for the extraction of mucilage-forming polysaccharides from flaxseed. The mass of the extracted polysaccharides, from the mass of the seeds after a time of 95 min was 5.74%, and 6.00% at a temperature of 80 °С. A package of applied statistical programs was employed during the research to process the experimental data. A mathematical model of the process of extracting mucus-forming polysaccharides in an aqueous solution of flax seeds was built using regression analysis methods. The obtained regression equations determined the optimal regimes of the sought values in terms of temperature (80 – 85 °C), time (85 – 90 min) and conducted in compliance with the prescribed amount of water of 200 cm3. Within 10 – 20 min the formation of a transparent gel capsule around the flax with a phase separation boundary under seed contact with water, which does not change further. This indicates the completion of the hydration process.
Xerostomia, characterized by reduced salivary flow, leads to significant health issues that compromise oral health-related quality of life (OHRQOL). Current therapeutic approaches for xerostomia include artificial saliva and saliva stimulants, which aim to restore moisture and lubrication to oral surfaces. Natural products have been utilized in medical applications for centuries due to their bioactive compounds that exhibit a wide range of pharmacological activities. However, their efficacy in treating xerostomia remains unclear. This review aims to assess the efficacy of natural artificial saliva and natural saliva stimulants in treating xerostomia. Methods, the data synthesis followed a rapid review protocol by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-P). Electronic databases were searched for articles published from 2004 to 2024 that evaluated the efficacy of natural artificial saliva and natural saliva stimulants for xerostomia Results obtained from PubMed and ScienceDirect databases identified 37 scientific articles, of which 7 met the inclusion criteria. This review study found that a combination of Malva sylvestris and Alcea digitata, lycopene-enriched virgin olive oil, a combination of Matricaria chamomilla and Linum usitatissimum, Althaea officinalis, and licorice improved xerostomia-related symptoms enhanced patient quality of life. Conclusion, natural compounds exhibit pharmacological activity in reducing xerostomia symptoms and improving quality of life (QoL). They show potential as constituents of artificial saliva and saliva stimulants.
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