Abstract:Detecting protein coding genes in genomic sequences is a significant challenge for understanding genome functionality, yet the reliability of bioinformatic tools for this task remains largely unverified. This is despite some of these tools having been available for several decades, and being widely used for genome and transcriptome annotation. We perform an assessment of nucleotide sequence and alignment-based de novo protein-coding detection tools. The controls we use exclude any previous training dataset and… Show more
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