New Physics contributions to ∆F = 2 transitions in the simplest extensions of the Standard Model (SM), the models with constrained Minimal Flavour Violation (CMFV), are parametrized by a single variable S(v), the value of the real box diagram function that in CMFV is bounded from below by its SM value S 0 (x t ). With already very precise experimental values of ε K , ∆M d , ∆M s and precise values of the CP-asymmetry S ψK S and ofB K entering the evaluation of ε K , the future of CMFV in the ∆F = 2 sector depends crucially on the values of |V cb |, |V ub |, γ, F Bs B Bs and F B d B B d . The ratio ξ of the latter two non-perturbative parameters, already rather precisely determined from lattice calculations, allows then together with ∆M s /∆M d and S ψK S to determine the range of the angle γ in the unitarity triangle independently of the value of S(v). Imposing in addition the constraints from |ε K | and ∆M d allows to determine the favorite CMFV values of |V cb |, |V ub |, F Bs B Bs and F B d B B d as functions of S(v) andγ. The |V cb | 4 dependence of ε K allows to determine |V cb | for a given S(v) and γ with a higher precision than it is presently possible using tree-level decays. The same applies to |V ub |, |V td | and |V ts | that are automatically determined as functions of S(v) and γ. We derive correlations between F Bs B Bs and F B d B B d , |V cb |, |V ub | and γ that should be tested in the coming years. Typically F Bs B Bs and F B d B B d have to be significantly lower than their present lattice values, while |V cb | has to be significantly higher than its tree-level determination. The region in the space of these three parameters allowed by CMFV indicates visible problems in this class of models and hints for the presence of new sources of flavour violation and/or new local operators in ∆F = 2 data that are strongly suppressed in these models. As a byproduct we propose to reduce the present uncertainty in the charm contribution to ε K by using the experimental value of ∆M K .