Motivated by a microscopic model of string-inspired foam, in which foamy structures are provided by brany point-like defects (D-particles) in space-time, we discuss flavour mixing in curved space-time for spin-0 and spin-1/2 particles. This can be view as the low energy limit of flavour non-preserving interactions of stringy matter excitations with the defects, and non-trivial space-time background induced by quantum fluctuations of the D-particles. We show, at late epochs of the Universe, that both the fermionic and the bosonic vacuum condensate behaves as a fluid with negative pressure and positive energy; however the equation of state has w fermion > −1/3 and therefore the contribution of fermion-fluid flavour vacuum alone could not yield accelerating Universes. On the other hand, for the boson fluid the equation of state is, for late eras, close to w boson → −1, and hence overall the D-foam universe appears accelerating at late eras. Flavour mixing is an interesting topic in quantum field theory, both for phenomenological (quarks, mesons, neutrinos present the mixing) and theoretical reasons: flavour mixing requires massive neutrinos, whereas in the Standard Model they are treated as massless particles. Massive neutrino mixing can thus provide a sight on the physics beyond the Standard Model.During recent years it has been suggested that the neutrino physics might play an important rôle in the understanding of the nowadays accelerated expansion of the universe [3]; in particular, it has been motivated that a mathematically correct treatment of the flavour mixing in a free theory requires the introduction of a Fock space different from the one usually considered in QFT (the irreducible representation of the Poincaré group, where the states have well defined mass). According with [4], introducing the mixing for two free Dirac spinorsà la Pontecorvo:where ψ ι (x) (with ι = e, μ) are the flavoured fields, and ψ i (x) (with i = 1, 2) are the fields with well defined mass (m 1 and m 2 , respectively), the Fock space for the flavour states can be built using the ladder operators defined byThe flavour vacuum state is therefore defined as