Flavonols and cardiovascular disease

Pérez‐Vizcaíno, Francisco; Duarte, Juan

doi:10.1016/j.mam.2010.09.002

Cited by 316 publications

(208 citation statements)

References 156 publications

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“…Their occurrence in nature and their applications have been reviewed. 1,2 Polyphenols serve a variety of roles for plants. Among others, anthocyanidins are primary red or blue pigments responsible for the coloring of plant blossoms.…”

Section: Introductionmentioning

confidence: 99%

“…6 For example, flavonols in general and especially quercetin affect multiple biochemical pathways associated with blood circulation. 2 Consequently, mounting evidence suggests that flavonols from fruit and vegetables have beneficial effects with respect to hypertension, atherosclerosis, insulin resistance (type 2 diabetes), 8 myocardic ischemia, and stroke.…”

Section: Introductionmentioning

confidence: 99%

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Structure assignment and H/D-exchange behavior of several glycosylated polyphenols

Franz¹,

Serebnitskaya²,

Gudial³

et al. 2014

Arkivoc

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The NMR-structures of six polyphenols, resveratrol (1), (-)-epicatechin (2), pelargonidin chloride (3), cyanidin chloride (4), cyanin chloride (5), and keracyanin chloride (6), were fully assigned. For the glycosylated polyphenols 5 and 6, the three-dimensional solution structure and long-range 1 H-13 C-coupling constants across the glycosidic bond were measured. Satisfactory fit to standard Karplus-equations was achieved for glycosides directly attached to the aromatic core in cyanin chloride. Molecular dynamics simulation data in vacuum at the AM1-level of theory were shown to approximate the NMR-solution data reasonably well. Selective HCl-catalyzed H/D-exchange was observed for aromatic protons H6 and H8 in flavonoid structures containing a 5,7-metadisubstituted chromelynium core with free OH-groups. The exchange took place readily in compounds 3, 4, and 6, whereas 1, 2, and 5 did not exchange.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structure assignment and H/D-exchange behavior of several glycosylated polyphenols

Franz¹,

Serebnitskaya²,

Gudial³

et al. 2014

Arkivoc

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“…Que is a member of the flavonoid family and is widely present in the plant kingdom (7). Que manifests a wide range of beneficial biological activites and can mediate cardioprotective effects (7,23). For example, an increased intake of Que has been suggested to reduce risk of cardiovascular diseases (23).…”

Section: Discussionmentioning

confidence: 99%

“…Que manifests a wide range of beneficial biological activites and can mediate cardioprotective effects (7,23). For example, an increased intake of Que has been suggested to reduce risk of cardiovascular diseases (23). Previous studies have also indicated that Que could reduce infarct size and improve functional recovery in an acute myocardial I/R model when given prior to ischemia (24,25).…”

Section: Discussionmentioning

confidence: 99%

Quercetin postconditioning attenuates myocardial ischemia/reperfusion injury in rats through the PI3K/Akt pathway

Wang

Zhang

et al. 2013

Braz J Med Biol Res

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Quercetin (Que), a plant-derived flavonoid, has multiple benefical actions on the cardiovascular system. The current study investigated whether Que postconditioning has any protective effects on myocardial ischemia/reperfusion (I/R) injury in vivo and its potential cardioprotective mechanisms. Male Sprague-Dawley rats were randomly allocated to 5 groups (20 animals/group): sham, I/R, Que postconditioning, Que+LY294002 [a phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway inhibitor], and LY294002+I/R. I/R was produced by 30-min coronary occlusion followed by 2-h reperfusion. At the end of reperfusion, myocardial infarct size and biochemical changes were compared. Apoptosis was evaluated by both TUNEL staining and measurement of activated caspase-3 immunoreactivity. The phosphorylation of Akt and protein expression of Bcl-2 and Bax were determined by Western blotting. Que postconditioning significantly reduced infarct size and serum levels of creatine kinase and lactate dehydrogenase compared with the I/R group (all P<0.05). Apoptotic cardiomyocytes and caspase-3 immunoreactivity were also suppressed in the Que postconditioning group compared with the I/R group (both P<0.05). Akt phosphorylation and Bcl-2 expression increased after Que postconditioning, but Bax expression decreased. These effects were inhibited by LY294002. The data indicate that Que postconditioning can induce cardioprotection by activating the PI3K/Akt signaling pathway and modulating the expression of Bcl-2 and Bax proteins.

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“…6 It has a wide range of pharmacological effects, such as antitumor, antiinflammation, 7 anticoagulant and dissolving thrombus. 8 In recent years, its protective effect on the liver in human body (especially patients with diabetes) attracted a wide spread attention. Researches showed that, the fisetin's liver protective effect and promoting glucose homeostasis effect were related to its antioxidant activity.…”

Section: Introductionmentioning

confidence: 99%