Flavonol and iridoid glycosides of Ajuga remota aerial parts

Manguro, Lawrence Onyango Arot; Wagai, Samuel Otieno; Lemmen, Peter

doi:10.1016/j.phytochem.2006.01.005

Cited by 19 publications

(9 citation statements)

References 21 publications

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“…The iridoids are considered chemotaxonomical markers in Ajuga species and various studies identified iridoid glycosides such as harpagide in several Ajuga plants [33,34]. Previous research demonstrated the anti-inflammatory, diuretic, antipyretic and astringent properties of some Ajuga species correlated with the presence of iridoids [12,35,36].…”

Section: Resultsmentioning

confidence: 99%

Comparative Phytochemical Profile, Antioxidant, Antimicrobial and In Vivo Anti-Inflammatory Activity of Different Extracts of Traditionally Used Romanian Ajuga genevensis L. and A. reptans L. (Lamiaceae)

et al. 2019

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Several Ajuga species are used in Romanian folk medicine for their antioxidant, antimicrobial and anti-inflammatory properties, to treat pain, fever or arthritis. Still, the active compounds responsible for these effects and their mechanism of action are scarcely known. This research was designed to investigate the phytochemical profile (e.g. iridoids, polyphenolic compounds, phytosterols), as well as the biological potential (antioxidant, antibacterial, antifungal, anti-inflammatory properties) of two selected Ajuga species collected from different regions of Romanian spontaneous flora. The main compounds identified in A. reptans aerial parts extracts were 8-O-acetylharpagide, isoquercitrin and β-sitosterol, whilst in A. genevensis were 8-O-acetylharpagide, luteolin and campesterol. The extracts were screened for their antioxidant potential using different methods (DPPH, TEAC, EPR) and the results showed a good activity, in accordance with the polyphenol content (18–26 mg GAE/g dw). The antifungal activity on the tested strains was good. The determination of few parameters linked with the inflammatory mechanism allowed the assessment of in vivo anti-inflammatory potential. Ajuga reptans and A. genevensis ethanol extracts had anti-inflammatory activity through lowering the oxidative stress, phagocytosis, PMN and total leukocytes. The best anti-oxidative and anti-inflammatory activity was observed for the Ajuga reptans 100 mg dw/mL extract when compared with diclofenac, thus the dose could be correlated with the pharmacological effect. These findings provide substantial evidence that both selected Ajuga species have the potential to be valued as sources of phytochemicals in effective anti-inflammatory herbal preparations.

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Section: Resultsmentioning

confidence: 99%

Comparative Phytochemical Profile, Antioxidant, Antimicrobial and In Vivo Anti-Inflammatory Activity of Different Extracts of Traditionally Used Romanian Ajuga genevensis L. and A. reptans L. (Lamiaceae)

et al. 2019

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“…A significant number of compounds have been isolated from various species of the Ajuga herb including; sterols (ajugalactone, β-sitosterol, γ-sitosterol, stigmasterol,), phenolic components, arabinose, cerotic acid, ecdysterone, phytoecdysteroids (phytoecdysteroid, Cyasterone, ajugalactone, ajugasterone A-C), flavonol glycosides, triterpenoid (ergosterol-5,8-endoperoxide), iridoid glycoside (8-O-acetylharpagide, 6,8-diacetylharpagide, Ajureptoside, 8-acetylherpagide, Herpagide,), neoclerodane-diterpenes and diterpenes (ajugarins I, II, IV and V) [16, 19, 28, 38, 56–58]. …”

Section: Resultsmentioning

confidence: 99%

Antidiabetic activity and phytochemical screening of extracts of the leaves of Ajuga remota Benth on alloxan-induced diabetic mice

Tafesse

Hymete

Mekonnen

et al. 2017

BMC Complement Altern Med

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Background Ajuga remota Benth is traditionally used in Ethiopia for the management of diabetes mellitus. Since this claim has not been investigated scientifically, the aim of this study was to evaluate the antidiabetic effect and phytochemical screening of the aqueous and 70% ethanol extracts on alloxan-induced diabetic mice.MethodsAfter acute toxicity test, the Swiss albino mice were induced with alloxan to get experimental diabetes animals. The fasting mean blood glucose level before and after treatment for two weeks in normal, diabetic untreated and diabetic mice treated with aqueous and 70% ethanol extracts were performed. Data were statistically evaluated by using Statistical Package for the Social Sciences software version 20. P-value <0.05 was considered statistically significant.ResultsThe medium lethal doses (LD50) of both extracts were higher than 5000 mg/kg, indicating the extracts are not toxic under the observable condition. Aqueous extracts of A.remota (300 mg/kg and 500 mg/kg body weight) reduced elevated blood glucose levels by 27.83 ± 2.96% and 38.98 ± 0.67% (P < 0.0001), respectively while the 70% ethanol extract caused a reduction of 27.94 ± 1.92% (300 mg/kg) & 28.26 ± 1.82% (500 mg/kg). Treatment with the antidiabetic drug, Glibenclamide (10 mg/kg body weight) lowered blood glucose level by 51.06% (p < 0.05). Phytochemical screening of both extracts indicated the presence of phenolic compounds, flavonoids, saponins, tannins, and steroids, which might contribute to the antidiabetic activity. The extracts, however, did not contain alkaloids and anthraquinones.ConclusionThe aqueous extract (500 mg/kg) showed the highest percentage reduction in blood glucose levels and the ability of A. remota extracts in reducing blood glucose levels presumably due to the presence of antioxidant constituents such as flavonoids. The effect of the extract supported the traditional claim of the plant.

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“…The structures of isolated compounds (Fig. 1) were elucidated using MS spectrometry, 1 H and 13 C NMR experiments and by comparision of their spectral data with that reported in the literature (Chen et al, 1996;Kuria et al, 2002;Manguro et al, 2006).…”

Section: Isolation and Characterization Of Compounds From The 70% Ethmentioning

confidence: 99%

Anti-inflammatory effect of Ajuga bracteosa Wall Ex Benth. mediated through cyclooxygenase (COX) inhibition

Gautam

Jachak

Saklani

2011

Journal of Ethnopharmacology

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Flavonol and iridoid glycosides of Ajuga remota aerial parts

Cited by 19 publications

References 21 publications

Comparative Phytochemical Profile, Antioxidant, Antimicrobial and In Vivo Anti-Inflammatory Activity of Different Extracts of Traditionally Used Romanian Ajuga genevensis L. and A. reptans L. (Lamiaceae)

Comparative Phytochemical Profile, Antioxidant, Antimicrobial and In Vivo Anti-Inflammatory Activity of Different Extracts of Traditionally Used Romanian Ajuga genevensis L. and A. reptans L. (Lamiaceae)

Antidiabetic activity and phytochemical screening of extracts of the leaves of Ajuga remota Benth on alloxan-induced diabetic mice

Anti-inflammatory effect of Ajuga bracteosa Wall Ex Benth. mediated through cyclooxygenase (COX) inhibition

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