Flavonoids target different molecules of autophagic and metastatic pathways in cancer cells

Hosseinzadeh, Aysooda; Poursoleiman, Faezeh; Biregani, Akram Naghdipour; Esmailzadeh, Ahmad

doi:10.1186/s12935-023-02960-4

Cited by 3 publications

(1 citation statement)

References 148 publications

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“…Epidemiological studies support the chemopreventive benefits of flavonoids when included in the human diet, with their intake correlated with a lower risk of developing some tumors, such as gastric, breast, prostate, and colorectal cancers [ 45 , 46 ]. Flavonoids mediate anti-neoplastic mechanisms by modulating reactive oxygen species (ROS) levels in tumor cells, inhibiting carcinogens, pro-inflammatory pathways, angiogenesis, autophagy, inducing apoptosis, and inhibiting tumor proliferation and invasion [ 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ] ( Figure 4 ).…”

Section: Antitumor Activity Of Flavonoidsmentioning

confidence: 99%

Anticancer Potential of Flavonoids: An Overview with an Emphasis on Tangeretin

de Luna,

Ferreira,

Casseb

et al. 2023

Pharmaceuticals

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Natural compounds with pharmacological activity, flavonoids have been the subject of an exponential increase in studies in the field of scientific research focused on therapeutic purposes due to their bioactive properties, such as antioxidant, anti-inflammatory, anti-aging, antibacterial, antiviral, neuroprotective, radioprotective, and antitumor activities. The biological potential of flavonoids, added to their bioavailability, cost-effectiveness, and minimal side effects, direct them as promising cytotoxic anticancer compounds in the optimization of therapies and the search for new drugs in the treatment of cancer, since some extensively antineoplastic therapeutic approaches have become less effective due to tumor resistance to drugs commonly used in chemotherapy. In this review, we emphasize the antitumor properties of tangeretin, a flavonoid found in citrus fruits that has shown activity against some hallmarks of cancer in several types of cancerous cell lines, such as antiproliferative, apoptotic, anti-inflammatory, anti-metastatic, anti-angiogenic, antioxidant, regulatory expression of tumor-suppressor genes, and epigenetic modulation.

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Section: Antitumor Activity Of Flavonoidsmentioning

confidence: 99%

Anticancer Potential of Flavonoids: An Overview with an Emphasis on Tangeretin

de Luna,

Ferreira,

Casseb

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

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A Review on Folklore Uses, Phytoconstituents and Pharmacological Activities of the Genus Berberis

Nooreen,

Rai,

Jaisal

et al. 2024

COC

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Genus berberis, an evergreen shrub of about 500 plant species found in subtropical and temperate regions but only some of them are investigated and evaluated for their phytochemistry and bioactivity. These plants are spread worldwide and help in the nourishment of humans and animals. Almost all parts of the plant are investigated for pharmacological and phytochemical purposes, including, roots, fruits, stems, buds, seeds, branches, flowers, leaves, and whole plant. Rasaut, an extract of either the stem or root of Berberis aristata is mentioned in the ancient Ayurvedic literature of India for treating indolent ulcers and eye disorders, and B. vulgaris is still used to treat malaria in North America. They have many medicinal properties and compounds that are bioactive like berberine. Berberine possesses anticancer, antimicrobial, and other activities. The plants contain a number of alkaloids, tannins, flavonoids, carotenoids, terpenoids, and other categories of chemical constituents. The alkaloidal compounds are isolated and evaluated for various activities and are found to be active. The researchers are continuously working to get novel exploration regarding the Genus Berberis . Here in the review, traditional and folkloric uses of the genus were also described. Apart from this, they possess numerous activities like anticancer, antimicrobial, antioxidant, anti-inflammatory, antidiabetic, antiulcer, antiviral and, wound healing and many more. These activities were authenticated by in-vitro and in-vivo methods. The aim of this review is to update and systematically arrange information in one platform. In this review, we extracted the current information from Pubmed, Googlescolar, Scifinder and many more databases.

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Exploring the Anticancer Properties of Sakuranin Flavanone in Human Oropharyngeal Squamous Carcinoma Cells by Studying Its Effects on Caspase-driven Apoptosis, Mitochondrial Membrane Potential (MMP) Loss, Cell Migratory and Invasiveness and m-TOR/PI3K/AKT Signalling Pathway

Kong,

Zhai,

Shi

et al. 2024

J. Oleo Sci.

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Sakuranin is a flavanone which is a class of flavonoids found abundantly in Prunus species. Flavonoids have been long known for their anticancer properties against a range of human cancers. However, there are no previous reports on the anticancer effects of sakuranin flavanone molecule. This study was designed to study the anticancer effects of sakuranin against human oropharyngeal carcinoma cells along with investigating its effects on caspase-mediated apoptosis, mitochondrial membrane potential (MMP) loss, cell migration and invasion and m-TOR/PI3K/AKT signalling pathway. MTT assay was used to study effects on cell viability. The apoptotic studies were carried out through AO/EB staining, annexin V/ FITC staining, comet assay and western blotting assay. Transwell chambers assay was used to study effects on cell migration and invasion. Flow cytometry was used to study effects of Sakuranin on mitochondrial membrane potential loss (MMP). Finally, western blotting was used to investigate m-TOR/PI3K/AKT signalling pathway. Results indicated that Sakuranin led to potent cell proliferation inhibition in a dosedependent manner. Sakuranin also induced apoptotic cell death as indicated by fluorescence microscopy and annexin V/FITC staining assays. The apoptotic induction was mediated via activation of caspase-3, caspase-9, and Bax while as it led to downregulation of Bcl-2. Sakuranin also caused inhibition of cell migration and cell invasion along with causing significant decrease in MMP. Sakuranin also caused inhibition of expressions of proteins related with m-TOR/PI3K/AKT signalling pathway. In conclusion, the current findings clearly indicate anticancer effects of Sakuranin flavanone in human oropharyngeal cancer cells and are mediated via caspase activated apoptosis, inhibition of cell migration and invasion, loss of mitochondrial membrane potential and targeting m-TOR/PI3K/AKT signalling pathway.

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Flavonoids target different molecules of autophagic and metastatic pathways in cancer cells

Cited by 3 publications

References 148 publications

Anticancer Potential of Flavonoids: An Overview with an Emphasis on Tangeretin

Anticancer Potential of Flavonoids: An Overview with an Emphasis on Tangeretin

A Review on Folklore Uses, Phytoconstituents and Pharmacological Activities of the Genus Berberis

Exploring the Anticancer Properties of Sakuranin Flavanone in Human Oropharyngeal Squamous Carcinoma Cells by Studying Its Effects on Caspase-driven Apoptosis, Mitochondrial Membrane Potential (MMP) Loss, Cell Migratory and Invasiveness and m-TOR/PI3K/AKT Signalling Pathway

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