Flavonoids Regulate Inflammation and Oxidative Stress in Cancer

Li, Guangxing; Ding, Kaiyue; Qiao, Yujie; Zhang, Liu; Zheng, Liqin; Pan, Taowen; Zhang, Lin

doi:10.3390/molecules25235628

Cited by 60 publications

(50 citation statements)

References 102 publications

(104 reference statements)

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“…Natural compounds, including flavonoids, were reported to potentially reduce inflammation in GI cancer [161,162]. The treatment of human gastric adenocarcinoma cell-line (AGS) with quercetin (10 µM) for 72 h inhibited the activation of NF-κB through the reduction of p65 phosphorylation, suggesting that quercetin can hamper NF-κB pathway activation and act as a potential anti-inflammatory agent [163].…”

Section: Inflammationmentioning

confidence: 99%

Enzymatic Metabolism of Flavonoids by Gut Microbiota and Its Impact on Gastrointestinal Cancer

Al-Ishaq

Líšková

Kubatka

et al. 2021

Cancers

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Gastrointestinal (GI) cancer is a prevalent global health disease with a massive burden on health care providers. Internal and external factors such as obesity, smoking, diet (red meat), low socioeconomic status and infection with Helicobacter pylori are the critical risk factors of GI cancers. Flavonoids are natural phenolic compounds found abundantly in fruits and vegetables. Upon ingestion, 90% of flavonoids consumed require further enzymatic metabolism by the gut microbiome to enhance their bioavailability and absorption. Several epidemiological studies reported that consumption of flavonoids and their enzymatic conversion by gut microbes is strongly associated with the reduced risk of GI cancer development. This review summarizes the current knowledge on the enzymatic conversion of flavonoids by the human gut microbiome. It also addresses the underlying anti-GI cancer effects on metabolic pathways such as apoptosis and cellular proliferation. Overall, metabolites produced from flavonoid’s enzymatic conversion illustrate anti-GI cancer effects, but the mechanisms of action need further clarification.

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Section: Inflammationmentioning

confidence: 99%

Enzymatic Metabolism of Flavonoids by Gut Microbiota and Its Impact on Gastrointestinal Cancer

Al-Ishaq

Líšková

Kubatka

et al. 2021

Cancers

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“…Natural flavonoids have gained increasing recognition in recent years for their health-related activities, such as their potential antioxidant, antitumor, and anti-inflammatory, antimicrobial, and antifungal properties [ 15 , 16 , 17 , 18 , 19 , 20 ]. Several reports describe flavonoid potential to be used as drugs and nutraceutical compounds.…”

Section: Introductionmentioning

confidence: 99%

Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids

et al. 2021

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Flavonoids are among the most abundant natural bioactive compounds produced by plants. Many different activities have been reported for these secondary metabolites against numerous cells and systems. One of the most interesting is certainly the antimicrobial, which is stimulated through various molecular mechanisms. In fact, flavonoids are effective both in directly damaging the envelope of Gram-negative and Gram-positive bacteria but also by acting toward specific molecular targets essential for the survival of these microorganisms. The purpose of this paper is to present an overview of the most interesting results obtained in the research focused on the study of the interactions between flavonoids and bacterial proteins. Despite the great structural heterogeneity of these plant metabolites, it is interesting to observe that many flavonoids affect the same cellular pathways. Furthermore, it is evident that some of these compounds interact with more than one target, producing multiple effects. Taken together, the reported data demonstrate the great potential of flavonoids in developing innovative systems, which can help address the increasingly serious problem of antibiotic resistance.

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“…Related to these or other properties, flavonoid intakes have been associated with numerous health-promoting physiological benefits for cardiovascular disease, cancer, neurological disorders, aging, obesity, etc. [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. For this reason, a wide range of human intervention studies has been developed, and the results offer promising applications in the prevention of several disorders.…”

Section: Introductionmentioning

confidence: 99%

Does Flavonoid Consumption Improve Exercise Performance? Is It Related to Changes in the Immune System and Inflammatory Biomarkers? A Systematic Review of Clinical Studies since 2005

et al. 2021

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Flavonoids are attracting increasing attention due to their antioxidant, cardioprotective, and immunomodulatory properties. Nevertheless, little is known about their role in exercise performance in association with immune function. This systematic review firstly aimed to shed light on the ergogenic potential of flavonoids. A search strategy was run using SCOPUS database. The returned studies were screened by prespecified eligibility criteria, including intervention lasting at least one week and performance objectively quantified, among others. Fifty-one studies (54 articles) met the inclusion criteria, involving 1288 human subjects, either physically untrained or trained. Secondly, we aimed to associate these studies with the immune system status. Seventeen of the selected studies (18 articles) assessed changes in the immune system. The overall percentage of studies reporting an improved exercise performance following flavonoid supplementation was 37%, the proportion being 25% when considering quercetin, 28% for flavanol-enriched extracts, and 54% for anthocyanins-enriched extracts. From the studies reporting an enhanced performance, only two, using anthocyanin supplements, focused on the immune system and found certain anti-inflammatory effects of these flavonoids. These results suggest that flavonoids, especially anthocyanins, may exert beneficial effects for athletes’ performances, although further studies are encouraged to establish the optimal dosage and to clarify their impact on immune status.

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Flavonoids Regulate Inflammation and Oxidative Stress in Cancer

Cited by 60 publications

References 102 publications

Enzymatic Metabolism of Flavonoids by Gut Microbiota and Its Impact on Gastrointestinal Cancer

Enzymatic Metabolism of Flavonoids by Gut Microbiota and Its Impact on Gastrointestinal Cancer

Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids

Does Flavonoid Consumption Improve Exercise Performance? Is It Related to Changes in the Immune System and Inflammatory Biomarkers? A Systematic Review of Clinical Studies since 2005

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