Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells

Jang, Hyon Seok; Kook, Sung Ho; Son, Young‐Ok; Kim, Jong Ghee; Jeon, Young Mi; Jang, Yong Suk; Choi, Ki Choon; Han, Seong Kyu; Lee, Kyung Yeol; Park, Byung Keon; Cho, Nam Pyo; Lee, Jeong Chae

doi:10.1016/j.bbagen.2005.08.010

Cited by 118 publications

(100 citation statements)

References 35 publications

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“…These results are in agreement with previous studies indicating that butein can suppress Bcl-2 expression (16,17). We also found that butein down-regulated the expression of cell proliferative gene products c-Myc, COX-2, and Cyclin D1, which could explain the previously reported ability of butein to suppress the proliferation of a wide variety of tumor cells, including breast carcinoma (9, 10), colon carcinoma (11,12), osteosarcoma (13), lymphoma (14,15), acute myelogenous leukemia (16), melanoma (17), and hepatic stellate (18). In this study, butein also suppressed the expression of ICAM-1, MMP-9, and VEGF, which have been linked with the invasion and metastasis of tumors.…”

Section: Discussionsupporting

confidence: 58%

“…Evidence suggests that in rodents, butein suppressed phorbol ester-induced skin tumor formation (2), abrogated carrageenan-induced rat paw edema (3), exhibited hypotensive effects (4), inhibited diabetic complications (5), reduced antibody-associated glomerulonephritis (6), suppressed liver fibrosis induced by carbon tetrachloride (7), and ameliorated renal concentrating ability in cisplatin-induced acute renal failure (8). In vitro, butein suppressed the proliferation of a wide variety of human tumor cells, including breast carcinoma (9,10), colon carcinoma (11,12), osteosarcoma (13), lymphoma (14,15), acute myelogenous leukemia (16), melanoma (17), and hepatic stellate cells (18).…”

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confidence: 99%

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Butein, a Tetrahydroxychalcone, Inhibits Nuclear Factor (NF)-κB and NF-κB-regulated Gene Expression through Direct Inhibition of IκBα Kinase β on Cysteine 179 Residue

Pandey

Sandur

Sung

et al. 2007

Journal of Biological Chemistry

178

138

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Although butein (3,4,2,4-tetrahydroxychalcone) is known to exhibit anti-inflammatory, anti-cancer, and anti-fibrogenic activities, very little is known about its mechanism of action. Because numerous effects modulated by butein can be linked to interference with the NF-B pathway, we investigated in detail the effect of this chalcone on NF-B activity. As examined by DNA binding, we found that butein suppressed tumor necrosis factor (TNF)-induced NF-B activation in a dose-and time-dependent manner; suppressed the NF-B activation induced by various inflammatory agents and carcinogens; and inhibited the NF-B reporter activity induced by TNFR1, TRADD, TRAF2, NIK, TAK1/TAB1, and IKK-␤. We also found that butein blocked the phosphorylation and degradation of IB␣ by inhibiting IB␣ kinase (IKK) activation. We found the inactivation of IKK by butein was direct and involved cysteine residue 179. This correlated with the suppression of phosphorylation and the nuclear translocation of p65. In this study, butein also inhibited the expression of the NF-B-regulated gene products involved in anti-apoptosis (IAP2, Bcl-2, and Bcl-xL), proliferation (cyclin D1 and c-Myc), and invasion (COX-2 and MMP-9). Suppression of these gene products correlated with enhancement of the apoptosis induced by TNF and chemotherapeutic agents; and inhibition of cytokine-induced cellular invasion. Overall, our results indicated that antitumor and anti-inflammatory activities previously assigned to butein may be mediated in part through the direct inhibition of IKK, leading to the suppression of the NF-B activation pathway.

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Section: Discussionsupporting

confidence: 58%

mentioning

confidence: 99%

Butein, a Tetrahydroxychalcone, Inhibits Nuclear Factor (NF)-κB and NF-κB-regulated Gene Expression through Direct Inhibition of IκBα Kinase β on Cysteine 179 Residue

Pandey

Sandur

Sung

et al. 2007

Journal of Biological Chemistry

178

138

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“…Lee et al (2005) studied that RVS glycoprotein has dose-dependent blocking activities against G/GO-induced cytotoxicity and apoptosis, increasing the glutathione peroxidase activity. Jang et al (2005) showed that RCMF (the RVS chloroformmethanol fraction) is an agent which may be capable of inducing sensitive growth inhibition and apoptosis in HOS cells.…”

Section: Discussionmentioning

confidence: 99%

Carcinostatic effect of allergen removed Rhus Verniciflua stokes based Traditional Korean Medicine on a patient with lung adenocarcinoma; single case report

Jeong¹,

Park²,

Yoon³

et al. 2008

Oriental Pharmacy and Experimental Medicine

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SUMMARYLung cancer is one of the leading causes of cancer mortality and overall treatment outcomes for lung cancer are still to be considered disappointing despite of development of new medical therapeutics on cancer. Cytostatic agents are considered as novel medication in the treatment of cancer though its benefit is most appropriately assessed through survival end points rather than the objective-response end points. We present a case of a lung adenocarcinoma patient who showed tumor lesion in patient's two different lung sites. From the day of diagnosis, the tumor lesion stayed with the almost same size with more than 1 year of Allergen-Removed Rhus Verniciflua Stokes (A-RVS) based Traditional Korean Medicine treatment without any western conventional treatment. No significant side effect was noted and the patient maintained good performance status throughout the treatment period. We assume A-RVS may have cytostatic effect on NSCLC patient and our observation justifies further investigation.

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“…61 In some cases, the anticancer effect of butein has been directly correlated with its ability to inhibit NFκB or STAT3, such as in the case of osteosarcoma, breast and hepatocellular carcinoma cells. [62][63][64][65] It is important to mention that butein has a broad mechanism of action, having the potential to target the inflammatory-promitogenic tumor pathways at several nodes upstream and downstream of NFκB/ STAT3 activation. In fact, it has been shown to inhibit ERK/ MAPK signaling.…”

Section: Butein Affects the Resistance Of Mpm Cells To Pemetrexedmentioning

confidence: 99%

Butein impairs the protumorigenic activity of malignant pleural mesothelioma cells

et al. 2012

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Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells

Cited by 118 publications

References 35 publications

Butein, a Tetrahydroxychalcone, Inhibits Nuclear Factor (NF)-κB and NF-κB-regulated Gene Expression through Direct Inhibition of IκBα Kinase β on Cysteine 179 Residue

Butein, a Tetrahydroxychalcone, Inhibits Nuclear Factor (NF)-κB and NF-κB-regulated Gene Expression through Direct Inhibition of IκBα Kinase β on Cysteine 179 Residue

Carcinostatic effect of allergen removed Rhus Verniciflua stokes based Traditional Korean Medicine on a patient with lung adenocarcinoma; single case report

Butein impairs the protumorigenic activity of malignant pleural mesothelioma cells

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