Flavonoids of Cotula cinerea

Abstract

Cotula L. (Compositae), the largest genus in the tribe Anthemideae (I), is a widespread Southern hemisphere group of about 80 species. The Anthemideae was arranged by Reitbrecht (2) into seven provisional subtribal groups and follows the original scheme of Bentham (3). Cotula and its relatives are placed in

Structural characterization of bioactive compounds in Cotula cinerea extracts by ultra‐high‐performance liquid chromatography with photodiode array and high‐resolution time‐of‐flight mass spectrometry detectors

“…Thus compound 11 showed peaks at m/z 463 and 301 corresponding to the [M − H] − ion and the subsequent loss of a hexose moiety [M − H − 162] − . This compound was thus concluded to be quercetin 3‐ O ‐glucoside as has been already described in Cotula cinerea extracts . The presence of the quercetin aglycone peak corresponding to the Y 0 − ion at m/z 301 and subsequent product ions at m/z 257, 179, and 151, consistent with the quercetin aglycone, were also observed for the compounds.…”

“…All these compounds have been previously reported, and their structures were also confirmed using the single ion monitoring acquisition mode which allowed the molecular formulae of the corresponding compounds to be obtained.…”

“…From a phytochemical point of view, Cotula cinerea was reported to contain a wide range of phytochemical compounds such as saponins, alkaloids, phenolic acids, tannins, flavonoids, steroids, and terpenoids . Although the phytochemical and the biological activities of Cotula cinerea have been reported in previous studies, the secondary metabolites of the Moroccan plant have not been thoroughly investigated and will be explored in the present work.…”

Constituents of flowers of Paeoniaceae plants, Paeonia suffruticosa and Paeonia lactiflora

“…The MeOH extracts were subjected to Diaion HP-20 column chromatography to give H 2 O-and MeOH-eluted fractions, respectively. The MeOH-eluted fraction from P. suffruticosa flowers was subjected to silica gel and ODS column chromatography and finally HPLC to furnish a new monoterpene glycoside, floralalbiflorin I (1, 0.00224%, the yield isolated from P. suffruticosa flowers), together with 21 known compounds, methyl gallate (3, 0.31%) (Ma et al, 2005), gallic acid (4, 0.0017%) (Wei et al, 2005), 1-O-(4-hydroxybenzoyl)-b-D-galactopyranoside (5, 0.00098%) (Kiso et al, 2000), 2-phenylethyl-b-D-glucopyranoside (7, 0.0037%) (Shu and Lawrence, 1994), salidroside (8, 0.00057%) , 4-hydroxyphenylethyl-b-D-galactopyranoside (9, 0.00059%) (Guo et al, 2010), 1,2,3,4,6-penta-O-galloyl-b-D-glucopyranoside (10, 0.19%) (Nishizawa et al, 1982), apigenin (11, 0.00021%) (Markham et al, 1978), apigenin 7-O-b-D-glucopyranoside (12, 0.0011%) (Redaelli et al, 1980), luteolin (13, 0.0013%) (Park et al, 2007), luteolin 7-O-b-D-glucopyranoside (14, 0.0018%) (Ahmed et al, 1987), kaempferol (15, 0.00040%) (Okuyama et al, 1978), kaempferol 3-O-b-D-glucopyranoside (16, 0.00015%) (Markham et al, 1978), kaempferol 7-O-b-D-glucopyranoside (17, 0.0019%) (Markham et al, 1978), quercetin 3-O-b-D-glucopyranoside (18, 0.00023%) (Markham et al, 1978), chalcononaringenin 4-O-b-Dglucopyranoside (25, 0.0016%) (Iwashina et al, 2005), paeoniflorin (26, 0.064%) (Lin et al, 1996), oxypaeoniflorin (27, 0.0014%) (Kaneda et al, 1972), mudanpioside I (28, 0.00037%), benzoylpaeoniflorin (29, 0.00052%) (Ding et al, 1999), and sachaloside (30, 0.00075%) (Cheng et al, 2010). The MeOH-eluted fraction from P. lactiflora flowers was also subjected to silica gel and ODS column chromatography and finally HPLC to furnish a new flavonol glycoside, lactifloraoside I (2, 0.0068%, the yield isolated from P. lactiflora flowers), together with 13 known compounds, 3 (0.038%), methylarbutin (6, 0.00071%) (Quintus et al, 2005), 10 (1.27%) (Nishizawa et al, 1982), 16 (0.0034%) (Markham et al, 1978), 18 (0.0027%) (Markham et al, 1978), kaempferol 3,7-O-b-D-diglucopyranoside (19, 0.0011%) (Markham et al, 1978), kaempherol 3-O-...…”

Phytochemical Studies on Cotula Cinerea L. At Different Habitats

“…Ahmed et al (1987) investigated the flavonoids of Cotula cinerea and found that the aerial parts of the plant contain kaempferitin, quercetrin, quercetin, kaempferol and some other flavonoid compounds.…”