Flavonoids of Atraphaxis pyrifolia. IV

Chumbalov, T. K.; Omurkamzinova, V. B.

doi:10.1007/bf00565203

Cited by 7 publications

(6 citation statements)

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“…These data demonstrated that 8 – 12 had a catechol B-ring instead of the pyrogallol moiety in 1 – 5 . The structures of 8 – 12 were reported previously, ,, and these compounds were identified as 8- O -β- d -glucopyranosyl-7- O -methyl-3- O -α- l -rhamnopyranosylgossypetin ( 8 ), 8- O -acetyl-7- O -methyl-3- O -α- l -rhamnopyranosylgossypetin ( 9 ), 7- O -methyl-3- O -α- l -rhamnopyranosylgossypetin ( 10 ), 8- O -acetyl-7- O -methylgossypetin ( 11 ), and 7- O -methylgossypetin ( 12 ).…”

Section: Resultsmentioning

confidence: 87%

“…These were europetin 3- O -α- l -rhamnopyranoside ( 6 ), myricitrin ( 7 ), fisetinidol, gallocatechin ( 14 ), catechin, afzelechin ( 15 ), aromadendrin, epigallocatechin ( 16 ), epicatechin ( 17 ), nikoenoside ( 19 ), N - trans -feruloyldopamine ( 20 ), N - trans -feruloyltyramine ( 21 ), N - p - trans -coumaroyldopamine ( 22 ), N - p - trans -coumaroyltyramine ( 23 ), emodin 8- O -β- d -glucopyranoside, emodin 8- O -(6′- O -malonyl)glucoside, , torachrysone 8- O -β- d -(6′- O -malonyl)glucopyranoside, syringaresinol, dehydroconiferyl alcohol, 3,4,5-trimethoxyphenyl 1- O -β- d -glucopyranoside, and methyl syringate . Compounds 8 – 12 had been isolated previously by Russian research groups and were identified as 8- O -β- d -glucopyranosyl-7- O -methyl-3- O -α- l -rhamnopyranosylgossypetin ( 8 ), 8- O -acetyl-7- O -methyl-3- O -α- l -rhamnopyranosylgossypetin ( 9 ), 7- O -methyl-3- O -α- l -rhamnopyranosylgossypetin ( 10 ), 8- O -acetyl-7- O -methylgossypetin ( 11 ), , and 7- O -methylgossypetin ( 12 ) . These compounds were identified using NMR data based on a comparison with the data for compounds 1 – 5 .…”

Section: Resultsmentioning

confidence: 99%

“…laetevirens and A . pyrifolia , − and other flavonoids and phenolic compounds were extracted from A . muschketovii and A .…”

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confidence: 99%

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Antioxidant Flavonols and Phenolic Compounds from Atraphaxis frutescens and Their Inhibitory Activities against Insect Phenoloxidase and Mushroom Tyrosinase

et al. 2016

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Chemical investigation of the aerial parts of Atraphaxis frutescens resulted in the isolation of five 7-methoxyflavonols with pyrogallol B-ring moieties (1-5), a fisetinidol glucoside (13), and a benzyl glycoside (18), together with 26 known compounds including flavonoids, phenylpropanoid amides, anthraquinone glycosides, lignans, and a benzyl derivative. The principal chemical structural feature of the isolated compounds was either a pyrogallol or catechol B-ring moiety, and they showed potent 1,1-diphenyl-2-picrylhydrazyl radical scavenging activities. To assess the effects of these antioxidants on biological enzymes, their inhibitory effects against an insect phenoloxidase and a mushroom tyrosinase were evaluated. This study indicated that insect phenoloxidase was inhibited by phenylpropanoid amides and that mushroom tyrosinase was inhibited by the characteristic 7-methoxyflavonol 3-O-rhamnopyranosides.

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Section: Resultsmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 99%

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Antioxidant Flavonols and Phenolic Compounds from Atraphaxis frutescens and Their Inhibitory Activities against Insect Phenoloxidase and Mushroom Tyrosinase

et al. 2016

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“…The immunomodulatory effects of phenols enhance immune responses against infections and diseases, and their use in wound healing and skin health applications is based on their ability to promote tissue repair and protect the skin from oxidative damage. The versatile pharmacological activities of phenols underscore their importance in preventive and therapeutic approaches to various health conditions [ 102 , 103 , 104 ].…”

Section: Bioactive Compounds From Four Atraphaxis ...mentioning

confidence: 99%

Exploring Four Atraphaxis Species: Traditional Medicinal Uses, Phytochemistry, and Pharmacological Activities

Abilkassymova,

Turgumbayeva,

Sarsenova

et al. 2024

Molecules

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Atraphaxis is a genus of flowering plants in the family Polygonaceae, with approximately 60 species. Species of Atraphaxis are much-branched woody plants, forming shrubs or shrubby tufts, primarily inhabiting arid zones across the temperate steppe and desert regions of Central Asia, America, and Australia. Atraphaxis species have been used by diverse groups of people all over the world for the treatment of various diseases. However, their biologically active compounds with therapeutic properties have not been investigated well. Studying the biologically active components of Atraphaxis laetevirens, Atraphaxis frutescens, Atraphaxis spinosa L., and Atraphaxis pyrifolia is crucial for several reasons. Firstly, it can unveil the therapeutic potential of these plants, aiding in the development of novel medicines or natural remedies for various health conditions. Understanding their bioactive compounds enables scientists to explore their pharmacological properties, potentially leading to the discovery of new drugs or treatments. Additionally, investigating these components contributes to preserving traditional knowledge and validating the historical uses of these plants in ethnomedicine, thus supporting their conservation and sustainable utilization. These herbs have been used as an anti-inflammatory and hypertension remedies since the dawn of time. Moreover, they have been used to treat a variety of gastrointestinal disorders and problems related to skin in traditional Kazakh medicine. Hence, the genus Atraphaxis can be considered as a potential medicinal plant source that is very rich in biologically active compounds that may exhibit great pharmacological properties, such as antioxidant, antibacterial, antiulcer, hypoglycemic, wound healing, neuroprotective, antidiabetic, and so on. This study aims to provide a collection of publications on the species of Atraphaxis, along with a critical review of the literature data. This review will constitute support for further investigations on the pharmacological activity of these medicinal plant species.

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“…Flavonoid glycosides have been found to be the major components of Atraphaxis species [ 10 ]. Few early studies on the phytochemistry of A. pyrifolia leaves reported the compounds: 7- O -methylgossypetin-3- O -α- l -rhamnopyranoside [ 11 ], 7- O -methylluteolin 4’- O - β - d -glucofuranosyl-(1→6)- d -glucopyranoside [ 12 ]; 8-acetylmethylgossypetin 3- O -α- l -rhamnopyranoside (pyrifolin), its aglycone 8-acetyl-7-methylgossypetin (pyrifolidin), and 7-methylgossipetin 3- O -α- l -rhamnopyranoside (pyrifolinin) [ 13 ]; 7-methylgossypetin 8- β - d -glucopyranoside 3- O -α- l -rhamnopyranoside and 7-methylgossipetin 8- β - d -glucopyranoside [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and Micro-Morphological Characterization of Atraphaxis pyrifolia Bunge Growing in the Republic of Kazakhstan

Abilkassymova,

Kozykeyeva,

Aldana-Mejía

et al. 2024

Molecules

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Atraphaxis pyrifolia is a native species of Central Asia, known for curing several disorders. The species has little knowledges about its chemical composition and any information about its morphological characteristics despite its importance in traditional Asian medicine. This is one of the first approaches to the phytochemical and morphological characterization of this species. Micro-morphology was performed on the stem, and leaf parts of this plant to profile the morpho-anatomical characters using brightfield, fluorescence, polarized and scanning electron microscopy. Leaves were extracted with hexane and methanol. The hexane extract was analyzed using GC-MS analysis revealing the major presence of γ-sitosterol and nonacosane. The methanolic extract was submitted to Vacuum Liquid Chromatography and Sephadex LH-20. HPTLC, HR-ESI-MS and NMR techniques were used to identify the main compounds. Four glycosylated flavonoids were isolated: 8-O-acetyl-7-O-methyl-3-O-α-l-rhamnopyranosylgossypetin (Compound 1), and 7-O-methyl-3-O-α-l-rhamnopyranosylgossypetin (Compound 3), and two other compounds reported for the first time in the literature (Compounds 2 and 4). The findings presented herein furnish pertinent information essential for the identification and authentication of this medicinal plant. Such insights are invaluable for facilitating robust quality control measures and serve as a foundational framework for subsequent endeavours in metabolic, pharmacological, and taxonomical analyses.

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Flavonoids of Atraphaxis pyrifolia. IV

Cited by 7 publications

References 0 publications

Antioxidant Flavonols and Phenolic Compounds from Atraphaxis frutescens and Their Inhibitory Activities against Insect Phenoloxidase and Mushroom Tyrosinase

Antioxidant Flavonols and Phenolic Compounds from Atraphaxis frutescens and Their Inhibitory Activities against Insect Phenoloxidase and Mushroom Tyrosinase

Exploring Four Atraphaxis Species: Traditional Medicinal Uses, Phytochemistry, and Pharmacological Activities

Phytochemical and Micro-Morphological Characterization of Atraphaxis pyrifolia Bunge Growing in the Republic of Kazakhstan

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