Flavonoids Nutraceuticals in Prevention and Treatment of Cancer: A Review

Lotha, Robert; Sivasubramanian, Arvind

doi:10.22159/ajpcr.2017.v11i1.23410

Cited by 13 publications

(15 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They are able to induce the apoptosis of cancer cells. These special foods can be used for chemoprevention or as a supportive therapy at treatment of tumor by standard anticancer chemotherapeutics [ 175 , 176 , 177 , 178 , 179 , 180 ].…”

Section: Other Functional Applications Of Human Supplementsmentioning

confidence: 99%

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

2019

View full text Add to dashboard Cite

Dietary supplements and foods for special medical purposes are special medical products classified according to the legal basis. They are regulated, for example, by the European Food Safety Authority and the U.S. Food and Drug Administration, as well as by various national regulations issued most frequently by the Ministry of Health and/or the Ministry of Agriculture of particular countries around the world. They constitute a concentrated source of vitamins, minerals, polyunsaturated fatty acids and antioxidants or other compounds with a nutritional or physiological effect contained in the food/feed, alone or in combination, intended for direct consumption in small measured amounts. As nanotechnology provides “a new dimension” accompanied with new or modified properties conferred to many current materials, it is widely used for the production of a new generation of drug formulations, and it is also used in the food industry and even in various types of nutritional supplements. These nanoformulations of supplements are being prepared especially with the purpose to improve bioavailability, protect active ingredients against degradation, or reduce side effects. This contribution comprehensively summarizes the current state of the research focused on nanoformulated human and veterinary dietary supplements, nutraceuticals, and functional foods for special medical purposes, their particular applications in various food products and drinks as well as the most important related guidelines, regulations and directives.

show abstract

Section: Other Functional Applications Of Human Supplementsmentioning

confidence: 99%

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

2019

View full text Add to dashboard Cite

show abstract

“…Research findings revealed that flavonoids had been extensively studied in-vitro and in-vivo experiments which give strong support to the anticarcinogenic activity of these compounds 25 . In the present study, two groups of organosulfur compounds and flavonoids present in garlic were subjected to docking studies to understand the binding affinity of them against lung cancer target protein (EGFR).…”

Section: Results and Discussion: Garlicmentioning

confidence: 90%

Untitled

2019

IJPSR

View full text Add to dashboard Cite

Lung cancer is one of predominant cancer which leads to death in the developed and developing countries. 80% of lung cancer cases in India are reported as Non-Small Cell Lung Cancer (NSCLC). EGFR (Epidermal growth factor receptor) that belongs to the tyrosine kinase family (RTKs) is the key paradigm of molecular targeted therapy of lung cancer. Garlic (Allium sativum) is a common Indian spice that belongs to the Allium family, is capable of allowing cancer cell death normally, the process called apoptosis. The therapeutic effect of garlic is due to the presence of its bioactive constituents, including the organosulfur compounds and flavonoids. Molecular docking studies using AutoDock provide the comprehensive binding of bioactive compounds of garlic with EGFR that may lead to its effective inhibition. The current study paves the way for understanding the binding of garlic's bioactive compounds against EGFR, and it can act as a potential lead molecule for the development of anti-cancer agents.

show abstract

“…Thus the ability of EAF to inhibit these cell lines suggests that it may have a potential use in breast and leukemic cancers. Several findings for example, have proven that phytoconstituents such as flavonoids have significant anticancer properties [50].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Anti-Proliferative Effects of an Ethyl Acetate Fraction of the Hydro-Ethanolic Extract of Synedrella Nodiflora (L) Gaertn

Amoateng

Bekoe

Amponsah

et al. 2020

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Objective: Synedrella nodiflora is traditionally used in the treatment of several ailments. Pharmacologically, this plant has anticonvulsant, sedative, anti-nociceptive and anti-proliferative effects. This study further investigated S. nodiflora for its antioxidant and in vitro inhibition of cancerous cell lines. Methods: Phytochemical assays, and the DPPH radical scavenging method were employed in preliminary screening for antioxidant activities of the crude hydro-ethanolic extract (SNE) and resulting fractions. The potent ethyl acetate fraction (EAF), was further investigated for total phenol and flavonoid contents, reducing power, lipid peroxidation potential, and cytotoxic effects on human breast cancer (MCF-7), leukemic (Jurkat), and normal liver (Chang’s liver) cell lines. Results: The extract contained phenols, flavonoids, tannins, glycosides, sterols, terpenoids, and alkaloids. It scavenged for DPPH with an IC50 of 114 µg/ml, whereas that of EAF was 8.9 µg/ml. EAF prevented peroxidation of egg lecithin at an IC50 of 24.01±0.08 µg/ml. These IC50s are four and three times lower than the reference standards. EAF produced anti-proliferative effects against MCF-7, and Jurkat cell lines with IC50s of 205.2 and 170.9 µg/ml, respectively. EAF had a high IC50 of 252.2 µg/ml against Chang’s liver cells. At 0.1 mg/ml EAF had similar total flavonoid content to SNE, but a significantly higher total phenol content. Conclusion: The ethyl acetate fraction of S. nodiflora, exhibited the most potent antioxidant activity. It inhibited the proliferation of breast and leukemic cancer cell lines, whiles having weak cytotoxic effect on normal liver cells. These can be explored for further drug development.

show abstract

Flavonoids Nutraceuticals in Prevention and Treatment of Cancer: A Review

Cited by 13 publications

References 14 publications

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

Untitled

Antioxidant and Anti-Proliferative Effects of an Ethyl Acetate Fraction of the Hydro-Ethanolic Extract of Synedrella Nodiflora (L) Gaertn

Contact Info

Product

Resources

About