Flavonoids isolated from Sinopodophylli Fructus and their bioactivities against human breast cancer cells

Wang, Qinghui; Guo, Shuai; Yang, Xueyan; Zhang, Yifan; Shang, Ming‐Ying; Shang, Yinghui; Xiao, Jin-Fen; Cai, Shao‐Qing

doi:10.1016/s1875-5364(17)30039-0

Cited by 8 publications

(7 citation statements)

References 10 publications

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“…This species exhibits effective anticancer activity. Its secondary metabolite is effective against tumors, gynecological diseases, and rheumatism [59]. In Tibetan medicine, it is used to promote blood circulation and eliminate blood stasis and to treat gynecological diseases, bruises, dermatological diseases, and antenatal pain [60].…”

Section: Important Plant Usesmentioning

confidence: 99%

Wild plants used by the Lhoba people in Douyu Village, characterized by high mountains and valleys, in southeastern Tibet, China

Chen

Yang

et al. 2021

J Ethnobiology Ethnomedicine

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Background Douyu Village, inhabited by the Lhoba people, is situated within the Eastern Himalayas, in southeastern Tibet, China. The village is located among high mountains and valleys, which feature complex terrain with cold and dry climates and distinctive vegetation types and species. The Lhoba people in this village are isolated from other groups in China. The Lhoba people have lived in this village since the 15th century and mainly depended on gathering, hunting, and swidden agriculture before the 1960s. Because they have a long history and live under extreme climatic, geographical, and ecological conditions, the Lhoba people in Douyu Village may have unique traditional knowledge about wild plants. Thus, this research aims to record the traditional botanical knowledge of the Lhoba people in Douyu. Methods An ethnobotanical study was conducted on the Lhoba people in Douyu Village in Longzi County, Tibet, China. Semi-structured interviews and group discussions with informed consent were used in the study. We interviewed 41 informants (14 key informants) between 18 and 75 years of age. All information was collected, organized, and compiled into “use reports” for quantitative analysis. The informant consensus factor (ICF) was used to determine the homogeneity of the informants’ knowledge of medicinal plants, while the cultural importance index (CI) was used to estimate the cultural importance of shared species. Results A total of 91 wild species (90 vascular plants and 1 fungus) belonging to 71 genera and 39 families utilized by the Lhoba people in Douyu were documented. Of these species, Pimpinella xizangense and Wikstroemia lungtzeensis are endemic to Longzi County, while Sinopodophyllum hexandrum and Paeonia ludlowii are endangered species in China. All habitats, from the field vegetation at the valley bottoms to the alpine shrubland and meadows, were used for plant collection, and the numbers of species of plants collected from the various vegetation types (except for fields) decreased with increasing altitude. Our study found that 55 species are edible plants and fungi, 29 species are medicinal plants, and 38 species are used for other purposes. Medicinal plants are used for 11 categories of diseases, among which diseases of blood-forming organs (ICF = 0.96) and gastrointestinal diseases (ICF = 0.95) exhibited the highest ICF values. Based on the CI values, the most important plants in this study area are Berberis xanthophloea, B. kongboensis, Sinopodophyllum hexandrum, Vicatia thibetica, and Hippophae rhamnoides subsp. gyantsensis. Moreover, a comparison of the wild plants used by Lhoba ethnic groups in three counties in China showed significant differences among these regions. Conclusions Our study demonstrates that the wild plants utilized by the Lhoba people in Douyu Village are highly diverse, at 90 plant and one fungal species, which reflects not only the number of species but also their diversified functions. The extreme climatic, geographical, and ecological conditions of Douyu within the high mountains and valleys of the Eastern Himalayas potentially affect the Lhoba people’s culture, including plant utilization practices, and contribute to the rich diversity of the wild plants used by the local people.

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Section: Important Plant Usesmentioning

confidence: 99%

Wild plants used by the Lhoba people in Douyu Village, characterized by high mountains and valleys, in southeastern Tibet, China

Chen

Yang

et al. 2021

J Ethnobiology Ethnomedicine

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“…Breast cancer was the second most prevalent type of cancer included in the family history of cancer. In fact, several experimental studies have evaluated the effects of flavonoids present in extracts of açaí and other fruits on breast cancer cells [5,7,16,19].…”

Section: Discussionmentioning

confidence: 99%

Açaí (Euterpe oleracea Mart) Consumption and Prevention of Chronic Diseases: Is There an Association? A Preliminary Study

Silva

Rodrigues

et al. 2020

The Scientific World Journal

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Background. Flavonoids from a variety of fruits, including açaí, have beneficial antioxidant activity in several diseases, including cancer. Breast cancer is the second most prevalent cancer among Brazilian women. Studies have shown the action of flavonoids on neoplastic cells, as well as on diabetes and neurodegenerative and cardiovascular diseases. Objective. To analyze the relationship between the consumption of açaí and the presence of chronic diseases in women residing in the rural area of São Luís, Maranhão. Methods. A convenience sample of 150 women residing in the Maracanã neighborhood in São Luís, Maranhão, was used; the collected data included sociodemographic characteristics, habits, sexual and reproductive history, consumption of açaí, and history of cancer and other chronic diseases. The sample was divided into women who consumed açaí at least once a week (cases) and women who did not consume açaí (controls). Statistical analysis was performed to assess the relationships between those variables and the consumption of açaí. Results. A total of 141 women (94%) consumed açaí. Among these, 79.3% were aged between 20 and 50 years, 78.67% were farmers or housewives, 64.67% were Pardo (mixed race), 76.67% were nonsmokers, 70% were not receiving hormonal therapy, 40.67% had already undergone mammography, 28% had already undergone breast ultrasound, and 27.33% had a family history of cancer, with breast cancer being the second most prevalent cancer. There was a higher prevalence of hypertension among women who did not consume açaí than that among those who did; however, previous cancer, family history of cancer, heart disease, and diabetes were more prevalent among the consumers of açaí. There were no statistically significant relationships. Conclusion. Flavonoids are known to have a beneficial effect on some types of neoplastic cells and other diseases; therefore, larger studies are necessary to better evaluate the beneficial effects of consuming foods containing flavonoids on these diseases.

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“…(32) Prenylated flavonoids, flavonoid glycoside, and labdane diterpenes were isolated from the fruits of Sinopodophyllum hexandrum. (33,34) Prenylated biflavonoids were isolated from the roots and rhizomes of Sinopodophyllum. (35) The aporphine alkaloids, magnoflorine, corytuberine and muricinine, were found in the underground and aerial tissues of Podophyllum hexandrum.…”

Section: Podophylloideaementioning

confidence: 99%

“…Flavonoids of Sinopodophyllum have anticancer activities against human breast cancer cells. (33) S. hexundrum promotes K562 cell apoptosis possibly by inhibiting BCR/ABL-STAT5 survival signal pathways and activating the mitochondrion-associated apoptotic pathways. (131) The genus Epimedium is most commonly used in impotence (TRI 2597, β 100), followed by strengthening yang (TRI 1988, β 70), dispelling wind and dampness (TRI 1838, β 70), arthritis (TRI 1062, β 72), and neurasthenia (TRI 662, β 80).…”

Section: Berberidaceaementioning

confidence: 99%

Mining Therapeutic Efficacy from Treasure Chest of Biodiversity and Chemodiversity: Pharmacophylogeny of Ranunculales Medicinal Plants

Hao

Zheng

et al. 2022

Chin. J. Integr. Med.

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Ranunculales is an order of angiosperms, containing 7 families, i.e., Ranunculaceae (at least 50 genera, >2,000 species), Berberidaceae (17 genera, 650 species), Menispermaceae (65 genera, >350 species), Lardizabalaceae (9 genera, 50 species), Circaeasteraceae (2 species), Papaveraceae (38 genera, >700 species), and Eupteleaceae (2 species, Appendix 1). Ranunculales belongs to the basal eudicots, in which it is the most basal clade; its widely known members include poppies, barberries, monseed, akebia and buttercupss. The chemodiversity of Ranunculaceae, the fl agship family of Ranunculales, and their correlation with the biodiversity and pharmacotherapy, have been systematically reviewed by us in the context of pharmacophylogeny. (1) In recent years, the research enthusiasm for the other 4 major Ranunculales families has been growing rapidly, as plants of these families also meet human needs for food, fl avours, fragrances, and not the least, medicines during long history. Ranunculales plants form the basis of sophisticated traditional medicine systems, e.g., Chinese medicine (CM) and Ayurveda medical system. (2) These systems of medicine give rise to some important Ranunculalesbased drugs still in use today. (3,4) According to incomplete statistics, 573 Ranunculaceae and 308 Berberidaceae species were in medicinally hot nodes; (4) the therapeutic efficacy of 2 families differed substantially. For instance, up to 361 Chinese Ranunculaceae species are used against musculoskeletal diseases, followed by 321 against hepatic diseases, 242 against circulatory diseases, and 210 against skin diseases, etc.; in contrast, as many as 251 Chinese Berberidaceae species are used against eyesight diseases, followed by 249 against hepatic diseases, 242 against digestive diseases and 90 against oral diseases, etc. Nevertheless, except Ranunculaceae, the

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Flavonoids isolated from Sinopodophylli Fructus and their bioactivities against human breast cancer cells

Cited by 8 publications

References 10 publications

Wild plants used by the Lhoba people in Douyu Village, characterized by high mountains and valleys, in southeastern Tibet, China

Wild plants used by the Lhoba people in Douyu Village, characterized by high mountains and valleys, in southeastern Tibet, China

Açaí (Euterpe oleracea Mart) Consumption and Prevention of Chronic Diseases: Is There an Association? A Preliminary Study

Mining Therapeutic Efficacy from Treasure Chest of Biodiversity and Chemodiversity: Pharmacophylogeny of Ranunculales Medicinal Plants

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