Flavonoids in propolis acting on mast cell-mediated wound healing

Chirumbolo, Salvatore

doi:10.1007/s10787-012-0125-9

Cited by 14 publications

(11 citation statements)

References 27 publications

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Section: Introductionmentioning

confidence: 99%

“…Propolis, a substance produced by bees, contains numerous bioactive components, such as polyphenols [11, 13]. Therefore, along with the growing interest of naturally derived compounds, the pharmacological properties of propolis have been considered [13]. However, the advanced therapeutic use of this natural product is still limited according to its differences in chemical composition attributed to the specific botanical source and geographical region of origin, which themselves account for the different biological activities of area-distinct bee products [14, 15].…”

Section: Introductionmentioning

confidence: 99%

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Zinc and Propolis Reduces Cytotoxicity and Proliferation in Skin Fibroblast Cell Culture: Total Polyphenol Content and Antioxidant Capacity of Propolis

Tyszka-Czochara

Paśko

Reczyński

et al. 2014

Biol Trace Elem Res

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It has been demonstrated that zinc exerts its beneficial influence on skin fibroblasts. Propolis, a complex mixture of plant-derived and bees’ products, was reported to stimulate cicatrization processes in skin and prevent infections. The aim of this study was to find out how zinc and propolis influence human skin fibroblasts in cell culture and to compare the effect of individual compounds to the effect of a mixture of zinc and propolis. In this study, zinc, as zinc aspartate, at a concentration of 16 μM, increased human fibroblasts proliferation in cell culture, whereas propolis at a concentration of 0.01 % (w/v) revealed antiproliferative and cytotoxic action followed by mild cell necrosis. In culture, zinc was effectively transported into fibroblasts, and propolis inhibited the amount of zinc incorporated into the cells. An addition of propolis to the medium caused a decrease in the Zn(II) amount incorporated into fibroblasts. The obtained results also indicate an appreciable antioxidant property of propolis and revealed its potential as a supplement when applied at doses lower than 0.01 % (w/v). In conclusion, the present study showed that zinc had a protective effect on human cultured fibroblasts’ viability, although propolis revealed its antiproliferative action and caused mild necrosis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Zinc and Propolis Reduces Cytotoxicity and Proliferation in Skin Fibroblast Cell Culture: Total Polyphenol Content and Antioxidant Capacity of Propolis

Tyszka-Czochara

Paśko

Reczyński

et al. 2014

Biol Trace Elem Res

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“…Flavonoids are phenolic substances isolated from a wide range of vascular plants, with over 8000 individual compounds known [32]. They possess wide variety of activities such as antimicrobial [33], anti-oxidant [34], anti-cancer [35], anti-inflammatory [36] and wound healing [37]. Among all flavonoids there are some flavonoids such as flavan-3-ols and flavonols, possess a wide spectrum due to suppress a number of microbial virulence factors and show synergism with antibiotics [38].…”

Section: What Is the Role Of Flavonoids On Human Health?mentioning

confidence: 99%

Role of Flavonoids as Wound Healing Agent

Aslam¹,

Ahmad²,

Riaz³

et al. 2018

Phytochemicals - Source of Antioxidants and Role in Disease Prevention

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Flavonoids are found as the most abundant bioactive compounds all around the world. It is found in a number of medicinal plants that are used as wound healing agents in traditional medicinal uses such as Buddleja globosa, Moringa oleifera, Lam, Butea monosperma, Parapiptadenia rigida and Ononis spinosa. Flavonoids nowadays are being used in different formulation and wound healing dressings. Inflammation, proliferation and reepithelialization are involved in wound healing. Most of the wound healing medicinal plants possess multiple flavonoids that act as synergistic effect or combined effect. This chapter briefly reviews the role of flavonoids as wound healing agent in traditional and modern medicine.

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“…Flavonoids are the most common bioactive compounds found in medicinal plants [3]. They have several preventive activities in human disease such as antimicrobial, antioxidant, anticancer, anti-inflammatory, and wound-healing capacity [4][5][6]. Anticarcinogenic flavonoids have been reported to be found in a number of fruits and vegetables [7,8].…”

Section: Role Of Phytochemicals In Disease Prevention In Humanmentioning

confidence: 99%