Flavonoids from Woodfordia fruticosa as potential SmltD inhibitors in the alternative biosynthetic pathway of peptidoglycan

Lee, Yuan-E; Kodama, Tohru; Win, Nwet Nwet; Ki, Dae‐Won; Hoang, Nhat Nam; Wong, Chin Piow; Lae, Khine Zar Wynn; Ngwe, Hla; Dairi, Tohru; Morita, Hiroyuki

doi:10.1016/j.bmcl.2021.127787

Cited by 2 publications

(1 citation statement)

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“…Recently, Morita et al searched for inhibitors of the alternative pathway from a library of Myanmar medicinal plants and found that a 70% ethanol extract of Woodfordia fruticosa (Lythraceae) flowers inhibited the reaction of a MurD2 ortholog in Stenotrophomonas maltophilia , SmltD (Lee et al, 2021 ). This plant is used as traditional herbal medicine in East Asia and known to be rich in flavonoids and tannins (Das et al, 2007 ).…”

Section: Exploration Of Specific Inhibitorsmentioning

confidence: 99%

Discovery of an alternative pathway of peptidoglycan biosynthesis: A new target for pathway specific inhibitors

Ogasawara

Dairi

2021

Journal of Industrial Microbiology and Biotechnology

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Peptidoglycan in bacterial cell walls is a biopolymer consisting of sugars and amino acids and plays important role in maintaining cell integrity from the environment. Its biosynthesis is a major target for antibiotics and the genes and enzymes involved in the biosynthetic pathway have been well studied. However, we recently identified an alternative pathway in the early stage of peptidoglycan biosynthesis in Xanthomonas oryzae, a plant pathogen causing bacterial blight disease of rice. The distribution of the alternative pathway is limited to relatively few bacterial genera that contain many pathogenic species, including Xylella and Stenotrophomonas, besides Xanthomonas. Thus, the alternative pathway is an attractive target for the development of narrow spectrum antibiotics specific to pathogens. In this minireview, we summarize the discovery of the alternative pathway and identification of its specific inhibitors.

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Section: Exploration Of Specific Inhibitorsmentioning

confidence: 99%