Flavonoids from the roots and rhizomes of Sophora tonkinensis and their in vitro anti-SARS-CoV-2 activity

Li, Zhuo; Xie, Hang; Tang, Chunping; Lu, Feng; Ke, Chang‐Qiang; Xu, Yechun; Yao, Sheng; Yang, Ye

doi:10.1016/s1875-5364(23)60386-3

Cited by 1 publication

(3 citation statements)

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“…Sixty-six natural compounds from medicinal plants were examined for their ability to inhibit the 3CLpro [13][14][15][16][17][18][19][20][21]. Compounds with the highest IC 50 values are presented in Table 1.…”

Section: Clpro Inhibitors Studies In Vitromentioning

confidence: 99%

“…One hundred and seventy-five compounds were tested on this cell line [20,45,[53][54][55][56][57]. The most active compounds in the context of preventing the infiltration of the virus into the cell are shown in Table 4.…”

Section: Hek293t-ace2 In Vitro Studymentioning

confidence: 99%

“…The most active compounds in the context of preventing the infiltration of the virus into the cell are shown in Table 4. All information in the table was extracted from the He et al [20] study. Aloperine, a quinolizidine-type alkaloid, was first isolated from the seeds and leaves of the herbal plant, Sophora alopecuroides L. It has known for its antitumor, anti-microbial, anti-oxidative, and immune regulator effects [58].…”

Section: Hek293t-ace2 In Vitro Studymentioning

confidence: 99%

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Natural compounds from medicinal plants against COVID-19

Kolodnitsky,

Ionov,

Gravel

et al. 2023

Explor Drug Sci

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The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), known to cause the coronavirus disease 2019 (COVID-19), was declared a pandemic in early 2020. During the past time, several infections control methods have been developed. Nevertheless, all of them have certain limitations: uncertainty in duration, limited efficacy of vaccines, and lack of effective drugs for COVID-19 treatment. So, the issue of creating drugs for symptomatic and etiotropic therapy is still relevant. This review summarizes the current knowledge of using natural compounds as anti-SARS-CoV-2 agents by analysing the results of in vitro studies and completed clinical trials (CTs). Also, this work highlighted the most active molecules and discussed the possibility of using some compounds in clinical practice.

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