Flavonoids from the genus Astragalus: Phytochemistry and biological activity

Bratkov, Viktor; Shkondrov, Aleksandar; Zdraveva, Petranka; Krasteva, Ilina

doi:10.4103/0973-7847.176550

Cited by 86 publications

(32 citation statements)

References 97 publications

(77 reference statements)

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“…Flavonoids, the most common plant polyphenols, are widely distributed in every plant species and located in different plant parts, including flowers, fruits, bark, stems and leaves, as well as other parts. [ 21 22 23 24 ] They are reported to have a wide variety of biological activities, as some of them act as enzyme inhibitors and antioxidants, and others are reported to have anti-inflammatory and hepatoprotective activities. [ 25 26 27 28 ] Inflammation is a normal biological process and is the first response of the body to infections, irritations or other injuries.…”

Section: Resultsmentioning

confidence: 99%

New apigenin glycoside, polyphenolic constituents,anti-inflammatory and hepatoprotective activities of Gaillardia grandiflora and Gaillardia pulchella aerial parts

Moharram¹,

Dib²,

Marzouk³

et al. 2017

Phcog Mag

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Background:Gaillardia grandiflora Hort. ex Van Houte and Gaillardia pulchella Foug are flowering plants widely cultivated in Egypt for their ornamental value. Previous reports demonstrated that sesquiterpene derivatives represent the major compounds in both species. Moreover, only few flavones were identified from genus Gaillardia and few studies on the cytotoxicity of G. pulchella were found.Aim of the Study:Investigation of the phenolic constituents of the aerial parts of both species and evaluation of their anti-inflammatory and hepatoprotective activities.Materials and Methods:The 80% aqueous methanol extracts (AME) were prepared for both plants and evaluated for their biological activities. Phytochemical investigation of both extracts resulted in isolation of twelve compounds, which have been identified on the basis of ultraviolet, 1D and 2D nuclear magnetic resonance spectroscopy and negative ESI-MS.Results:The new 8-hydroxyapigenin 6-O-β-D-apiofuranosyl-(1’’’→6’’)-C-β-D-4C1-glucopyranoside was isolated from G. grandiflora for the first time in nature, along with schaftoside, luteolin 6-C-β-D-4C1-glucopyranoside 8-methyl ether, apigenin 6-C-β-D-4C1-glucopyranoside 8-methyl ether, isoorientin, isovitexin, 6-methoxyluteolin and hispidulin, as well as vicenin-2, vitexin, luteolin and apigenin, which were isolated from G. pulchella together with 6-methoxyluteolin. Furthermore, the AME of both species were found to be nontoxic to mice and exhibited significant anti-inflammatory and hepatoprotective activities in dose dependent manner.Conclusion:Current results shed light on the phenolic constituents of G. grandiflora and G. pulchella aerial parts and the safety of the AME of both species, in addition to their significant anti-inflammatory and hepatoprotective activities. Both plant species may be promising candidates for natural anti-inflammatory and hepatoprotective drugs.SUMMARY Phytochemical investigation of Gaillardia grandiflora and Gaillardia pulchella 80% aqueous methanol extracts of the aerial parts led to the isolation of twelve compoundsThe new compound 8-hydroxyapigenin 6-O-β-D-apiofuranosyl-(1’’’’→6’’)-C-β-D-4C1-glucopyranoside was isolated from G. grandiflora for the first time in natureSchaftoside, luteolin 6-C-β-D-4C1-glucopyranoside 8-methyl ether, apigenin 6-C-β-D-4C1-glucopyranoside 8-methyl ether, isoorientin, isovitexin, 6-methoxyluteolin and hispidulin were isolated from G. grandifloraVicenin-2, vitexin, luteolin, apigenin and 6-methoxyluteolin were isolated from G. pulchellaThe extracts of both species were nontoxic to mice up to 5 g/kg body weightBoth extracts exhibited significant anti-inflammatory and hepatoprotective activities in dose dependent manner Abbreviations used: ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; AME: The 80% aqueous methanol extract of G. grandiflora or G. pulchella aerial parts; AST: Aspartate aminotransferase; br d: Broad doublet; Comp-PC: Comparative paper chromatography; d: Doublet; 2D-PC: Two-dimensional paper chromatography; DMSO-d6: Deuterated di...

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Section: Resultsmentioning

confidence: 99%

New apigenin glycoside, polyphenolic constituents,anti-inflammatory and hepatoprotective activities of Gaillardia grandiflora and Gaillardia pulchella aerial parts

Moharram¹,

Dib²,

Marzouk³

et al. 2017

Phcog Mag

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“…According to the wide spectrum of studies, flavonoids can counteract different types of oxidizing species containing superoxide anion, hydroxyl radical, or peroxy radicals (Mao et al, 2018). Besides, flavonoid fraction extracted from natural compounds displayed substantial radioprotective effect against destruction, which is stimulated by γ-irradiation in mice (Bratkov, Shkondrov, Zdraveva, & Krasteva, 2016). Intriguingly, powerful evidence from both epidemiological and laboratory studies demonstrate that dietary intake of flavonoids is able to reduce the risk of varied cancers progression, such as prostate, breast, thyroid, lung, and ovarian cancers (Ahmed, Abd El-Hafeez, Abbas, Abdelhamid, & Abdel-Aziz, 2018; Ci, Qiao, & Han, 2016;Estevez-Sarmiento et al, 2018;Goncalves, de Freitas, & Ferreira, 2017;Guo et al, 2017; X.…”

Section: Introductionmentioning

confidence: 99%

Leukemia therapy by flavonoids: Future and involved mechanisms

Saraei

Marofi

Naimi

et al. 2018

Journal Cellular Physiology

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Flavonoids are a varied family of phytonutrients (plant chemicals) usually are detected in fruits and vegetables. In this big family, there exist more than 10,000 members that is separated into six chief subtypes: isoflavonols, flavonoenes, flavones, flavonols, anthocyanins, and chalcones. The natural compounds, such as fruits, have visible positive effects in regulating of survival involved signaling pathways that performance as the regulator of cell survival, growth, and proliferation. Researchers have established that commonly consumption up flavonoids decreases incidence and development risk of certain cancers, especially leukemia. Flavonoids have been able to induce apoptosis and stimulate cell cycle arrest in cancer cells via different pathways. Similarly, they have antiangiogenesis and antimetastasis capability, which were shown in wide ranges of cancer cells, particularly, leukemia. It seems that flavonoid because of their widespread approval, evident safety and low rate of side effects, have hopeful anticarcinogenic potential for leukemia therapy. Based on the last decade reports, the most important acting mechanisms of these natural compounds in leukemia cells are stimulating of apoptosis pathways by upregulation of caspase 3, 8, 9 and poly ADP‐ribose polymerase (PARP) and proapoptotic proteins, particularly Bax activation. As well, they can induce cell cycle arrest in target cells not only via increasing of activated levels of p21 and p53 but also by inhibition of cyclins and cyclin‐dependent kinases. Furthermore, attenuation of neclear factor‐κB and signal transducer and activator of transcription 3 activation, suppression of signaling pathway and downregulation of intracellular antiapoptotic proteins are other significant antileukemic function mechanism of flavonoids. Overall, it appears that flavonoids are promising and effective compounds in the field of leukemia therapy. In this review, we tried to accumulate and revise most promising flavonoids and finally declared their major working mechanisms in leukemia cells.

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“…The nature of antidiabetic and antioxidant activity of a plant depends on the presence of phytochemicals which include flavonoids,[ 10 ] phenolic compounds,[ 11 ] tannin, and alkaloids. [ 12 ] Our phytochemical studies revealed PELA and EELA contain most of these compounds which include flavonoids, alkaloids, carbohydrate, phenolic compounds, tannins, steroids, and fixed oils.…”

Section: Discussionmentioning

confidence: 99%

In vitro antidiabetic activity of polar and nonpolar solvent extracts from Leucas Aspera (Willd.) link leaves

Annapandian¹,

Sundaram²

2017

Phcog Res

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Background:Diabetes mellitus is a chronic illness, and the management of diabetes is a global problem. Successful treatment is required to prevent complications and organ damages. Herbal medicines are having minimal adverse effects when compared to the available synthetic drugs to treat such chronic diseases and disorders.Objective:The present study was aimed to evaluate the antidiabetic and antioxidant activity of polar and nonpolar solvent extracts of Leucas aspera (Willd.) link leaves under in vitro models.Materials and Methods:The in vitro antidiabetic activity of petroleum ether (nonpolar) and ethanol (polar) extracts were evaluated in C2C12 cell lines by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (cell viability method) and glucose uptake assay. 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging method used for the evaluation of in vitro antioxidant activity.Results:Both the polar and nonpolar solvent extracts of L. aspera had shown better antioxidant activity compared to standard (IC50 = 18.96 and 19.90 μg/mL, respectively). Petroleum ether extract exhibited better cytotoxic activity in C2C12 cell line compared to ethanol extract (concentration of test drug needed to inhibit cell growth by 50% 110.75 ± 5.5 vs. 415.25 ± 8.0 μg/mL) whereas ethanol extract showed enhanced glucose uptake activity than petroleum ether extract in C2C12 cell line at same concentrations.Conclusion:From our study results, we concluded that L. aspera (Willd.) link leaves had shown better antidiabetic activity and antioxidant activity under in vitro models. Nonpolar solvent extract produced slightly better activity than polar solvent extract. This study warrants further research and experiments on animal models.SUMMARY Petroleum ether extract of Leucas aspera (PELA) exhibited slightly higher 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity compared to ethanol extract of L. aspera (EELA)PELA exhibited better cytotoxic activity in C2C12 cell line compared to EELAEELA had shown enhanced glucose uptake activity than PELA in C2C12 cell line at same concentrationsL. aspera leaf extracts have potential scavenging of DPPH radicals similar to that of ascorbic acidOverall, PELA (nonpolar) produced slightly better antidiabetic activity and antioxidant activity than EELA (polar). Abbreviations Used: DM: Diabetes mellitus, EELA: Ethanol extract of Leucas aspera, L. aspera: Leucas aspera, PELA: Petroleum ether extract of Leucas aspera.

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Flavonoids from the genus Astragalus: Phytochemistry and biological activity

Cited by 86 publications

References 97 publications

New apigenin glycoside, polyphenolic constituents,anti-inflammatory and hepatoprotective activities of Gaillardia grandiflora and Gaillardia pulchella aerial parts

New apigenin glycoside, polyphenolic constituents,anti-inflammatory and hepatoprotective activities of Gaillardia grandiflora and Gaillardia pulchella aerial parts

Leukemia therapy by flavonoids: Future and involved mechanisms

In vitro antidiabetic activity of polar and nonpolar solvent extracts from Leucas Aspera (Willd.) link leaves

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