Flavonoids from the flowers of <i>Impatiens glandulifera</i> Royle isolated by high performance countercurrent chromatography

Vieira, Mariana Neves; Winterhalter, Peter; Jerz, Gerold

doi:10.1002/pca.2606

Cited by 63 publications

(40 citation statements)

References 25 publications

(40 reference statements)

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“…Other interesting chromatographic alternatives for the analysis of flavonoid compounds include HSCCC (Du, Cai, & Xia, 2002;Gao, Ma, & Chen, 2017;Ma, Zhou, & Tong, 2017) and HPCCC (Vieira et al, 2016). HSCCC is an all-liquid chromatographic technique very suitable for preparative isolation of pure compounds (Ignat et al, 2011).…”

Section: Chromatographic Methodsmentioning

confidence: 99%

Dihydromyricetin: A review on identification and quantification methods, biological activities, chemical stability, metabolism and approaches to enhance its bioavailability

Liú

Mao

Ding

et al. 2019

Trends in Food Science & Technology

108

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Background: Dihydromyricetin (DMY) is an important plant flavonoid, which has received great attention due to its health-benefiting activities, including antioxidant, antimicrobial, anti-inflammatory, anticancer, antidiabetic and neuroprotective activities. DMY capsules have been sold in US as a nutraceutical supplement to prevent alcoholic hangovers. The major disadvantage associated with DMY is its chemical instability and poor bioavailability caused by the combined effects of its low solubility and poor membrane permeability. This limits its practical use in the food and pharmaceutical fields. Scope and approach: The present paper gives an overview of the current methods for the identification and quantification of DMY. Furthermore, recent findings regarding the main biological properties and chemical stability of DMY, the metabolism of DMY as well as different approaches to increase DMY bioavailability in both aqueous and lipid phases are discussed. Key findings and conclusions: Current trends on identification and quantification of DMY have been focused on spectral and chromatographic techniques. Many factors such as heat, pH, metal ions, could affect the chemical stability of DMY. Despite the diverse biological effects of DMY, DMY faces with the problem of poor bioavailability. Utilization of different delivery systems including solid dispersion, nanocapsule, microemuslion, cyclodextrin inclusion complexes, co-crystallization, phospholipid complexes, and chemical or enzymatic acylation has the potential to improve both the solubility and bioavailability. DMY digested in laboratory animals undergoes reduction, dehydroxylation, methylation, glucuronidation, and sulfation. Novel DMY delivery systems and basic pharmacokinetic studies of encapsulated DMY on higher animals and humans might be required in the future.

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Section: Chromatographic Methodsmentioning

confidence: 99%

Dihydromyricetin: A review on identification and quantification methods, biological activities, chemical stability, metabolism and approaches to enhance its bioavailability

Liú

Mao

Ding

et al. 2019

Trends in Food Science & Technology

108

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“…since all the chemical components appear in the first 20 min, the chromatogram only shows this period). A total of 14 chemical components were numbered and identified in ESI − or ESI + mode by generating molecular formulas and ion fragments, as well as via their retention times (RT), experimental m/z, calculated m/z, error values, reference substance comparisons and references(Nam et al, 2015;Abdulla et al, 2017;Li et al, 2019;Marengo et al, 2019;Peng, Fan, Chai, & Wu, 2005;Peng, Yang, Fan, & Wu, 2005; Total ion chromatogram of negative and positive ions in drug-containing plasma FIGURE 2 Total ion-flow chromatograms of total flavonoids total ion-flow chromatograms of total flavonoidsVieira & Winterhalter, 2016;Zhang et al, 2012). Among them are six flavonoids(scutellarin, isoorientin, isovitexin, acacetin, luteolin and apigenin), one flavonone (orotinin), five flavonols (rutin, kaempferol-3-O-β-D-galactolipin(6 → 1)α-L-rhamnoside, kaempferol-7-O-α-L-rhamnopyranoside, quercetin and kaempferol) and two phenolic acids (chlorogenic acid and caffeic acid).…”

mentioning

confidence: 99%

Analysis of plasma migration components in Patrinia villosa (Thunb.) Juss. effective parts by UPLC–Q‐TOF–MS

Han

Wang

Yang

et al. 2019

Biomedical Chromatography

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Patrinia villosa (Thunb.) Juss. (PVJ) is described as pungent, bitter and slightly cold in Chinese medicine, and is associated with the large intestine, stomach and liver meridians. The preliminary experiments of our research team proved that PVJ total flavonoids have excellent inhibitory effects on liver cancer cells. The present experiment uses the UPLC–Q‐TOF–MS technology and serum pharmacochemistry methods to analyze the chemical components in vitro and in vivo of PVJ antiliver tumors. A total of 14 chemical components were identified in the total flavonoids extract of PVJ, and it is mainly composed of flavonoids, flavonones, flavonols and phenolic acids. At the same time, seven prototypical components and seven metabolic components were detected in the drug‐containing plasma. Hydrocaffeate and scutellarein are the phase I metabolites of caffeic acid and scutellarin, respectively. Sulfated apigenin, sulfated luteolin, sulfated kaempferol and methylated kaempferol are the II phase metabolites of apigenin, luteolin, kaempferol, respectively. The experiment provides a reference for the research and development of antitumor drug candidates, and provides a basis for revealing the bioactive components of PVJ and the antitumor mechanism.

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“…Regarding the chemical composition of the floral resources of I. glandulifera , the composition of pollen and nectar has already been determined for some compounds including sugar and protein, but secondary metabolites have only been analyzed for the whole flower (Vieira et al. , Roger et al. ).…”

Section: Methodsmentioning

confidence: 99%

Bumble bee parasite prevalence but not genetic diversity impacted by the invasive plantImpatiens glandulifera

et al. 2019

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While many bee species are experiencing population declines, some host plant generalist bees remain common in Europe, partly because they seem able to shift to new resources. However, foraging on a new alternative plant, such as an invasive species, can modify diet quality and have a potentially detrimental effect on bee health. Herein, we investigated whether the spread of the invasive plant Impatiens glandulifera affects Bombus pascuorum population regarding parasite prevalence, genetic structure, and nest density in Belgium. While no difference in bumble bee genetic structure was detected between invaded and uninvaded sites, we show that I. glandulifera occurrence was significantly correlated with a decrease in the prevalence of Apicystis bombi but not the prevalence of three other parasite species (i.e., Crithidia bombi, Nosema bombi, Nosema ceranae, and Nosema sp.). Regarding our investigations, this effect was likely not due to variation in local bumble bee population fitness before I. glandulifera flowering, nor to the relative abundance of other pollinators such as Apis mellifera, but the unique chemical composition (i.e., polyphenol rich) of the pollen of I. glandulifera remained as an interesting hypothesis. Whereas B. pascuorum queens probably colonize all the potential nesting sites in an area, invaded by I. glandulifera or not, the abundance of polyphenol ampelopsin in pollen from I. glandulifera pollen might reduce local parasite prevalence. Our field study confirms that bumble bee parasite prevalence is potentially related to the particular chemical composition of collected pollen. Plant traits such as secondary metabolite occurrence could play a key role in the health and conservation of bumble bees.

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Flavonoids from the flowers of Impatiens glandulifera Royle isolated by high performance countercurrent chromatography

Cited by 63 publications

References 25 publications

Dihydromyricetin: A review on identification and quantification methods, biological activities, chemical stability, metabolism and approaches to enhance its bioavailability

Dihydromyricetin: A review on identification and quantification methods, biological activities, chemical stability, metabolism and approaches to enhance its bioavailability

Analysis of plasma migration components in Patrinia villosa (Thunb.) Juss. effective parts by UPLC–Q‐TOF–MS

Bumble bee parasite prevalence but not genetic diversity impacted by the invasive plantImpatiens glandulifera

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