Flavonoids from the Brazilian plant Croton betulaster inhibit the growth of human glioblastoma cells and induce apoptosis

Apigenin from Croton betulaster Müll restores the immune profile of microglia against glioma cells

“…Previous studies, with the use of apigenin and others flavonoids, have demonstrated the antiproliferative and apoptotic effects on glioblastoma cells (Stump et al, ) and antitumoral and immunomodulatory potential in C6 glioma cell line, in terms of cytotoxicity, inhibition of migration, and regulation of trophic factors that reduced tumor growth and migration with similar results in co‐cultures microglia/glioma cells (Coelho et al, ; da Silva et al, ). Other studies have also showed that apigenin is able to inhibit glioblastoma cell proliferation, induce its differentiation and apoptosis (Coelho et al, ; Stump et al, ), and decrease the expression of pro‐angiogenic factors like VEGF and TGFβ‐1 (Freitas et al, ) and inhibits glioblastoma stem cells (Kim, Jung, Lee, Sohng, & Jung, ). On the other hand, we have demonstrated here and in our previous studies that apigenin at the same apigenin concentration is not toxic to microglia and astrocytes (Coelho et al, ; Stump et al, ).…”

“…Flavonoids are polyphenolic compounds that have several biological properties, among which are anti-inflammatory, antioxidant, and antitumor (Ielpo et al, 2000). Their ability of flavonoids, to inhibit the proliferation of glioma cells, has been reported in many studies Maués et al, 2019;Santos et al, 2011), without toxicity in brain normal cells (Coelho et al, 2015;Das, Banik, & Ray, 2010). Also, as recently demonstrated by da flavonoids can modulate the microglia inflammatory profile that impacts on their antiglioma properties.…”

“…plant have the capacity to inhibit the production of angiogenic factors and the proliferation of tumor cells. Besides, flavonoids increase the expression of neuronal and astrocyte differentiation markers in human glioma cells (Coelho et al, ; Freitas et al, ).…”

Targeting the Cytoskeleton with Plant-Bioactive Compounds in Cancer Therapy

“…The natural product withaferin A (WFA) exhibits antitumor activity by binding to vimentin and covalently modifying its cysteine residue, which is present in the highly conserved helical coiled coil 2B domain [88]. Penduletin and casticin, lavonoids from the Brazilian plant Croton betulaster, induced changes in the patern of expression of the cytoskeletal protein vimentin and thereby inhibit the growth of human glioblastoma cells [89].…”

<i>In vitro</i> antioxidant, antibacterial and anti-tumor activities of total flavonoids from <i>Elsholtzia densa</i> Benth

“…Casticin, penduletin, and 5-hydroxy-7,4′-dimethoxyflavone isolated from Croton betulaster Müll Arg. can inhibit the growth and viability of the human glioblastoma cell line GL-15 [21]. The flavonoids from Dryopteris erythrosora have shown obvious cytotoxic effects on the lung cancer cell line A549 [22], and flavonoids from Korean Citrus aurantium L. can induced apoptosis in cell line A549 [23].…”