Flavonoids from Tephrosia aequilata

Tarus, Paul K.; Machocho, Alex K.; Langat‐Thoruwa, Caroline; Chhabra, S. C.

doi:10.1016/s0031-9422(02)00078-x

Cited by 55 publications

(38 citation statements)

References 13 publications

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“…Demethylpraecansone B 63 and praecansone B 64 showed a low activity on the mammalian stage of T. b. rhodesiense (IC 50 = 15-16 µM) and no cytotoxicity towards L6 cells, while praecansone A 65 and its Z-isomer 66 were inactive. 55 Cissampeloflavone 67 is a chalcone-flavone dimer isolated from the aerial parts of Cissampelos pareira (Menispermaceae) with a good activity on T. b. rhodesiense bloodstream forms (IC 50 = 1 µM) and a SI of 173 when compared to KB cells. 56 However, other biflavonoids such as amentoflavone 68 and podocarpusflavones A 69 and B 70 isolated from the leaves of Celaenodendron mexicanum (Euphorbiaceae) were inactive on T. b. brucei.…”

Section: 52mentioning

confidence: 99%

Natural Products Active Against African Trypanosomes: A Step Towards New Drugs

et al. 2004

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This review covers compounds with activity on African trypanosomes (mainly Trypanosoma brucei subsp., T. congolense and T. vivax) isolated from natural sources and is organized according to the structure of the metabolites (alkaloids, phenolic derivatives, quinones, terpenes and other metabolites). The literature from the mid-1980s up to June 2003 is reviewed and 89 references are cited. Sara Hoet was born in

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Section: 52mentioning

confidence: 99%

Natural Products Active Against African Trypanosomes: A Step Towards New Drugs

et al. 2004

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“…The spectral data of synthetic materials 1-4 were in agreement with those of the natural products reported in the literature. 3,5,7,8 In conclusion, concise total syntheses of naturally occurring β-hydroxypyranochalcones, purpurenone (1), its derivative 2, praecansone B (3), and pongapinone A (4) were carried out starting from 2,4-dihydroxyacetophenone (6) or 6-methoxy-2,4-dihydroxyacetophenone through benzopyran formation reactions followed by O-methylations and subsequent coupling reactions.…”

Section: Resultsmentioning

confidence: 99%

“…4 Praecansone B (3) was isolated from Tephrosia aequilata, which is well distributed in the tropical regions of the world. 5 The roots of this plant are used to treat venereal diseases and the leaves to relieve abdominal pains.…”

Section: Introductionmentioning

confidence: 99%

Concise Synthetic Approaches to Naturally Occurring β-Hydroxypyranochalcones: First Total Synthesis of Purpurenone, Its Derivative, and Praecansone B

Wang¹,

Lee

Kim³

2012

Bulletin of the Korean Chemical Society

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“…Observouse ainda a presença de compostos contendo o sistema dimetilcromeno, corroborando o descrito na literatura. [39][40][41][42] Os resultados dos extratos e substâncias de T. toxicaria nos ensaios de atividade larvicida contra o mosquito Aedes aegypti reforçam a utilização desta espécie como uma fonte de substâncias com potencial inseticida e justificam a sua utilização como defensivo agrícola, tornando-a uma alternativa ecologicamente viável para a erradicação ou controle da dengue.…”

Section: Resultsunclassified

Estudo químico e biológico de Tephrosia toxicaria Pers.

Vasconcelos¹,

Lima²,

Lemos³

et al. 2009

Quím. Nova

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Recebido em 27/3/08; aceito em 23/9/08; publicado na web em 2/2/09 CHEMICAL AND BIOLOGICAL STUDY OF THE Tephrosia toxicaria Pers. The ethanol extracts from leaves, stems, pods and roots were assayed against the 3 rd instar Aedes aegypti larvae and the highest activity was observed in the roots extracts (LC 50 47.86 ppm). This extract was submitted to partition with hexane, chloroform, ethyl acetate and methanol. The respective fractions were bioassayed and the best larvicidal activities were identified in the hexane (LC 50 23.99 ppm) and chloroform (LC 50 13.80 ppm) fractions. Antioxidant activity (DDPH method) was observed in the ethanol extract (IC 50 276 µg/mL) from roots of T. toxicaria. Fractions from this extract were also tested and the highest antioxidant activity (IC 50 89 µg/mL) was found in the methanol fraction. The flavonoids iso-obovatin (1), obovatin (2), 6a,12a-dehydro-β-toxicarol (3), 6a,12a-dehydro-α-toxicarol (4) and α-toxicarol (5) were isolated and bioassayed against A. aegypti. The flavonoid 5 showed the best larvicidal activity (LC 50 24.55 ppm). The antioxidant activity of 2 was investigated and showed IC 50 3.370 µg/mL. The antioxidant and larvicidal activities of Tephrosia toxicaria are reported for the first time.Keywords: Tephrosia toxicaria; flavonoids; biological activity. iNtRoduÇÃoO gênero Tephrosia, família Leguminoseae Papilionoideae (Fabaceae), possui aproximadamente trezentas espécies, distribuídas em regiões tropicais e subtropicais.1 Espécies deste gênero apresentam capacidade biogenética para produzir substâncias com grande diversidade estrutural, tais como esteróides, aminoácidos e flavonóides, incluindo os isoflavonóides rotenóides.2 Estes últimos são conhecidos por apresentarem as atividades ictiotóxica 3 e larvicida. 4 Outras atividades biológicas importantes, como anti-tumoral e antiviral, aparecem também descritas na literatura. 5,6Tephrosia toxicaria Pers., popularmente conhecida por "timbó de caiena" ou "anil", é utilizada para capturar peixes 7 e o extrato aquoso de suas raízes é aplicado como defensivo agrícola em hortas orgânicas na localidade de Guaraciaba do Norte -CE. A literatura relata o isolamento e atividade anticâncer de compostos isolados de T. toxicaria, 8,9 bem como a composição química e atividade larvicida de seu óleo essencial. 10A busca por substitutos para os inseticidas sintéticos tem produzido muitos trabalhos científicos, contemplando inclusive a utilização de extratos ou constituintes ativos provenientes de plantas.10-15 Esta procura pode ser justificada pela fácil degradação destes constituintes, menor toxicidade ao homem e, conseqüen-temente, representa uma alternativa mais segura para o meio ambiente.15 Estas observações, aliadas à crescente incidência da febre dengue -endêmica nas Américas, 16 sendo diagnosticados de 50 a 100 milhões de casos por ano 17 -nos estimularam adicionalmente para uma prospecção química em T. toxicaria, com o objetivo de encontrar compostos sucedâneos aos larvicidas sintéticos utilizados no combate ao Aedes aegypt...

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Flavonoids from Tephrosia aequilata

Cited by 55 publications

References 13 publications

Natural Products Active Against African Trypanosomes: A Step Towards New Drugs

Natural Products Active Against African Trypanosomes: A Step Towards New Drugs

Concise Synthetic Approaches to Naturally Occurring β-Hydroxypyranochalcones: First Total Synthesis of Purpurenone, Its Derivative, and Praecansone B

Estudo químico e biológico de Tephrosia toxicaria Pers.

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