Flavonoids from Stem Bark of Artocarpus altilis (Parkinson ex F.A.Zorn) Fosberg

Ogundele, Seun B.; Oriola, Ayodeji Oluwabunmi; Oyedeji, Opeoluwa O.; Olorunmola, Felix Oluwasola; Agbedahunsi, Joseph M.

doi:10.1007/s42250-022-00489-z

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…There is a resurgence of interest in the pharmacological efficacy of medicinal plants in the management of various human carcinomas and other pathologies, especially in the face of increasing failure and toxicity associated with the use of some anticancer agents 17 . Numerous bioactive compounds or their derivative complexes from medicinal plants have been reported for chemopreventive and anticancer activity 18 .…”

Section: Introductionmentioning

confidence: 99%

Metabolite Profiling and Cytotoxic Investigation of Senecio biafrae Oliv. and Hiern (Compositae) on Nauplii Brine Shrimps and Cancer Cell Lines

Akinola,

Oriyomi,

Ogundele

et al. 2024

Asian J. Biol. Sci

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Background and Objective: Senecio biafrae possesses various therapeutic properties including hepatoprotective and antioxidant potentials. However, there is no information regarding its cytotoxic activity. Hence, this study investigated the cytoactivities of methanolic leaf extract (MLE) and fractions of Senecio biafrae, profiled and elucidated their metabolites. Materials and Methods: Hydromethanolic extract of S. biafrae obtained by maceration was partitioned and subjected to cytotoxicity screening using brine shrimp, human cervical adenocarcinoma (HeLa) and Prostate Cancer Cell (PC-3) lines. Bioactive principles of most of the active fractions were profiled using GC-MS. The dichloromethane (DCM) fraction was purified using column and High-Performance Liquid Chromatography (HPLC) to afford compounds 1 and 2 identified by 1 H and 13 C, DEPT-90, DEPT-135, COSY, NOESY and EI-MS spectra. Results: The MLE and its fractions exhibited significant toxicity on nauplii brine shrimp, while the hexane fraction exhibited a pronounced cytoactivity on PC-3 cell line with 92.8% followed by DCM fraction. The GC-MS profiling of hexane and DCM fractions identified 17 and 6 constituents respectively, comprising saturated and unsaturated fatty acids, diterpenoidal alcohol, phytol and aromatic compounds. Hexadecanoic acid, cis, cis, cis-9, 12, 15-octadecatrienoic acid and phytol accounted for the highest constituents in both fractions. Structure elucidation confirmed compounds 1 and 2 as stigmasterol and ergosterol with cytoactivity which compared favourably with doxorubicin. Conclusion: The study revealed that S. biafrae contains cytoconstituents evidenced by proliferation inhibition of HeLa and PC-3 cell lines. The cytoactivities and bioconstituents indicate that S. biafrae has potential to be considered as a candidate for drug development that can manage cancer-related conditions. Further investigation into the specific bioactive compounds and their mechanisms of action could provide valuable insights into the therapeutic potential of S. biafrae in cancer treatment.

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Section: Introductionmentioning

confidence: 99%

Metabolite Profiling and Cytotoxic Investigation of Senecio biafrae Oliv. and Hiern (Compositae) on Nauplii Brine Shrimps and Cancer Cell Lines

Akinola,

Oriyomi,

Ogundele

et al. 2024

Asian J. Biol. Sci

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“…& Hiern (Compositae), commonly known as life root plant, is one of the most important medicinal plants with edible leaves and stems, widely consumed as vegetables among the Yoruba tribe of South-western, Nigeria [10] . There is a resurgent of interest in the pharmacological efficacy of medicinal plants in the management of various human carcinomas and other pathologies, especially in the face of increasing failure and toxicity associated with the use of some anticancer agents [11] . Numerous bioactive compounds or their derivatised complexes from medicinal plants have been reported for chemopreventive and anticancer activity [12] .…”

Section: Introductionmentioning

confidence: 99%

Metabolite Profiling and Cytotoxic Investigation ofSenecio biafraeOliv. & Hiern (Compositae) on Nauplii Brine Shrimps and Cancer Cell Lines

Akinola,

Oriyomi,

Ogundele

et al. 2023

Preprint

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The study investigated the cytoactivities of methanolic leaf extract (MLE) and fractions of Senecio biafrae, profiled, and elucidated their metabolites. Hydromethanolic extract of S. biafrae obtained by maceration was partitioned and subjected to cytotoxicity using brine shrimp lethality assay (BSLA), human cervical adenocarcinoma (HeLa) and prostate cancer cell (PC3) lines. The bioactive principles of most active fractions were profiled using GC-MS. The dichloromethane fraction (DMF) was purified using column and high-performance liquid chromatography to afford compounds 1 and 2 identified by 1H and 13C, DEPT-90, DEPT-135, COSY, NOESY and EIMS spectra. The MLE and its fractions exhibited good toxicity on nauplii brine shrimp. The HF exhibited a pronounced cytoactivity on PC-3 cell line with 92.8% followed by DMF. The GC-MS profiling of HF and DMF identified 17 and 6 constituents respectively comprising saturated and unsaturated fatty acids, diterpenoidal alcohol, phytol and aromatic compounds. Hexadecanoic acid, cis, cis, cis-9, 12, 15-octadecatrienoic acid, and phytol accounted for the highest percentage of the constituents in both fractions. Structure elucidation confirmed compounds 1 and 2 as stigmasterol and ergosterol with cytoactivity which compared favourably with doxorubicin. The study revealed that S.biafrae contains cytotoconstituents evidenced by proliferation inhibition of HeLa and PC-3 cell lines. The cyto-activities and bioconstituents indicate that S.biafrae has the potential to be considered as a candidate for drug development in the management of cancer-related conditions. Further investigation into the specific bioactive compounds and their mechanisms of action could provide valuable insights into the therapeutic potential of S.biafrae in cancer treatment.

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Flavonoids from Stem Bark of Artocarpus altilis (Parkinson ex F.A.Zorn) Fosberg

Cited by 2 publications

References 27 publications

Metabolite Profiling and Cytotoxic Investigation of Senecio biafrae Oliv. and Hiern (Compositae) on Nauplii Brine Shrimps and Cancer Cell Lines

Metabolite Profiling and Cytotoxic Investigation of Senecio biafrae Oliv. and Hiern (Compositae) on Nauplii Brine Shrimps and Cancer Cell Lines

Metabolite Profiling and Cytotoxic Investigation ofSenecio biafraeOliv. & Hiern (Compositae) on Nauplii Brine Shrimps and Cancer Cell Lines

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