Flavonoids from Rabdosia rubescens exert anti-inflammatory and growth inhibitory effect against human leukemia HL-60 cells

Bai, Naisheng; He, Kan; Zhou, Zhu; Lai, Ching-Shu; Zhang, Li; Zheng, Quan; Shao, Xi; Pan, Min‐Hsiung; Ho, Chi‐Tang

doi:10.1016/j.foodchem.2010.03.071

Cited by 49 publications

(38 citation statements)

References 14 publications

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“…1. Their structures were confirmed by comparison of the NMR, MS, IR, and UV data with those reported previously (Andary et al, 1985;Ersöz et al, 2002;Bai et al, 2010;Lu and Foo, 2000).…”

Section: Extraction and Isolation Of Chemical Constituentssupporting

confidence: 75%

Flavonoids and phenylethanoid glycosides from Lippia nodiflora as promising antihyperuricemic agents and elucidation of their mechanism of action

Cheng

Murugaiyah

Chan

2015

Journal of Ethnopharmacology

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“…1. Their structures were confirmed by comparison of the NMR, MS, IR, and UV data with those reported previously (Andary et al, 1985;Ersöz et al, 2002;Bai et al, 2010;Lu and Foo, 2000).…”

Section: Extraction and Isolation Of Chemical Constituentssupporting

confidence: 75%

Flavonoids and phenylethanoid glycosides from Lippia nodiflora as promising antihyperuricemic agents and elucidation of their mechanism of action

Cheng

Murugaiyah

Chan

2015

Journal of Ethnopharmacology

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“…The R. rubescens contained abundant bioactive compounds such as diterpenoids, flavonoids, phenolic compounds and so on (Liu et al ., ; Tang et al ., ). These compounds showed various biological activities including anti‐inflammatory, antitumor actions, antibacterial and antioxidant activities (Hsieh et al ., ; Bai et al ., ). However, these pieces of information are still limited; little work has been reported on the antioxidant and antibacterial properties of different extracts from R. rubescens as well as action mechanism on the growth of foodborne pathogens.…”

Section: Introductionmentioning

confidence: 97%

“…Hara is an herb found in China, naturally distributed mainly in the Yellow River area, the south of Taihang Mountains as well as Wangwu Mountains in Henan Province of China. Traditionally, the whole plant of R. rubescens as a medicinal supplement has been cooked in water and widely drank to treat inflammatory and pain‐related diseases, such as stomachache, sore throat and cough, for long times (Lu et al ., ; Bai et al ., ). Therefore, some products like R. rubescens tea, tablets and the essential oil of R. rubescens have obtained more and more attentions of the consumers in China.…”

Section: Introductionmentioning

confidence: 99%

Profile of antioxidant and antibacterial activities of different solvent extracts from Rabdosia rubescens

Feng

2014

Int J of Food Sci Tech

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Summary The objective of this work was to investigate the antioxidant and antibacterial activities of different extracts from Rabdosia rubescens and to further evaluate the antibacterial mechanism of extracts. The results showed that 80% acetone extracts had the highest contents of total polyphenols (8.09 mg GAE g−1) and flavonoids (5.69 mg RE g−1) and exhibited the strongest antioxidant activities, followed by 80% methanol and 80% ethanol, and the lowest for hexane extracts. Others except for hexane extracts showed different antibacterial activities against Gram‐positive strains, while no inhibitory effects were found on tested Gram‐negative bacterial strains. Among these extracts, 80% acetone and ethanol extracts had relatively higher antibacterial activities with the lowest minimum inhibitory concentration and minimum bactericidal concentration values of 5 and 10 mg mL−1. The antibacterial mechanism of ethanol extracts against Staphylococcus aureus might be described as it disrupts cell wall, increases cell membrane permeability and then leads to the leakage of cell constituents.

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“…24 It is worth noting that compound 15 is a chlorinated derivative of nepetaefuran ( 13 ). This compound was previously obtained by reacting nepetaefolin ( 12 ) or nepetaefuran ( 13 ) with phosphorus oxychloride via an S N i addition mechanism.…”

Section: Resultsmentioning

confidence: 99%

Bis-spirolabdane Diterpenoids from Leonotis nepetaefolia

Fronczek

Ferreira

et al. 2012

J. Nat. Prod.

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Ten new bis-spirolabdane diterpenoids, leonepetaefolins A–E (1, 3, 5, 7, 9) and 15-epi-leonepetaefolins A-E (2, 4, 6, 8, 10), together with eight known labdane diterpenoids (11–18) as well as two known flavonoids apigenin and cirsiliol, were isolated from the leaves of Leonotis nepetaefolia. The structures of the new compounds were determined on the basis of 1D-and 2D-NMR experiments including 1H, 13C, DEPT, 1H-1H COSY, HSQC, HMBC, and NOESY. The absolute configuration of an epimeric mixture of 1 and 2 was determined by X-ray crystallographic analysis. The compounds isolated were evaluated for their binding propensity in several CNS G protein-coupled receptor assays in vitro.

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Flavonoids from Rabdosia rubescens exert anti-inflammatory and growth inhibitory effect against human leukemia HL-60 cells

Cited by 49 publications

References 14 publications

Flavonoids and phenylethanoid glycosides from Lippia nodiflora as promising antihyperuricemic agents and elucidation of their mechanism of action

Flavonoids and phenylethanoid glycosides from Lippia nodiflora as promising antihyperuricemic agents and elucidation of their mechanism of action

Profile of antioxidant and antibacterial activities of different solvent extracts from Rabdosia rubescens

Bis-spirolabdane Diterpenoids from Leonotis nepetaefolia

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