Flavonoids from Plinia cauliflora (Mart.) Kausel (Myrtaceae) with antifungal activity

Abstract

Plinia cauliflora is a plant species with edible fruits but its chemical composition is not totally known yet although former studies showed its potential as antifungal agent. This work aimed the chemical analysis of the leaves, the activity against fungi species and evaluated cytotoxicity. Extract was obtained with 70% ethanol. An ethyl acetate fraction was obtained and glycosylated quercetin and myricetin were isolated. Samples were tested against Candida species, dermatophytes and entomopathogenic fungi. Cytotoxicity was evaluated against fibroblast cells. Extract showed good activity against C. albicans (minimum inhibitory concentration at 156 μg/mL), C. parapsilosis (78 μg/mL), C. krusei (19 μg/mL), Trichophyton rubrum (78 μg/mL) and Microsporum canis (156 μg/mL). Isolated compounds were more active against C. krusei and T. rubrum. The extract, which was the more active sample, demonstrated low cytotoxic effect and encourage more studies against rising non-albicans species and dermatophyte T. rubrum.

Characterization of the Phytochemical Composition and Bioactivities of Anacyclus maroccanus Ball. and Anacyclus radiatus Loisel Aerial Parts: Preliminary Evidence for the Possible Development of Moroccan Plants

“…Additionally, considering the content in polyphenolic compounds of the extracts, and according to what reported in previous studies [ 41 ], we could hypothesize that these phytochemicals could influence, albeit in part, the observed bacteriostatic and mycostatic effects. Present data are also consistent with the antimicrobial properties of herbal extracts containing benzoic acid, cinnamic acid, and quercetin [ 42 , 43 , 44 , 45 ], and collectively suggest a rationale for the use of Anacyclus extracts as sources of biomolecules with antimicrobial effects.…”

Antimicrobial Activity of Silver and Gold Nanoparticles Prepared by Photoreduction Process with Leaves and Fruit Extracts of Plinia cauliflora and Punica granatum

“…The leaves of P. cauliflora present tannins and flavonoids such as ellagic acid, quercetin, and myricetin [ 76 , 77 ]. P. cauliflora fruit contains tannins, carotenoids, flavonoids such as anthocyanins and phenolics acids [ 55 , 56 , 59 ].…”

“…The results are presented in Figure 7 . Several studies demonstrated the antimicrobial activity of P. cauliflora and P. granatum extracts, possibly related to flavonoids and hydrolyzable tannins [ 77 , 80 , 81 , 82 , 83 ]. These compounds disturb cell wall integrity and membrane permeability, inhibiting protein expression and affecting microbial metabolism [ 84 ].…”

Comparative analysis of the complete chloroplast genomes from six Neotropical species of Myrteae (Myrtaceae)

“…Besides that, some studies focused on specific classes of compounds produced by Myrtaceae, such as terpenes, which present commercial uses (Guzman et al, 2014). Other studies have demonstrated the antifungal, antioxidant, antiinflammatory, gastroprotective, and other bioactivities of Myrteae species from Brazil (Salvador et al, 2011;Souza-Moreira et al, 2019). Thus, due to its plethora of roles, a growing interest has been addressed to this group as a model for evolutionary, ecological and applied studies.…”