Flavonoids from<i>Inula viscosa</i>

Grande, M.; Piera, Francisco; Cuenca, Antonio Delgado; Torres, Pascual; Bellido, I.S.

doi:10.1055/s-2007-969536

Cited by 108 publications

(72 citation statements)

References 16 publications

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“…Compounds f1-f3 ( Figure 1) were identified as verbascoside and isoverbascoside by comparing their obtained physicochemical and spectral data with published data (Cooper et al, 1980;Andary et al, 1982;Miyase et al, 1982Miyase et al, , 1991Calis et al, 1984;Grande et al, 1985;Sasaki, et al 1989;Liu et al, 1992;Hazekamp et al, 2001;Kim et al, 2001;Kanchanapoom et al, 2002). Compounds b1-b3 ( Figure 1) were identified as cornoside, decaffeoylverbascoside and icariside B 5 (Jensen et al, 1973;Aasen et al, 1974;Endo & Hikino, 1984;Miyase et al, 1988;Kuwajima et al, 1993;Hase et al, 1995;Kanchanapoom et al, 2002).…”

Section: Phytochemical Studymentioning

confidence: 87%

Chemical and biological investigation of someClerodendrumspecies cultivated in Egypt

Wahba¹,

AbouZid²,

Sleem³

et al. 2010

Pharmaceutical Biology

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Section: Phytochemical Studymentioning

confidence: 87%

Chemical and biological investigation of someClerodendrumspecies cultivated in Egypt

Wahba¹,

AbouZid²,

Sleem³

et al. 2010

Pharmaceutical Biology

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“…13,14) Some of the flavonoids were reported to either improve or inhibit insulin-stimulated glucose uptake in adipocytes. [15][16][17] For instance, sakuranetin was revealed to enhance insulin-stimulated glucose uptake in adipocytes, 15) while apigenin suppressed.…”

Section: )mentioning

confidence: 99%

“…[10][11][12] Previous investigations revealed the presence of a series of flavonoids in the whole plant including quercetin, apigenin, naringenin, sakuranetin, and aromadendrin. 13,14) Some of the flavonoids were reported to either improve or inhibit insulin-stimulated glucose uptake in adipocytes. [15][16][17] For instance, sakuranetin was revealed to enhance insulin-stimulated glucose uptake in adipocytes, 15) while apigenin suppressed.…”

mentioning

confidence: 99%

7-O-Methylaromadendrin Stimulates Glucose Uptake and Improves Insulin Resistance in Vitro

Zhang

Lee

Kim

et al. 2010

Biological & Pharmaceutical Bulletin

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The much more common condition of diabetes mellitus (DM) is type 2 DM, which represents 90 to 95% of all diagnosed cases of diabetes.1) Insulin resistance, a specific feature of type 2 DM, is the condition whereby major organs such as muscle and liver become resistant to the action of the hormone, leading to increased glucose output from the liver and reduced uptake and metabolism of glucose by other organs. 2)Studies on the molecular basis of insulin resistance have focused on the peroxisome proliferator-activated receptor g (PPARg). PPARg plays an important role in the regulation of genes involved in adipocyte differentiation, lipid storage, glucose metabolism 3) and insulin signal transduction. 4) In this regard, PPARg is a target for the treatment of insulin resistance as rosiglitazone, an anti-diabetic drug, does.Insulin binding to its receptor induces activation of a complex network of downstream molecules, including phosphatidylinositol 3-kinase (PI3K) and the serine/threonine kinase PI3K-linked protein kinase B (Akt/PKB).5,6) Activation of Akt/PKB stimulates membrane translocation of the glucose transporter, GLUT4, 7) leading to enhanced glucose uptake. Thus, Akt/PKB activation is a prerequisite for glucose uptake.Adenosine 5Ј-monophosphate-activated protein kinase (AMPK) acts as an intracellular energy sensor. Increased recruitment of the AMPK signaling system may be effective in correcting insulin resistance. 8) Activation of AMPK acutely stimulates glucose uptake via both GLUT1 and GLUT4, and enhances the long-term expression of GLUT4. 9) Thus, AMPK is responsible for mediating the stimulation of glucose uptake.The whole plant of Inula viscosa L. was traditionally used in folk medicine for treating DM.10-12) Previous investigations revealed the presence of a series of flavonoids in the whole plant including quercetin, apigenin, naringenin, sakuranetin, and aromadendrin. 13,14) Some of the flavonoids were reported to either improve or inhibit insulin-stimulated glucose uptake in adipocytes. [15][16][17] For instance, sakuranetin was revealed to enhance insulin-stimulated glucose uptake in adipocytes, 15) while apigenin suppressed. 17) Quercetin was reported with somewhat conflict in regulating insulin-stimulated glucose uptake.17,18) 7-O-Methylaromadendrin (7-O-MA) is also one of flavonoids isolated from I. viscosa. The preliminary data using our screening system indicated that 7-O-MA showed significant activities on stimulating insulininduced glucose uptake into both HepG2 cells and differentiated 3T3-L1 adipocytes. Therefore, the specific aim of this study was to investigate the ability of 7-O-MA to improve diabetic conditions and the possible molecular basis. Our results observed that 7-O-MA increased expression of PPARg2 and adipocyte-specific fatty acid binding protein The stimulation of glucose uptake into peripheral tissues is an important mechanism for the removal of glucose in blood and for the management of diabetes mellitus ( Key words 7-O-methylaromadendrin; glucose uptake; AMP-activated pr...

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“…1 H NMR and 13 C NMR spectra of compound 2 were compared with those of apigenin [5,7-dihydroxy-2-(4?-hydroxyphenyl)-4H-1-benzopyran-4-one]. 25,26) Compound 2 was identiˆed as apigenin from these spectral data and physical properties. .…”

Section: )mentioning

confidence: 99%

Antimutagenic Activity of Flavonoids fromChrysanthemum morifolium

Miyazawa

Hisama

2003

Bioscience, Biotechnology, and Biochemistry

198

113

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A methanol extract from the ‰ower heads of Chrysanthemum morifolium showed a suppressive eŠect on umu gene expression of the SOS response in Salmonella typhimurium TA1535 W pSK1002 against the mutagen 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (furylfuramide). The methanol extract was re-extracted with hexane, chloroform, ethyl acetate, butanol, and water. The ethyl acetate fraction showed a suppressive eŠect. Suppressive compounds in the ethyl acetate fraction were isolated by silica gel column chromatography and identiˆed as the ‰avonoids acacetin (1), apigenin (2), luteolin (3), and quercetin (4) by EI-MS, IR, and 1 H and 13 C NMR spectroscopy. Compounds 1-4 suppressed the furylfuramide-induced SOS response in the umu test. Compounds 1-4 suppressed 60.2, 75.7, 90.0, and 66.6z of the SOS-inducing activity at a concentration of 0.70 mmol W ml. The ID 50 (50z inhibitory dose) values of 1-4 were 0.62, 0.55, 0.44, and 0.59 mmol W ml. These compounds had the suppressive eŠects on umu gene expression of the SOS response against other mutagens, 4-nitroquinolin 1-oxide (4NQO) and N-methyl-N?-nitro-N-nitrosoguanidine (MNNG), which do not require liver-metabolizing enzymes. These compounds also showed the suppression of SOS-inducing activity against the other mutagens a‰atoxin B 1 (AfB 1 ) and 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), which require liver-metabolizing enzymes, and UV irradiation. In addition to the antimutagenic activities of these compounds against furylfuramide, Trp-P-1 and activated Trp-P-1 were also assayed by the Ames test using S. typhimurium TA100.

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Flavonoids fromInula viscosa

Cited by 108 publications

References 16 publications

Chemical and biological investigation of someClerodendrumspecies cultivated in Egypt

Chemical and biological investigation of someClerodendrumspecies cultivated in Egypt

7-O-Methylaromadendrin Stimulates Glucose Uptake and Improves Insulin Resistance in Vitro

Antimutagenic Activity of Flavonoids fromChrysanthemum morifolium

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