Flavonoids from Halostachys caspica and Their Antimicrobial and Antioxidant Activities

Abstract

Seven flavonoids have been isolated from the aerial parts of Halostachys caspica C. A. Mey. (Chenopodiaceae) for the first time. By means of physicochemical and spectrometric analysis, they were identified as luteolin (1), chrysin (2), chrysin 7-O-β-D-glucopyranoside (3), quercetin (4), quercetin 3-O-β-D-glucopyranoside (5), isorhamentin-3-O-β-D-glucopyranoside (6), and isorhamentin-3-O-β-D-rutinoside (7). All flavonoids were evaluated to show a broad antimicrobial spectrum of activity on microorganisms including seven bacterial and one fungal species as well as pronounced antioxidant activity. Among them, the aglycones with relatively low polarity had stronger bioactivity than their glycosides. The results suggested that the isolated flavonoids could be used for future development of antimicrobial and antioxidant agents, and also provided additional data for supporting the use of H. caspica as forage.

Chemical constituents of Caragana bungei shoots

“…The isolated compounds including seven flavonoids [kaempferol (3), quercetin (4) (Olennikov et al, 2011b), isorhamnetin-3-O-glucoside (9) (Manguro et al, 2004), isoquercitrin (quercetin-3-O-glucoside, 10) (Liu et al, 2010), rutin (quercetin-3-O-rutinoside, 13) , narcissin (isorhamnetin-3-O-rutinoside, 14) (Lu et al, (Boinik et al, 1983); sucrose in C. microphylla . The presence of nicotiflorin, caffeic, 3-O-caffeoylquinic, 5-Ocaffeoylquinic, 3,5-di-O-caffeoylquinic and gallic acids was firstly shown for Caragana species in this work.…”

Chemical constituents and cytotoxic activities of the extracts of Melilotus indicus

“…The structural elucidation of the isolated flavonoids was achieved through chemical and spectroscopic analysis, including HRMS, UV, 1 H, 13 C and 2D NMR, and by comparison with reported data. The isolated flavonoids were identified as catechin (1) [13,14], epicatechin (2) [15,16], taxifolin (3) [17,18], quercetin (4) [19][20][21],quercetin 3-O-β-Dglucopyranoside (5) [21][22][23], and quercetin 3-O-α-Lrhamnopyranoside (6) [21,[24][25][26], isorhamnetin 3-O-β-Dglucopyranoside (7) [21,[27][28][29] and isorhamentin 3-O-β-Drutinoside (8) [21,25,30].…”

“…Melilotus is a genus of plants including [20][21][22][23][24][25] species that are widely distributed all over the world. Melilotus indicus (M. indicus) belongs to the family Leguminosae (Fabaceae).…”

Blucher Biophysics Proceedings

“…Também apresenta atividade antioxidante (BOOTS et al, 2008;GARDI et al, 2015;RAVICHANDRAN et al, 2014) e atividade anti-inflamató ria relatada (GARDI et al, 2015). A atividade antioxidante já foi relatada dentre os demais flavonoides identificados, como a taxifolina (CHOBOT et al, 2016), isoquercetina (JIN et al, 2007;VONGSAK et al, 2015), quercetina-7-O-ramnosídeo (LIU et al, 2010), kaempferol-7-O-α-ramnosídeo (CHUA et al, 2008), quercitrina (ZHU et al, 2017), ononina (YU et al, 2005), glicitina (GENOVESE et al, 2005), sissotrina (ABDELHADY et al, 2015), amentoflavona (KIM et al, 1998;TARALLO et al, 2011), baicalina (JIN et al, 2007, isovitexina (HE et al, 2016), C-hexosil-apigenina (FERRERES et al, 2009), nobiletina (CHEN et al, 2017. Os flavonoides identificados demonstram o potencial bioativo do extrato das cascas de Hymenaea martiana.…”