Flavonoids from Cleistocalyx operculatus Buds and their Cytotoxic Activity

Synthesis, cytotoxicity evaluation and molecular docking studies on 2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethylchalcone derivatives

“…Its leaves and buds were traditionally used to treat colds, fever, inflammation, 12 gastrointestinal disorders, and for antisepsis. 11 Phytochemical investigations of S. nervosum disclosed a number of natural products, including terpenes, 13 flavanone, 14 flavone, 15 flavonol, 16 chalcone, 17 anthocyanin, 18 and phloroglucinol derivatives. 19 These derivatives have been reported to possess a wide range of anticancer and cytotoxic activities.…”

In-vitro antibacterial activity of the fractions from Cleistocalyx operculatus (Roxb.) Merr. et Perry against Staphylococcus aureus

“…This herbal also has strong protective effects on lipid peroxidation in rat. Previous phytochemical reports have characterized the phytochemical such as oleanane-type triterpenes and flavonoids isolated from C. operculatus [19]. However, C. operculatus leaves harvested in Quang Nam province have not been well-studied until now.…”

Metabolomics and molecular networking approach for exploring the anti-diabetic activity of medicinal plants

“…The reaction was performed by dissolving the enzyme and substrate in 50 mM phosphate-buffered saline (pH; 0.9% NaCl, pH 7.0). The assay was inducted by mixing 20 mL plant extracts at different concentrations and adding 80 mL PPA (1.5 units per 12 antitumor, 13 antihyperglycemic, 14 cardiotonic, 15 and anti-inammatory 16 Ficus lacor Moraceae The powdered ripe fruit is utilized as an anti-diabetic. 17 It is also used for wound healing 18 ulcers, 19 hay fever, dysentery, and stomach disorder.…”