Flavonoids from Astragalus microcephalus

Kavtaradze, N. Sh.; Alaniya, M. D.; Mshvildadze, Vakhtang; Skhirtladze, A. V.; Lavoie, Serge; Pichette, André

doi:10.1007/s10600-011-9800-0

Cited by 5 publications

(4 citation statements)

References 8 publications

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“…Separation of the EtOAc fraction by column chromatography yielded five isoliquiritigenin analogues. Known compounds were identified by comparing the spectroscopic data obtained with those reported in the corresponding literature, as isoliquiritigenin, butein, liquiritigenin, and 7,3′,4′-trihydroxyflavone …”

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confidence: 99%

Cytotoxic Evaluation against Breast Cancer Cells of Isoliquiritigenin Analogues from Spatholobus suberectus and Their Synthetic Derivatives

Meng²,

Zhou³

et al. 2015

J. Nat. Prod.

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Five isoliquiritigenin analogues, including a new methylene-bridged bischalcone (1), were isolated from Spatholobus suberectus. Cytotoxicity screening of these isolates and several synthetic derivatives indicated that the introduction, removal, position modification, or glycosylation of hydroxy groups in isoliquiritigenin did not improve the resultant cytotoxicity against the MCF-7 and MDA-MB-231 human breast cancer cell lines. In addition, cyclization of OH-2' chalcones or reduction of the α,β-unsaturated carbonyl double bond decreased such cytotoxicity substantially. However, methylation of hydroxy groups resulted in a marked increase in such cytotoxic activity. Among these active isoliquiritigenin analogues, 3',4',5',4″-tetramethoxychalcone (3h) was obtained as a compound with promising cytotoxic activity.

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confidence: 99%

Cytotoxic Evaluation against Breast Cancer Cells of Isoliquiritigenin Analogues from Spatholobus suberectus and Their Synthetic Derivatives

Meng²,

Zhou³

et al. 2015

J. Nat. Prod.

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“…As the summarized results shown in Table 1, Table 2 and Table 3 and Figure 1, Figure 2, Figure 3 and Figure 4, 46 kinds of Astragalus species have been studied for their chemical constituents in recent years [9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,…”

Section: Phytochemistrymentioning

confidence: 99%

“…Just like many other herbs, Astragalus genus plants are also a rich source of flavonoids. The flavonoids in this genus include flavonols ( 162 – 182 ) [2,8,22,63,64,65,66,67,68], flavones ( 183 – 193 ) [2,8,53,63,66,69], flavonones ( 194 – 195 ) [65,70] and isoflavonoids ( 196 – 221 ) [16,50,53,65,66,70,71,72,73,74,75], which have many kinds of bioactivities.…”

Section: Phytochemistrymentioning

confidence: 99%

A Review of Recent Research Progress on the Astragalus Genus

Li¹,

Qu²,

Dong³

et al. 2014

Molecules

238

148

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Astragalus L., is one of the largest genuses of flowering plants in the Leguminosae family. Roots of A. membranaceus Bge. var. mongholicus (Bge.) Hsiao, A. membranaceus (Fisch.) Bge. and its processed products are listed in the China Pharmacopeia for "qi deficiency" syndrome treatment. However, more and more researches on other species of Astragalus have been conducted recently. We summarize the recent researches of Astragalus species in phytochemistry and pharmacology. More than 200 constituents, including saponins and flavonoids, obtained from 46 species of Astragalus genus were collected for this article. In pharmacological studies, crude extracts of Astragalus, as well as isolated constituents showed anti-inflammatory, immunostimulant, antioxidative, anti-cancer, antidiabetic, cardioprotective, hepatoprotective, and antiviral activities. The goal of this article is to provide an overview of chemical and pharmacological studies on the Astragalus species over the last 10 years, which could be of value to new drug or food supplement research and development. OPEN ACCESS

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“…membracaceus 80,14 Calycosin 7-O-β-D-(6''-acetyl)-glucoside (91) A. membracaceus 80,14 Cajanin ( A. membranaceus 80,14 Licoagroside D (126) A. membranaceus 80,14 Vesticarpan (127) A. membranaceus 80,14 (-)-Methylinissolin (128) A. membranaceus 80,14 Miscelleneaous Sulfuretin (129) A. microcephalus 29,14 Isoliquiritigenin (130) A. membranaceus 76,14 Pendulone (131) A. membranaceus 80,14,103 International Biological Activities of the Astragalus Genus:…”

Section: (3r4r)-3-(2-hydroxy-34-dimethoxyphenyl )-Chroman-47-diol-mentioning

confidence: 99%

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2016

IJPSR

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ABSTRACT:In this review our main focus is on flavonoid groups which are one of the main active constituents found with other active constituents like saponins and polysaccharides, while poisonous groups are nitro-compounds, indolizidine alkaloids and the seleniferous derivatives in Astragalus genus. It is well established fact that flavonoid possess many biological activity such as antiallergic, anti-inflammatory, antitumor, antiviral, antioxidant anticancer including anticarcinogenic and prodifferentiative activities. Many flavonoids, including those which are phytoalexins, provide plants with a defense against viral infections. The estrogenic action of many isoflavones is well known and mixtures of flavonoids are commonly used commercially to reduce capillary fragility. Astragalus root is a very old and well known drug in traditional Chinese medicine and have been used to improve resistance to infections and to aid in immunological disorders and viral infections, and also used as hepatoprotective, heart tonic, nephritis and diabetes. This review reports all flavonoids isolated till date which is nearly about 131 from 60 species of Astragalus genus; these flavonoid are further characterized and classified into flavones, flavonols, flavanones, flavan-4-ols, isoflavones, isoflavans, petrocarpans and miscellaneous.

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Flavonoids from Astragalus microcephalus

Cited by 5 publications

References 8 publications

Cytotoxic Evaluation against Breast Cancer Cells of Isoliquiritigenin Analogues from Spatholobus suberectus and Their Synthetic Derivatives

Cytotoxic Evaluation against Breast Cancer Cells of Isoliquiritigenin Analogues from Spatholobus suberectus and Their Synthetic Derivatives

A Review of Recent Research Progress on the Astragalus Genus

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