Flavonoids: Food associations, therapeutic mechanisms, metabolism and nanoformulations

Kaushal, Niharika; Singh, Manpreet; Sangwan, Rajender Singh

doi:10.1016/j.foodres.2022.111442

Cited by 29 publications

(19 citation statements)

References 153 publications

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“…As an excellent natural product, flavonoids are beneficial to human health and have few adverse side effects. , It is important to recognize that the bioavailability of most dietary flavonoids is low, which is related to factors such as structure, glycosylation, and colonic microbial metabolism . Structural modification and novel delivery systems are common methods to improve the bioavailability and efficacy of flavonoids. − For example, phospholipon 90H complex of genistein not only improved the water solubility, dissolution rate, membrane permeation rate, and oral bioavailability of genistein but also significantly enhanced its anti-inflammatory activity .…”

Section: Future Perspectivementioning

confidence: 99%

Natural Flavonoids and Ferroptosis: Potential Therapeutic Opportunities for Human Diseases

Zhou

Zhang

2023

J. Agric. Food Chem.

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Flavonoids are a class of bioactive phytochemicals containing a core 2-phenylchromone skeleton and are widely found in fruits, vegetables, and herbs. Such natural compounds have gained significant attention due to their various health benefits. Ferroptosis is a recently discovered unique iron-dependent mode of cell death. Unlike traditional regulated cell death (RCD), ferroptosis is associated with excessive lipid peroxidation on cellular membranes. Accumulating evidence suggests that this form of RCD is involved in a variety of physiological and pathological processes. Notably, multiple flavonoids have been shown to be effective in preventing and treating diverse human diseases by regulating ferroptosis. In this review, we introduce the key molecular mechanisms of ferroptosis, including iron metabolism, lipid metabolism, and several major antioxidant systems. Additionally, we summarize the promising flavonoids targeting ferroptosis, which provides novel ideas for the management of diseases such as cancer, acute liver injury, neurodegenerative diseases, and ischemia/reperfusion (I/R) injury.

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Section: Future Perspectivementioning

confidence: 99%

Natural Flavonoids and Ferroptosis: Potential Therapeutic Opportunities for Human Diseases

Zhou

Zhang

2023

J. Agric. Food Chem.

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“…Flavonoids were shown to exert a variety of nutraceutical features such as antioxidative, anti-diabetic, anti-proliferative, anti-carcinogenic, anti-microbial and immunomodulatory abilities [44]. Due to these abilities, flavonoid supplements have been largely investigated in studies for prevention or drug efficacy evaluation in several pathologies including cancer, atherosclerosis, stroke, neuroinflammatory diseases, age-related neurodegeneration, diabetes, human herpes virus (HHV) infections and recently also COVID-19 respiratory disease [43,60,247,248] (Figure 2).…”

Section: Flavonoids As Nutraceuticals and Prebiotics For Human Healthmentioning

confidence: 99%

“…A major drawback in flavonoid medical application is linked to their poor bioavailability and low solubility in oral formulations, which makes it necessary to develop valuable delivery systems to the target cells [272]. Nanocarriers may solve this issue, by protecting encapsulated flavonoids from oxidation or degradation, and increasing their stability, solubility and bioavailability to the target tissue [44,288]. A diverse set of nano-drug delivery systems (lipidic, polymeric, micelles, nanoemulsions and nanoparticles) has been developed for naringenin encapsulation to overcome its medical application issues due to the molecule instability and low bioavailability [289,290].…”

Section: Flavonoids As Nutraceuticals and Prebiotics For Human Healthmentioning

confidence: 99%

Flavonoids Are Intra- and Inter-Kingdom Modulator Signals

et al. 2022

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Flavonoids are a broad class of secondary metabolites with multifaceted functionalities for plant homeostasis and are involved in facing both biotic and abiotic stresses to sustain plant growth and health. Furthermore, they were discovered as mediators of plant networking with the surrounding environment, showing a surprising ability to perform as signaling compounds for a multitrophic inter-kingdom level of communication that influences the plant host at the phytobiome scale. Flavonoids orchestrate plant-neighboring plant allelopathic interactions, recruit beneficial bacteria and mycorrhizal fungi, counteract pathogen outbreak, influence soil microbiome and affect plant physiology to improve its resilience to fluctuating environmental conditions. This review focuses on the diversified spectrum of flavonoid functions in plants under a variety of stresses in the modulation of plant morphogenesis in response to environmental clues, as well as their role as inter-kingdom signaling molecules with micro- and macroorganisms. Regarding the latter, the review addresses flavonoids as key phytochemicals in the human diet, considering their abundance in fruits and edible plants. Recent evidence highlights their role as nutraceuticals, probiotics and as promising new drugs for the treatment of several pathologies.

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“…Numerous studies have confirmed that flavonoids, a group of natural products with multiple phenolic structures including TFDG, are well known for their anti-inflammatory effects. 28 , 29 In addition, previous studies have found that TFDG had protective effects on CIA mice and TFDG could affect inflammatory signaling pathways, like NF-κB, JNK, and so on, to ameliorate inflammation. 27 However, NF-κB and MAPK (including P38, JNK2, and ERK) signaling pathways can be affected not only by TFDG but also by majority of flavonoids, including mangiferin, ginkgetin, puerarin and so on.…”

Section: Introductionmentioning

confidence: 99%

Theaflavin-3,3’-Digallate Ameliorates Collagen-Induced Arthritis Through Regulation of Autophagy and Macrophage Polarization

Zhang¹,

Li²,

Hou³

et al. 2023

JIR

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Purpose Previous studies have presented that theaflavin-3,3’-digallate (TFDG), one of natural flavonoids, have protective effects on collagen-induced arthritis (CIA). Besides, it was reported that TFDG could affect inflammatory signaling pathways, like NF-κB, JNK, and so on, to ameliorate inflammation. However, the anti-inflammatory mechanisms mentioned above are common to natural flavonoid products including TFDG. Therefore, this study aimed to further investigate the other mechanisms of TFDG against CIA. Methods DBA/1 mice (8–10 weeks) were intravenously injected Freund’s Adjuvant (100μL) at the base of tail and intraperitoneally injected PBS or different dosage of TFDG (1 mg/kg or 10 mg/kg). Then the paw and knee tissues were collected to assess the severity of joint destruction. In vitro experiments, bone marrow macrophages (BMMs) were exposed to TNF-α (10ng/mL) with or without different concentrations of TFDG (0.1μmol/L or 1.0μmol/L). Besides, the targets of TFDG were predicted with docking software and were verified through experiment. Results TFDG treatment could reduce M1 macrophage (pro-inflammatory) and inflammatory cytokines, such as IL-1, IL− 6 and TNF-α, both in vitro and in vivo. At the same time, the M2 macrophage (alternatively activated) polarization was promoted by TFDG. Animal experiments showed TFDG ameliorated joint destructions. For investigating the mechanisms, the targets of TFDG were predicted by bioinformatics tools. According to predictions, we hypothesized that TFDG could act with BCL-2 to weaken the interaction between BCL-2 and Beclin1. Beclin1 plays a central role in autophagy, and we found that the autophagy level of BMMs was recovered by TFDG. Besides, 3-MA, an autophagy inhibitor, could attenuate the therapeutic effect of TFDG. Conclusion TFDG protected against collagen-induced arthritis by attenuating the inflammation and promoting anti-inflammatory M2 macrophage polarization through controlling autophagy.

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Flavonoids: Food associations, therapeutic mechanisms, metabolism and nanoformulations

Cited by 29 publications

References 153 publications

Natural Flavonoids and Ferroptosis: Potential Therapeutic Opportunities for Human Diseases

Natural Flavonoids and Ferroptosis: Potential Therapeutic Opportunities for Human Diseases

Flavonoids Are Intra- and Inter-Kingdom Modulator Signals

Theaflavin-3,3’-Digallate Ameliorates Collagen-Induced Arthritis Through Regulation of Autophagy and Macrophage Polarization

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