Flavonoids exert multiple periodontic benefits including anti-inflammatory, periodontal ligament-supporting, and alveolar bone-preserving effects

Fernández-Rojas, Berenice; Gutiérrez-Venegas, Gloria

doi:10.1016/j.lfs.2018.08.029

Cited by 56 publications

(36 citation statements)

References 163 publications

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“…In recent years, an increasing number of studies have investigated natural compounds with gastroprotective effects, such as flavonoids, alkaloids, terpenes and terpenoids, saponins, phenolic acids, tannins, and fatty acids [ 19 , 20 , 21 , 22 , 23 ]. Of note, as one of the most abundant polyphenols in plants, flavonoids represent an important group of natural products that exhibit multiple pharmacological effects, such as antioxidative [ 24 ], anti-inflammatory [ 25 ], anticancer [ 26 ], antiviral [ 27 ], and anti-diabetic properties [ 28 , 29 , 30 , 31 ]. A large number of studies have demonstrated the protective effects of flavonoids on the intestinal epithelium [ 32 , 33 , 34 , 35 ], including maintaining intestinal barrier function, lipid and carbohydrate absorption, modulating enzyme activities, regulating the stomach of secretions, immune system regulation, and interaction with the pathogenic microorganism.…”

Section: Introductionmentioning

confidence: 99%

Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers

Zhang

Lian

et al. 2020

Molecules

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Peptic ulcer disease is a common gastrointestinal tract disorder that affects up to 20% of the population of the world. Treatment of peptic ulcer remains challenging due to the limited effectiveness and severe side effects of the currently available drugs. Hence, natural compounds, owing to their medicinal, ecological, and other safe properties, are becoming popular potential candidates in preventing and treating peptic ulcers. Flavonoids, the most abundant polyphenols in plants, exhibit gastroprotective effects against peptic ulcer both in vivo and in vitro. In this review, we summarized the anti-ulcer functions and mechanisms, and also the bioavailability, efficacy, and safety, of flavonoid monomers in the gastrointestinal tract. Flavonoids exerted cytoprotective and rehabilitative effects by not only strengthening defense factors, such as mucus and prostaglandins, but also protecting against potentially harmful factors via their antioxidative, anti-inflammatory, and antibacterial activities. Although controlled clinical studies are limited at present, flavonoids have shown a promising preventable and therapeutic potential in peptic ulcers.

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Section: Introductionmentioning

confidence: 99%

Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers

Zhang

Lian

et al. 2020

Molecules

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“…Flavonoids can be extracted from many edible plants and have various bioactivities such as anti‐inflammatory, anticarcinogenic, antioxidant and antiviral activity . Myricetin is a flavonoid component found in plants and has the antioxidant, anti‐inflammatory and antitumor properties.…”

Section: Discussionmentioning

confidence: 99%

Potential of myricetin to restore the immune balance in dextran sulfate sodium-induced acute murine ulcerative colitis

Liu

Song

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives Myricetin is a bioactive compound in many edible plants with anti‐inflammatory and anticarcinogenic activity. The current study aimed to determine the protective effects and mechanism of myricetin against ulcerative colitis (UC). Methods Myricetin was orally administered at doses of 40 and 80 mg/kg to C57BL/6 mice with UC induced using dextran sulfate sodium. The disease‐associated index and colon length were determined at the end of the experiment, the proportion of Treg, Th1 and Th17 was analysed by cytometry, and cytokines were detected using ELISA. Key findings Myricetin (80 mg/kg) ameliorated the severity of inflammation in acute UC and significantly improved the condition. Myricetin (80 mg/kg) elevated the levels of IL‐10 and transforming growth factor β. In addition, the proportion of regulatory T cells significantly increased in mice in the myricetin treatment group. Conclusions Taking together, these results suggest that myricetin exhibits significant protective effects against UC and it could be used as a potential treatment for UC.

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“…Periodontitis affects 30% of adults (4). cell biology and in vivo rodent model studies (5)(6)(7) have revealed a multiplicity of effects exerted by flavonoids on periodontal cells and tissues, including the regulation of the inflammatory response in periodontal components, and potential preserving effects on periodontal ligaments and alveolar bone tissues (8). Potentially beneficial effects of flavonoids have been reported in various periodontal cells, as well as alveolar bone-maintaining osteoblasts.…”

Section: Introductionmentioning

confidence: 99%

Polyphenols from grape pomace induce osteogenic differentiation in mesenchymal stem cells

Torre¹,

Iviglia²,

Cassinelli³

et al. 2020

Int J Mol Med

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Polyphenols are increasingly investigated for the treatment of periodontitis and research on their use in dental biomaterials is currently being conducted. Grape pomace extracts are a rich source of polyphenols. In the present study, the polyphenols of two different types of grape pomace were characterized and identified by high-performance liquid chromatography-diode array detector, and the effect of polyphenol-rich grape pomace extracts on mesenchymal stem cell (MSc) osteogenic differentiation was investigated. Solid-liquid extraction was used to recover polyphenols from red and white grape pomace. The two extracts have been characterized through the phenolic content and antioxidant power. Human MScs (hMScs) from the bone marrow were cultured both with and without given amounts (10 or 20 µg/ml) of the obtained pomace extracts. Their effects on cell differentiation were evaluated by reverse transcription-quantitative polymerase chain reaction, compared with relevant controls. Results showed that both pomace extracts, albeit different in phenolic composition and concentration, induced multiple effects on hMSc gene expression, such as a decreased receptor activator of nuclear factor κ-Β ligand/osteoprotegerin ratio and an enhanced expression of genes involved in osteoblast differentiation, thus suggesting a shift of hMScs towards osteoblast differentiation. The obtained results provided data in favor of the exploitation of polyphenol properties from grape pomace extracts as complementary active molecules for dental materials and devices for bone regeneration in periodontal defects.

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Flavonoids exert multiple periodontic benefits including anti-inflammatory, periodontal ligament-supporting, and alveolar bone-preserving effects

Cited by 56 publications

References 163 publications

Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers

Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers

Potential of myricetin to restore the immune balance in dextran sulfate sodium-induced acute murine ulcerative colitis

Polyphenols from grape pomace induce osteogenic differentiation in mesenchymal stem cells

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