Flavonoids casticin and chrysosplenol D from Artemisia annua L. inhibit inflammation in vitro and in vivo

Li, Yujie; Guo, Yan; Yang, Qing; Weng, Xiaogang; Liu, Yang; Wang, Yajie; Chen, Ying; Zhang, Dong; Li, Qi; Liu, Xu-Cen; Kan, Xiao‐Xi; Chen, Xi; Zhu, Xiongwei; Kmoníèková, Eva; Zídek, Z

doi:10.1016/j.taap.2015.04.005

Cited by 56 publications

(38 citation statements)

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“…Artemisia ordosica is a semi-shrubby plant of the genus Artemisia, mainly distributed in north and northwest sandy grassland of China, which not only contains rich nutrients -its flowering crude protein content reached 17.94%, crude fat content is 7.74%, but is also rich in polysaccharides, flavonoids, organic acids and other bio-active compositions, and the whole plant can be used as medicine. In recent years, studies about the effect of Artemisia plants on animals are more concentrated in wormwood and Artemisia annua L. (Li et al 2015;Wan et al 2016), but the impact of Artemisia ordosica is rarely reported.…”

Section: Introductionmentioning

confidence: 99%

DietaryArtemisia ordosicaextract alleviating immune stress in broilers exposed to lipopolysaccharide

Zhang

Shi

et al. 2017

Italian Journal of Animal Science

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This study was conducted to investigate the effect of Artemisia ordosica extract (AOE) on broilers challenged with lipopolysaccharide (LPS). 96 one-day-old Arbour Acres broilers were assigned in 2 Â 2 factorial design, including two dietary treatments (0 or 1000 mg/kg AOE) and two immunological challenge (saline or LPS). on d 14, 16, 18 and 20, broilers were injected intra-abdominally with LPS solution (the LPS was dissolved in sterile saline at a concentration of 100 lg/mL) at 500 lg/kg of base weight, or an equivalent amount of sterile saline. Blood samples were collected on d 21 and 28. During LPS-challenged periods (days 15-21), AOE alleviated the compromised average daily gain and average daily feed intake (p < .05) in broilers challenged with LPS. On day 21, the LPS challenge increased (p < .05) serum adrenocorticotropic hormone, corticosterone, interleukin-1, interleukin-2, interleukin-6, immunoglobulin G and immunoglobulin A, decreased (p < .05) the content of serum growth hormone and insulin-like growth factor-1. However, diet supplemented with AOE reduced the elevation of serum corticosterone (p ¼ .054), interleukin-2 (p < .05), immunoglobulin A (p < .05) and immunoglobulin G (p ¼ .079) caused by LPS on day 21. After a week's recovery, on d 28, AOE reduced the serum interleukin-6 content (p < .05). It may be that AOE exert its beneficial effect on broilers challenged with LPS by lessening the inflammatory cytokines and stress hormone, weakening the over activated immune system and finally, improving the growth performance.ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

DietaryArtemisia ordosicaextract alleviating immune stress in broilers exposed to lipopolysaccharide

Zhang

Shi

et al. 2017

Italian Journal of Animal Science

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“…A. annua also produces other anti-inflammatory phytochemicals, including flavonoids and monoterpenes. The flavonoids, casticin and chrysosplenol-D, reduced in vitro and in vivo inflammation [20], and the monoterpene, 1,8-cineol (eucalyptol) inhibited the production of six inflammatory cytokines in vitro [21]. A. annua also produces rosmarinic and chlorogenic acids, each of which has anti-inflammatory activity [22].…”

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confidence: 99%

Dried Leaf Artemisia Annua Improves Bioavailability of Artemisinin via Cytochrome P450 Inhibition and Enhances Artemisinin Efficacy Downstream

2020

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Artemisia annua L. and artemisinin, have been used for millennia to treat malaria. We used human liver microsomes (HLM) and rats to compare hepatic metabolism, tissue distribution, and inflammation attenuation by dried leaves of A. annua (DLA) and pure artemisinin. For HLM assays, extracts, teas, and phytochemicals from DLA were tested and IC50 values for CYP2B6 and CYP3A4 were measured. For tissue distribution studies, artemisinin or DLA was orally delivered to rats, tissues harvested at 1 h, and blood, urine and feces over 8 h; all were analyzed for artemisinin and deoxyartemisinin by GC-MS. For inflammation, rats received an intraperitoneal injection of water or lipopolysaccharide (LPS) and 70 mg/kg oral artemisinin as pure drug or DLA. Serum was collected over 8 h and analyzed by ELISA for TNF-α, IL-6, and IL-10. DLA-delivered artemisinin distributed to tissues in higher concentrations in vivo, but elimination remained mostly unchanged. This seemed to be due to inhibition of first-pass metabolism by DLA phytochemicals, as demonstrated by HLM assays of DLA extracts, teas and phytochemicals. DLA was more effective than artemisinin in males at attenuating proinflammatory cytokine production; the data were less conclusive in females. These results suggest that the oral consumption of artemisinin as DLA enhances the bioavailability and anti-inflammatory potency of artemisinin.

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“…Casticin, an active compound isolated from Vitex Fructusand , is well known for its pharmacological properties and has been utilized as an antihyperprolactinemia, antitumor, anti‐inflammatory, neuroprotetective, analgesic, and immunomodulatory agent (Rasul et al, ). Casticin suppresses LPS‐induced inflammatory response both in vivo and in vitro (Li et al, ). Recently, it is reported that casticin possesses protective effect on LPS‐induced acute lung injury (Wang et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Most studies related to casticin focused on the antitumor effect in different types of cancer (Rasul et al, 2014). Recently, several studies proved that casticin possessed anti-inflammatory effects both in vivo and in vitro (Li et al, 2015). In addition, casticin alleviated lipopolysaccharide (LPS)-induced lung injury by inhibiting inflammatory cytokines (Wang, Zeng, Zhang, Liu, & Wang, 2016).…”

mentioning

confidence: 99%

Casticin alleviates lipopolysaccharide‐induced inflammatory responses and expression of mucus and extracellular matrix in human airway epithelial cells through Nrf2/Keap1 and NF‐κB pathways

Wang

2018

Phytotherapy Research

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Asthma is one of the most common chronic inflammatory diseases of childhood, characterized by airway inflammation, mucus hypersecretion, and accumulation of extracellular matrix proteins. Casticin is an active compound that possesses broad biological activities including anti-inflammatory effect. However, the effect of casticin on asthma remains unknown. The aim of the present study was to evaluate the effect and mechanism of casticin on inflammatory responses and expression of mucus and extracellular matrix in human airway epithelial cells. The results showed that lipopolysaccharide induced the mRNA and protein levels of IL-6, IL-8, MUC5AC, collagen type I, and fibronectin in 16-HBE cells, whereas casticin treatment significantly inhibited the induction of lipopolysaccharide. Casticin induced Nrf2/Keap1 and inhibited nuclear factor κB pathways in 16-HBE cells. Knockdown of Nrf2 attenuated the effect of casticin on production of IL-6 and IL-8, expression of MUC5AC, collagen type I, and fibronectin in 16-HBE cells. In conclusion, the results indicated that casticin might be a novel therapeutic strategy for the treatment of asthma.

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Flavonoids casticin and chrysosplenol D from Artemisia annua L. inhibit inflammation in vitro and in vivo

Cited by 56 publications

References 45 publications

DietaryArtemisia ordosicaextract alleviating immune stress in broilers exposed to lipopolysaccharide

DietaryArtemisia ordosicaextract alleviating immune stress in broilers exposed to lipopolysaccharide

Dried Leaf Artemisia Annua Improves Bioavailability of Artemisinin via Cytochrome P450 Inhibition and Enhances Artemisinin Efficacy Downstream

Casticin alleviates lipopolysaccharide‐induced inflammatory responses and expression of mucus and extracellular matrix in human airway epithelial cells through Nrf2/Keap1 and NF‐κB pathways

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