Flavonoids as adjuvant in psoralen based photochemotherapy in the management of vitiligo/leucoderma

Shivasaraun, U.V.; Sureshkumar, Raman; Karthika, Chenmala; Puttappa, Nethravathi

doi:10.1016/j.mehy.2018.09.011

Cited by 16 publications

(16 citation statements)

References 34 publications

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“…59,60 The limited evidence on the side effects of flavonoids could thus be related to the relatively scarce concentration in commercial formulations and low dermal availability. Nonetheless, with the booming of green and natural ingredients, new beneficial activities associated with this class of biomolecules, [61][62][63][64][65][66][67] and advances in topical formulations, 68,69 we cannot exclude a rise in reported side effects as a consequence of increased consumer exposure.…”

Section: Discussionmentioning

confidence: 99%

Integrated Testing Strategy for the Safety of Botanical Ingredients: A Case Study with German Chamomile Constituents

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Wang

Ahn

et al. 2021

Applied In Vitro Toxicology

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Introduction: German chamomile is a botanical ingredient commonly used in cosmetics, thus determination of skin sensitization effects of German chamomile constituents is critical for the safety of consumers. Nonetheless, a systematic investigation of skin sensitization potential of chamomile constituents is lacking. Non-animal methods for skin sensitization hazard evaluation have been progressively accepted as attractive alternatives to conventional animal models, especially when used in an integrated fashion. Materials and Methods: In the present work, 30 constituents of German chamomile were investigated for skin sensitization using in silico, in chemico, and in vitro methods, including classification-quantitative structure-activity relationship (c-QSAR) models (ADMET predictor and CASE Ultra), an expert knowledge-based system (Derek Nexus), the Direct Peptide Reactivity Assay (DPRA), the high-throughput assay with dansylated cysteamine (HTS-DCYA), the KeratinoSens Ô assay, and the human Cell Line Activation Test (h-CLAT). Results and Discussion: Identical classification was found for 14 compounds upon comparison between computational and experimental methods. Seven compounds (umbelliferone, apigenin, kaempferol, isorhamnetin, nerol, a-terpinene, and carvone) were positive in both models, that is, in silico and experimental settings. Seven other compounds (caffeic acid, t-ferulic acid, cosemetin, hyperoside, a-terpineol, a-bisabolol, and chamazulene) were determined to be non-sensitizers instead. Conclusions: Among the compounds positive in experimental settings, umbelliferone and farnesene should be regarded as a potential concern because of their positive classification and significant concentration in German chamomile.

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Section: Discussionmentioning

confidence: 99%

Integrated Testing Strategy for the Safety of Botanical Ingredients: A Case Study with German Chamomile Constituents

Avonto

Wang

Ahn

et al. 2021

Applied In Vitro Toxicology

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“…Paradoxically, in some cases, the application of phenolic compounds has shown beneficial effects in the therapy of vitiligo [165], an autoimmune-determined disturbance in melanogenesis manifesting itself as white patches on the skin [166]. Such cases occur when (1) phenolics are used as whitening agents in order simulate merging of the white vitiligo spots and lead to total whitening (depigmentation therapy; synthetic or semisynthetic phenolics), or (2) antioxidants protect the melanocytes and keratinocytes [167] (mostly natural or semisynthetic phenolics). Oxidative stress is considered one of the main inducers of auto-reactive T-cells against the epidermal melanocytes and the destruction of the latter [166].…”

Section: Effects On Melanin Synthesismentioning

confidence: 99%

Dermal Drug Delivery of Phytochemicals with Phenolic Structure via Lipid-Based Nanotechnologies

et al. 2021

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Phenolic compounds are a large, heterogeneous group of secondary metabolites found in various plants and herbal substances. From the perspective of dermatology, the most important benefits for human health are their pharmacological effects on oxidation processes, inflammation, vascular pathology, immune response, precancerous and oncological lesions or formations, and microbial growth. Because the nature of phenolic compounds is designed to fit the phytochemical needs of plants and not the biopharmaceutical requirements for a specific route of delivery (dermal or other), their utilization in cutaneous formulations sets challenges to drug development. These are encountered often due to insufficient water solubility, high molecular weight and low permeation and/or high reactivity (inherent for the set of representatives) and subsequent chemical/photochemical instability and ionizability. The inclusion of phenolic phytochemicals in lipid-based nanocarriers (such as nanoemulsions, liposomes and solid lipid nanoparticles) is so far recognized as a strategic physico-chemical approach to improve their in situ stability and introduction to the skin barriers, with a view to enhance bioavailability and therapeutic potency. This current review is focused on recent advances and achievements in this area.

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“…Besides, luteolin, apparently blocks TNF and IL-1 to release IL-8 in melanocyte, indicating an antioxidant and anti-inflammatory effect of luteolin on early vitiligo [84]. Nowadays, it is consistently considered that the combined use of flavonoids with psoralen UVA or trimethylpsoralen would be a desired vehicle for vitiligo treatment [91].…”

Section: Flavonoids In Vitiligomentioning

confidence: 99%

Current evidence to support the therapeutic potential of flavonoids in oxidative stress-related dermatoses

Xian

Guo

et al. 2021

Redox Report

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Background: Skin, as a crucial external defense organ, is more vulnerable to oxidative stress (OS) insult, reactive oxygen species (ROS)-mediated OS in particular. OS results from a redox imbalance caused by various extrinsic stimuli and occurs once the oxidants production overwhelming the antioxidants capacity, through mediating in DNA damage, lipid peroxidation (LPO), protein oxidation and a serial of signaling pathways activation/inactivation, thereby offering favorable conditions for the occurrence and development of numerous diseases especially some dermatoses, e.g. psoriasis, vitiligo, skin photodamage, skin cancer, systemic sclerosis (SSc), chloasma, atopic dermatitis (AD), pemphigus, etc. Targeting OS molecular mechanism, a variety of anti-OS agents emerge, in which flavonoids, natural plant extracts, stand out. Objectives: To discuss the possible mechanisms of OS mediating in dermatoses and summarize the properties of flavonoids as well as their applications in OS-related skin disorders. Methods: Published papers on flavonoids and OS-related skin diseases were collected and reviewed via database searching on PubMed, MEDLINE and Embase, etc. Results: It has been confirmed that flavonoids, belonging to polyphenols, are a class of plant secondary metabolites widely distributed in various plants and possess diverse bioactivities especially their potent antioxidant capacity. Moreover, flavonoids benefit to suppress OS via eliminating free radicals and mediating the corresponding signals, further excellently working in the prevention and management of OS-related skin diseases. Conclusion: Flavonoids have the potential therapeutic effects on oxidative stress-related dermatoses. However, more studies on specific mechanism as well as the dosage of flavonoids are needed in future.

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Flavonoids as adjuvant in psoralen based photochemotherapy in the management of vitiligo/leucoderma

Cited by 16 publications

References 34 publications

Integrated Testing Strategy for the Safety of Botanical Ingredients: A Case Study with German Chamomile Constituents

Integrated Testing Strategy for the Safety of Botanical Ingredients: A Case Study with German Chamomile Constituents

Dermal Drug Delivery of Phytochemicals with Phenolic Structure via Lipid-Based Nanotechnologies

Current evidence to support the therapeutic potential of flavonoids in oxidative stress-related dermatoses

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