Flavonoids and tyrosine nitration: structure–activity relationship correlation with enthalpy of formation

Sadeghipour, Mitra; Terreux, Raphaël; Phipps, J.

doi:10.1016/j.tiv.2004.06.009

Cited by 57 publications

(36 citation statements)

References 67 publications

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“…The basic structure of the phenols and other structural factors play a fundamental role in the mechanism by which these compounds are able to scavenge free radicals (Sadeghipour et al, 2005). As underlined also by others (Lata et al, 2009;Lata, 2008), it is difficult to compare the content of apple phenolic among different studies, as many variations can be principally caused by different growth period, geographic location, storage type, genetic diversity and many other factors.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of antioxidant activity of Malus domestica fruit extract from Kashan area

Jelodarian¹,

Ebrahimabadi²,

Ahmad³

et al. 2015

Afr. J. Agric. Res.

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Objective: Antioxidants are considered as the main factors in the inhibition of unwanted oxidation reactions. Materials and Methods: In this research the antioxidant potential of the fresh fruits of 4 cultivars (A to D) of Malus domestica (M. domestica) cultivated in the Kashan, Qamsar area was evaluated. The antioxidant activity of the samples were evaluated using two complementary antioxidant assays: 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and β-carotene/linoleic acid tests and the results were compared with the synthetic standard antioxidant butylated hydroxytoluene (BHT). Results: Total phenolic contents of the samples are also estimated by Folin-Ciocalteu's phenol test. In both DPPH β-carotene/linoleic acid tests in the concentration of 2 mg/ml, only samples from cultivar A showed moderate antioxidant activity with 63.92±0.42 and 6.02±0.03 inhibition percentages, respectively and other samples were weakly active. Conclusion:The Folin-Ciocalteu's phenol test was also showed very little phenolic compounds for the fruits. In conclusion, weak antioxidant activity was estimated for the studied apple cultivars.

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Section: Discussionmentioning

confidence: 99%

Evaluation of antioxidant activity of Malus domestica fruit extract from Kashan area

Jelodarian¹,

Ebrahimabadi²,

Ahmad³

et al. 2015

Afr. J. Agric. Res.

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“…18,25 Luteolin and quercetin have been classified as excellent inhibitors of tyrosine nitration. 47 The catecholic B-ring, present in both referred flavonoids, plays an essential role in what concerns the inhibition process. This can be explained by the mechanism behind the reaction of catechol like compounds with peroxynitrite derivatives, which is likely to involve two electron transfer reactions with the formation of o-quinones.…”

Section: Discussionmentioning

confidence: 99%

“…This can be explained by the mechanism behind the reaction of catechol like compounds with peroxynitrite derivatives, which is likely to involve two electron transfer reactions with the formation of o-quinones. [47][48][49] Considering the structural similarity between the above-referred flavonoids and the 2-styrylchromones from group 1, it is very likely that these compounds can offer a biologically relevant protection against ONOO À -induced deleterious effects.…”

Section: Discussionmentioning

confidence: 99%

2-Styrylchromones: Novel strong scavengers of reactive oxygen and nitrogen species

Gomes

Fernandes

Silva

et al. 2007

Bioorganic & Medicinal Chemistry

126

173

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Abstract-2-Styrylchromones are a small group of naturally occurring chromones, vinylogues of flavones (2-phenylchromones). Natural and synthetic 2-styrylchromones have been tested in different biological systems, showing activities with potential therapeutic applications. In particular, the potential and hitherto understudied antioxidant behavior of these compounds has been raised as a matter of interest. Thus the present work consisted in the study of the in vitro scavenging activities for reactive oxygen species (ROS) and reactive nitrogen species (RNS) of various 2-styrylchromone derivatives and structurally similar flavonoids. Some of the studied 2-styrylchromones proved to be extremely efficient scavengers of the different ROS and RNS, showing, in some cases, IC 50 s under 1 lM. The hydroxylation pattern of 2-styrylchromones, especially in the B-ring but also in the A ring, modulates the activity of these compounds, the catecholic derivatives being the most effective scavengers. The styryl pattern also contributes to their observed outstanding antioxidant activity. In conclusion, the scavenging activities for ROS/RNS of 2-styrylchromone derivatives, here shown for the first time, provide novel and most promising compounds to be applied as antioxidants.

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“…However, Bozan et al (10) asserted that the higher antiradical activity of the extracts with lower C content may result from other flavonoid components of the extracts. Phenolic compounds scavenge free radicals by their aromatic hydroxyl groups, whose scavenging potential can be enhanced by electron donation from other constituents (29,30).…”

Section: Discussionmentioning

confidence: 99%

Protective roles of Cimin grape tissues on oxidative stress markers in the cellular system model

Uydu¹,

Ekinci²,

Atak³

et al. 2014

Turk J Med Sci

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Flavonoids and tyrosine nitration: structure–activity relationship correlation with enthalpy of formation

Cited by 57 publications

References 67 publications

Evaluation of antioxidant activity of Malus domestica fruit extract from Kashan area

Evaluation of antioxidant activity of Malus domestica fruit extract from Kashan area

2-Styrylchromones: Novel strong scavengers of reactive oxygen and nitrogen species

Protective roles of Cimin grape tissues on oxidative stress markers in the cellular system model

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