Flavonoids and stilbenoids as a promising arsenal for the management of chronic arsenic toxicity

Mishra, Awanish; Oliinyk, Petro; Lysiuk, Roman; Lenchyk, Larysa; Rathode, Suraj Singh S; Antonyak, Halyna; Darmohray, Roman; Dub, Natalia; Antoniv, Olha; Tsal, Oksana; Upyr, Taras

doi:10.1016/j.etap.2022.103970

Cited by 13 publications

(6 citation statements)

References 72 publications

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“…shows that native and indigenous plant-based active biomolecules appear to mitigate arsenic-induced toxicity with an acceptable safety profile. Various phytochemicals such as flavonoids and stilbenoids have antioxidant and chelation effects, which may facilitate the removal of arsenic from the body more effectively and safely as compared to conventional approaches [9].…”

Section: Discussionmentioning

confidence: 99%

Arsenic toxicity following Ayurvedic medication

Shinde

Bhattaram

Shinde

et al. 2022

Indian J Case Reports

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Alternative forms of medicine like Ayurveda have witnessed a rise in global popularity over the recent decades. Drugs used in Ayurveda, particularly those of mineral origin can lead to toxic effects due to heavy metal overdose. Here, we report the case of a 53-year-old woman who presented with glove-and-stocking paresthesia and scaly plaques following the institution of Ayurvedic drugs containing arsenic for dermatitis. She also had a loss of distal proprioception and a hyperesthetic response to pinprick. Her blood analysis showed elevated arsenic levels; 12 times the acceptable upper limit, with normal lead, cadmium, mercury, and chromium levels. The drug was immediately stopped and there was a gradual but incomplete resolution of the paresthesia and distal weakness over the next several months. The risk of heavy metal toxicity should be briefed to the patient before the start of mineral Ayurvedic drugs. Monitoring serum levels while on these medications might help identify toxicities early and can result in the commencement of therapy at an early stage.

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Section: Discussionmentioning

confidence: 99%

Arsenic toxicity following Ayurvedic medication

Shinde

Bhattaram

Shinde

et al. 2022

Indian J Case Reports

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“…This activity is related to free radical scavenging, chelation of transition metal ions, increase in GSH content and modulation of defensive gene expression via the nuclear erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway, which is an inherent defensive mechanism towards oxidative stress. Moreover, flavonoids, apart from their activity as free radical scavengers [58] and regulators of defensive gene expression, are also excellent chelators [59]. The free radical scavenging characteristics of flavonoids may be attributed to the amount and position of the free −OH groups in their molecular structure [60].…”

Section: Flavonoidsmentioning

confidence: 99%

Phytochemicals Involved in Mitigating Silent Toxicity Induced by Heavy Metals

Ceramella,

De Maio,

Basile

et al. 2024

Foods

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Heavy metals (HMs) are natural elements present in the Earth’s crust, characterised by a high atomic mass and a density more than five times higher than water. Despite their origin from natural sources, extensive usage and processing of raw materials and their presence as silent poisons in our daily products and diets have drastically altered their biochemical balance, making them a threat to the environment and human health. Particularly, the food chain polluted with toxic metals represents a crucial route of human exposure. Therefore, the impact of HMs on human health has become a matter of concern because of the severe chronic effects induced by their excessive levels in the human body. Chelation therapy is an approved valid treatment for HM poisoning; however, despite the efficacy demonstrated by chelating agents, various dramatic side effects may occur. Numerous data demonstrate that dietary components and phytoantioxidants play a significant role in preventing or reducing the damage induced by HMs. This review summarises the role of various phytochemicals, plant and herbal extracts or probiotics in promoting human health by mitigating the toxic effects of different HMs.

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“…7 However, the use of arsenic is limited by its toxicity to normal tissue and the inability to achieve deep tumor penetration. 8 Therefore, we hypothesized that the therapeutic effect of arsenic on liver cancer could be improved by optimizing the tumor distribution in vivo and enhancing tumor deep penetration.…”

Section: Introductionmentioning

confidence: 99%