Flavonoids and related compounds as inhibitors of arachidonic acid peroxidation

Baumann, J.; Bruchhausen, Franz von; Wurm, G.

doi:10.1016/0090-6980(80)90103-3

Cited by 249 publications

(104 citation statements)

References 25 publications

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“…Dry extracts of red wine contain phenolic compounds that have been shown in vitro to be strong reactive oxygen species scavengers (Bauman et al, 1980;Torel et al, 1986;Roback & Griglewski, 1988). Red wine-extracted¯avo-noids protect LDL against oxidation in vitro (De Walley et al, 1990; Ne Ágre-Salvayre & Salvayre, 1992; Frankel et al, 1993;Frankel et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Supplementation with wine phenolic compounds increases the antioxidant capacity of plasma and vitamin E of low-density lipoprotein without changing the lipoprotein Cu2+-oxidizability: Possible explanation by phenolic location

Carbonneau¹,

Léger²,

Monnier

et al. 1997

Eur J Clin Nutr

101

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Objectives: To evaluate the effect of the red wine phenolic compound (RWPC) dietary supplementation without alcohol interference on: (1) some of the biochemical characteristics of LDL, (2) the oxidative susceptibility of LDL and (3) the antioxidant capacity of total plasma (Pl-AOC). In order to account for discrepancies between the three series of data, the in vitro stability of the association of phenolic compounds and LDL was tested. Design: An intervention study with 20 volunteers. Each served as his own control. Cu 2 -oxidizability of LDL and Pl-AOC were tested on blood samples before and after dietary supplementation. Cu 2 -oxidizability of LDL was also tested by co-incubation in the presence of RWPC or phenolic acids with or without extensive dialysis. Setting: The Laboratory of Lipid Biochemistry and Biology, School of Medicine, and the Laboratory of Metabolic Diseases, Lapeyronie Hospital, University of Montpellier, France. Subjects: Healthy males, nonsmokers and moderate drinkers, submitted to a dietary regimen deprived of vitamin E and C for a period of 10 d before supplementation. They also abstained from alcohol, wine, fruit juices, coffee, tea and cola beverages during this period. Intervention: Six 0.33 g capsulesad (namely two capsules at each meal) of a preparation of red wine phenolic compounds in a dry powder form were given to the volunteers over a period of two weeks. Blood samples were drawn in fasting conditions at day 0 and day 14 of the supplementation period. Results: Supplementation led to: (1) in LDL, a signi®cant increase in vitamin E content (n 20, P 0.01) or vitamin Eatotal fatty acid bis-allylic carbon number ratio (n 20, P 0.006) without modi®cation in the other biochemical characteristics or Cu 2 -oxidizability; (2) in plasma, a signi®cant increase in the antioxidant capacity (n 11, P 0.01). In vitro studies showed that RWPC or sinapic, caffeic or ferulic acids incubated in the presence of LDL increased the protection of the lipoparticle against oxidation (caffeic b sinapic b ferulic). This effect, however, was totally lost after extensive dialysis. Conclusions: The enhancing effect of the RWPC supplementation on Pl-AOC may be due to a phenoliccompound action both in the aqueous phase of plasma and at the surface of lipoprotein particles. Surface location possibly explains the enhancing-sparing effect of supplementation on LDL vitamin E and the absence of effect on dialysed-LDL oxidizability.

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Section: Introductionmentioning

confidence: 99%

Supplementation with wine phenolic compounds increases the antioxidant capacity of plasma and vitamin E of low-density lipoprotein without changing the lipoprotein Cu2+-oxidizability: Possible explanation by phenolic location

Carbonneau¹,

Léger²,

Monnier

et al. 1997

Eur J Clin Nutr

101

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“…Flavonoids, phenolic acids like caffeic acid phenethyl ester (CAPE), and esters are the most biologically active compounds (Table 2) (Burdock, 1998;Daugsch et al, 2008;Baumann et al, 1980;Silva et al, 2007). These compounds exert multiple effects on bacteria, fungi and viruses and also present anti-inflammatory, antioxidant, immunomodulatory, wound healing, antiproliferative and antitumor activities (Machado et al, 2008;Pagliarone et al, 2009;Buyukberber et al, 2009;Jaganathan & Mandal, 2009;Medic-Saric et al, 2009;Pillai et al, 2010;Moreira et al, 2011;Lotfy, 2006).…”

Section: Anti-inflammatory and Immunomodulatory Response To Isolated mentioning

confidence: 99%

Mechanisms of action underlying the anti-inflammatory and immunomodulatory effects of propolis: a brief review

Araújo

Libério

Guerra

et al. 2012

Rev. bras. farmacogn.

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Many biological properties have been attributed to various types of propolis, including anti-inflammatory, antimicrobial, antioxidant, antitumor, wound healing, and immunomodulatory activities. This article reviewed studies published that investigated the anti-inflammatory activity of propolis of different origins and/ or its isolated components, focusing on the mechanisms of action underlying this activity and also addressing some aspects of immunomodulatory effects. The search was performed of the following databases: PubMed, Science Direct, HighWire Press, Scielo, Google Academics, Research Gate and ISI Web of Knowledgement. The anti-inflammatory activity was associated with propolis or compounds such as polyphenols (flavonoids, phenolic acids and their esters), terpenoids, steroids and amino acids. CAPE is the most studied compounds. The main mechanisms underlying the anti-inflammatory activity of propolis included the inhibition of cyclooxygenase and consequent inhibition of prostaglandin biosynthesis, free radical scavenging, inhibition of nitric oxide synthesis, reduction in the concentration of inflammatory cytokines and immunosuppressive activity. Propolis was found to exert an antiinflammatory activity in vivo and in vitro models of acute and chronic inflammation and others studies, indicating its promising potential as anti-inflammatory agent of natural origin and as a source of chemical compounds for the development of new drugs.

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“…Las linfoquinas (IL1, IL8, y TNF) y el LTB4 ejercen los efectos quimiotácticos más intensos. Finalmente, los radicales libres derivados del oxígeno producidos en el medio extracelular principalmente por los fagocitos (células polimorfonucleares y macrófagos) contribuyen de varias maneras a las lesiones inflamatorias; lo cual induce histolisis (fibroblastos, células endoteliales, eritrocitos), que aumentan la permeabilidad de las paredes vasculares y perpetúan el proceso inflamatorio 1,2 .…”

Section: Discussionunclassified

Uso de flavonoides (Hesperidina) en el tratamiento de venas varicosas vesicales sangrantes

Loarca

2003

Actas Urológicas Españolas

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RESUMEN USO DE FLAVONOIDES (HESPERIDINA) EN EL TRATAMIENTO DE VENAS VARICOSASVESICALES SANGRANTES OBJETIVO: Informar del uso de los Flavonoides (Hesperidina) en el tratamiento de varices vesicales, y su eficacia.PACIENTES: Se informa de 4 casos que acudieron por hematuria, y que en la cistoscopia se observó varices vesicales, sangrantes en 2 casos; en ellos se utilizó Hesperidina 150 Mg. bid o tid por 30 días.RESULTADOS: Fueron buenos, en los 2 casos que sangraban desapareció la hematuria y en los 4 casos en la cistoscopia de control las varices habían desaparecido.CONCLUSIONES: El tratamiento antivaricoso o anti-hemorroidal puede ser útil en el tratamiento de varices vesicales. Se debe de dar como mínimo por 30 días PALABRAS CLAVE: Varices vesicales. Hesperidina. Antivaricoso. ABSTRACT TREATMENT OF BLADDER VARICOSE VEINS WITH FLAVONOIDS (HESPERIDINA)OBJECTIVE: To inform of the use of the Flavonoids in the treatment of bladder varicose veins, and their effectiveness.PATIENT: It is informed of 4 cases that went for haematuria, and that in the cistoscopy one observes bladder varicose veins, bleeding in 2 cases, in them you uses Hesperidina 150 mg bid or tid for 30 days.RESULTS: They were good, the 2 cases that bled the haematuria disappeared and in the 4 cases in the control cistoscopy the varicose veins had disappeared.CONCLUSIONS: The treatment antivaricose or antihemorrhoidal can be useful in the treatment of bladder varicose veins. It should be given as minimum by 30 days. CASOS CLÍNICOSCaso nº 1: Paciente de 38 años femenina, que acudió por presentar hematuria de 5 días. Antecedentes de hematuria en 2 ocasiones que cedieron sin tratamiento. Al examen físico se observó venas varicosas en las extremidades inferiores, las cuales se había infiltrado en 2 ocasiones,

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Flavonoids and related compounds as inhibitors of arachidonic acid peroxidation

Cited by 249 publications

References 25 publications

Supplementation with wine phenolic compounds increases the antioxidant capacity of plasma and vitamin E of low-density lipoprotein without changing the lipoprotein Cu2+-oxidizability: Possible explanation by phenolic location

Supplementation with wine phenolic compounds increases the antioxidant capacity of plasma and vitamin E of low-density lipoprotein without changing the lipoprotein Cu2+-oxidizability: Possible explanation by phenolic location

Mechanisms of action underlying the anti-inflammatory and immunomodulatory effects of propolis: a brief review

Uso de flavonoides (Hesperidina) en el tratamiento de venas varicosas vesicales sangrantes

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